A5062611895- Cancer survivorship and care
- Orthopedic Surgery and Rehabilitation
- Peripheral Nerve Disorders
- Tendon Structure and Treatment
- Spine and Intervertebral Disc Pathology
- Shoulder Injury and Treatment
- Nerve Injury and Rehabilitation
- Sports injuries and prevention
- Palliative Care and End-of-Life Issues
- Foot and Ankle Surgery
- Voice and Speech Disorders
- Health Systems, Economic Evaluations, Quality of Life
- Musculoskeletal pain and rehabilitation
- Knee injuries and reconstruction techniques
- Tracheal and airway disorders
- Mesenchymal stem cell research
- Anatomy and Medical Technology
- Cerebrovascular and Carotid Artery Diseases
- Family Support in Illness
- Orthopaedic implants and arthroplasty
- Meta-analysis and systematic reviews
- Gallbladder and Bile Duct Disorders
- Intracranial Aneurysms: Treatment and Complications
- Peripheral Artery Disease Management
- Facial Nerve Paralysis Treatment and Research
Andrzej Frycz Modrzewski Krakow University
2019-2025
Jagiellonian University
2014-2023
Scanmed (Poland)
2019-2023
AGH University of Krakow
2020
St. Raphael's Hospital
2020
Jesuit University Ignatianum
1970-2018
Trinity College Dublin
2015-2018
Seattle Foundation
2016-2017
Seattle University
2016-2017
Kazimierz Wielki University in Bydgoszcz
2017
ObjectiveThe objective of this study was to establish thresholds for clinical importance (TCIs) the five functioning and nine symptom scales European Organisation Research Treatment Cancer Quality Life Questionnaire Core 30 (EORTC QLQ-C30).Study Design SettingIn diagnostic study, cancer patients with mixed diagnoses treatments completed EORTC QLQ-C30 anchored questions in each domain terms their importance. The anchor questions, concerned limitations daily life, need help/care, worries...
Evidence-Based Anatomy (EBA) is the concept of applying evidence-based principles and research methods to anatomical sciences. While narrative reviews are common in sciences, true systematic (SR) meta-analysis (MA) only beginning grow popularity. In order enhance quality future EBA studies, ensure clinical reliability their results, a uniform methodology needed. this paper, we present step-by-step methodological guide for performing SRs MAs studies. We address EBA-specific challenges each...
Critical appraisal of anatomical studies is essential before the evidence from them undergoes meta-epidemiological synthesis. However, no instrument for appraising with inherent applicability to different study designs available. We aim develop a generic yet comprehensive tool assessing quality using formal consensus method. The steering committee formulated an initial conceptual design and generated items preliminary on basis literature review expert opinion. A Delphi procedure was then...
Tissue regeneration using human adipose derived mesenchymal stem cells (hASCs) has significant potential as a novel treatment for many degenerative bone and joint diseases. Previous studies have established that age negatively affects the proliferation status osteogenic chondrogenic differentiation of cells. The aim this study was to assess age‐related maintenance physiological function hASCs in vitro. were isolated from patients four different groups: (1) >20 years ( n = 7), (2) >50...
The number of cancer survivors is growing steadily and increasingly, clinical trials are being designed to include long-term follow-up assess not only survival, but also late effects health-related quality life (HRQOL). Therefore it essential develop patient-reported outcome measures (PROMs) that capture the full range issues relevant disease-free survivors. objectives this project are: 1) a European Organisation for Research Treatment Cancer (EORTC) questionnaire captures physical, mental...
The European Organisation for Research and Treatment of Cancer (EORTC) Group has developed a new multidimensional instrument measuring cancer-related fatigue to be used in conjunction with the quality life core questionnaire (EORTC QLQ-C30). module EORTC QLQ-FA13 assesses physical, cognitive, emotional aspects fatigue.The methodology follows guidelines phase IV validation modules. This paper focuses on results psychometric factorial structure module. For cross-validation confirmatory factor...
The rise of evidence-based anatomy has emphasized the need for original anatomical studies with high clarity, transparency, and comprehensiveness in reporting. Currently, inconsistencies quality reporting such have placed limits on accurate reliability impact assessment. Our aim was to develop a checklist items that should be addressed by authors studies. study steering committee formulated preliminary conceptual design began generate basis literature review expert opinion. This led...
Human adipose tissue is a great source of autologous mesenchymal stem cells (hASCs), which are recognized for their vast therapeutic applications. Their ability to self-renew and differentiate into several lineages makes them promising tool cell-based therapies in different types degenerative diseases. Thus it crucial evaluate age-related changes hASCs, as the elderly group that will benefit most from considerable potential. In this study we investigated effect donor age on growth kinetics,...
The 5th EORTC Quality of Life in Cancer Clinical Trials Conference presented the current state quality life and other patient-reported outcomes (PROs) research from perspectives researchers, regulators, industry representatives, patients patient advocates health care professionals. A major theme was assessment burden cancer treatments, this discussed terms regulatory challenges using PRO assessments clinical trials, patients' experiences innovative methods standardisation research, across...
The EORTC QLQ-C30 is one of the most widely used quality life questionnaires in cancer research. Availability thresholds for clinical importance individual questionnaire domains could help to increase its interpretability. aim our study was identify four scales: Physical Functioning (PF), Emotional (EF), Pain (PA) and Fatigue (FA).We recruited adult patients from Austria, Netherlands, Poland UK. No restrictions were placed on diagnosis or type stage treatment. Patients completed three anchor...
The Achilles tendon ( AT ) consists of fibers originating from the soleus muscle SOL ), which lies deep, and medial GM lateral GL heads gastrocnemius muscle, lie superficial. As descend toward insertion , individual subtendons twist around each other. aim this study was to investigate twisted structure its subtendons. Specimens with preserved calcaneal bone a fragment triceps surae were obtained 53 fresh‐frozen, male cadavers (n=106 lower limbs). angle torsion 's measured using specially...
Due to its pleiotropic effects, the commonly used drug metformin has gained renewed interest among medical researchers. While is mainly for treatment of diabetes, recent studies suggest that it may have further application in anticancer and antiaging therapies. In this study, we investigated proliferative potential, accumulation oxidative stress factors, osteogenic adipogenic differentiation potential mouse adipose‐derived stem cells (MuASCs) isolated from mice treated with 8 weeks....
The Non-Recurrent Laryngeal Nerve (NRLN) is a rare embryologically-derived variant of the Recurrent (RLN). presence an NRLN significantly increases risk iatrogenic injury and operative complications. Our aim was to provide comprehensive meta-analysis overall prevalence NRLN, its origin, association with aberrant subclavian artery.Through March 2016, database search performed PubMed, CNKI, ScienceDirect, EMBASE, BIOSIS, SciELO, Web Science. references in included articles were also...
Abstract Human adipose tissue is a great source of adult mesenchymal stem cells ( MSC s) which are recognized from their ability to self‐renew and differentiation into multiple lineages. s have promised vast therapeutic potential in treatment many diseases including injury immune disorders. However, regenerative profoundly depends on patients’ age. Age‐related deterioration associated with cellular senescence mainly caused by increased DNA methylation status, accumulation oxidative stress...
Abstract The major mechanisms of gallstone formation include biliary cholesterol hypersecretion, supersaturation and crystallization, mucus gel bile stasis. Gallbladder hypomotility seems to be a key event that triggers the precipitation microcrystals from supersaturated lithogenic bile. Telocytes, new type interstitial cells, have been recently identified in many organs, including gallbladder. Considering telocyte functions, it is presumed these cells might involved signalling processes....