A5003663181- Cancer survivorship and care
- Cognitive Abilities and Testing
- Childhood Cancer Survivors' Quality of Life
- Cancer-related cognitive impairment studies
- Genetics and Neurodevelopmental Disorders
- Hypothalamic control of reproductive hormones
- Genetic Associations and Epidemiology
- Birth, Development, and Health
- Sexual Differentiation and Disorders
- Menopause: Health Impacts and Treatments
- Nutrition and Health in Aging
- Reading and Literacy Development
- Assisted Reproductive Technology and Twin Pregnancy
- Infant Development and Preterm Care
- Genetics and Physical Performance
- Stress Responses and Cortisol
- Child and Adolescent Psychosocial and Emotional Development
- Hormonal and reproductive studies
- Global Peace and Security Dynamics
- Cerebral Palsy and Movement Disorders
- Multiple and Secondary Primary Cancers
- Neuroendocrine regulation and behavior
- Bladder and Urothelial Cancer Treatments
- CAR-T cell therapy research
- Circadian rhythm and melatonin
Oncode Institute
2016-2024
The Netherlands Cancer Institute
2012-2024
Southern California Institute of Architecture
2016
Engineering Arts (United States)
2016
Vrije Universiteit Amsterdam
2005-2013
Sydney Hospital
2001
The University of Sydney
2001
ObjectiveThe objective of this study was to establish thresholds for clinical importance (TCIs) the five functioning and nine symptom scales European Organisation Research Treatment Cancer Quality Life Questionnaire Core 30 (EORTC QLQ-C30).Study Design SettingIn diagnostic study, cancer patients with mixed diagnoses treatments completed EORTC QLQ-C30 anchored questions in each domain terms their importance. The anchor questions, concerned limitations daily life, need help/care, worries...
The number of cancer survivors is growing steadily and increasingly, clinical trials are being designed to include long-term follow-up assess not only survival, but also late effects health-related quality life (HRQOL). Therefore it essential develop patient-reported outcome measures (PROMs) that capture the full range issues relevant disease-free survivors. objectives this project are: 1) a European Organisation for Research Treatment Cancer (EORTC) questionnaire captures physical, mental...
Abstract Puberty represents the phase of sexual maturity, signaling change from childhood into adulthood. During and adolescence, prominent changes take place in brain. Recently, variation frontal, temporal, parietal areas was found to be under varying genetic control between 5 19 years age. However, at onset puberty, extent which brain structures is influenced by factors (heritability) not known. Moreover, whether a direct link human pubertal development structure exists has been studied....
Patient-reported physical function (PF) is a key endpoint in cancer clinical trials. Using complex statistical methods, common metrics have been developed to compare scores from different patient-reported outcome (PRO) measures, but such methods do not account for possible differences questionnaire content. Therefore, the aim of our study was content comparison frequently used PRO measures PF patients.
We evaluated the effect of Internet-based cognitive behavioral therapy (iCBT), with or without therapist support, on perceived impact hot flushes and night sweats (HF/NS) overall levels menopausal symptoms (primary outcomes), sleep quality, HF/NS frequency, sexual functioning, psychological distress, health-related quality life in breast cancer survivors treatment-induced symptoms.We randomly assigned 254 to a therapist-guided self-managed iCBT group waiting list control group. The 6-week...
The longitudinal stability of IQ is well-documented as its increasing heritability with age. In a twin study, we addressed the question to what extent and differ for full scale (FSIQ), verbal (VIQ), performance (PIQ) in childhood (age 9–11 years), early adolescence 12–14 years). Genetic environmental influences correlations over time were evaluated an extended design, including Dutch twins their siblings. Intelligence was measured by Wechsler Scale children — Third version (WISC III)....
In an extended twin study we estimated the heritability of fasting HbA1c and blood glucose levels. Blood was assessed in different settings (at home clinic). We tested whether genetic factors influencing levels overlapped with those same were expressed across settings. Fasting measured at during two visits to clinic 77 healthy families same-sex twins siblings, aged 20 45 years. first visit. A 4-variate structural equation model used that each trait correlations among traits. Heritability...
It is assumed that attention problems (AP) are related to impaired executive functioning.We investigated the association between AP and inhibitory control tested what extent was due genetic factors shared with IQ.Data were available from 3 independent samples of 9-, 12-, 18-year-old twins their siblings (1,209 participants).AP assessed checklists completed by multiple informants.Inhibitory measured Stroop Color Word Task (Stroop, 1935), IQ Wechsler Intelligence Scale for Children (Wechsler...
From childhood into adolescence, the child's brain undergoes considerable changes in both structure and function. Twin studies are of great value to explore what extent genetic environmental factors explain individual differences development cognition. In The Netherlands, we initiated a longitudinal study which twins, their siblings parents assessed at three year intervals. participants were recruited from Netherlands Register (NTR) baseline consisted 112 families, with 9-year-old twins an...
Brain volume of boys is larger than that girls by approximately 10%. Prenatal exposure to testosterone has been suggested in the masculinization brain. For example, litter-bearing mammals intrauterine position increases prenatal through adjacent male fetuses, resulting brain morphology.The influence presence a co-twin on human was studied 9-year old twins.Magnetic resonance imaging scans, current testosterone, and estradiol levels were acquired from four groups dizygotic (DZ) twins: same-sex...
Abstract Objective: Previous studies demonstrated that a cognitive behavioral therapy (CBT) program delivered in group sessions is effective alleviating treatment-induced menopausal symptoms women with breast cancer, but also in-person CBT inconvenient for some and can result low levels of compliance. A promising, alternative approach to use the Internet make this form more accessible feasible patients. The objective study was evaluate feasibility generate preliminary data on efficacy...
Information on the correlation of normative reproductive hormone levels with physical development (Tanner stages) during puberty and influences genes environment variation in these hormones Tanner stages is limited.One hundred twelve healthy 9-year-old twin pairs (n = 224) took part a longitudinal study, which 89 participated again at age 12 years 178).Morning urinary LH, FSH, estradiol, salivary testosterone levels, determined by competitive immunoassays, were measured. through...
Cancer and its treatment can have substantial impact on patients' emotional functioning. Several patient-reported outcome measures (PROMs) assessing functioning are available, but differences in content limit the comparability of results. To better understand conceptual (dis)similarities, we conducted a comparison commonly used PROMs.We included items, scales, item banks from EORTC CAT Core, QLQ-C30, FACT-G, Hospital anxiety depression scale (HADS), SF-36, PRO-CTCAE, PROMIS (item for...