A5003870479- Glioma Diagnosis and Treatment
- Cancer-related cognitive impairment studies
- Brain Metastases and Treatment
- Cancer survivorship and care
- Childhood Cancer Survivors' Quality of Life
- Advanced Neuroimaging Techniques and Applications
- CNS Lymphoma Diagnosis and Treatment
- Optimism, Hope, and Well-being
- Meningioma and schwannoma management
- Functional Brain Connectivity Studies
- Scoliosis diagnosis and treatment
- Cognitive Functions and Memory
- Nanoplatforms for cancer theranostics
- Endoplasmic Reticulum Stress and Disease
- Health and Well-being Studies
- Ubiquitin and proteasome pathways
- Stroke Rehabilitation and Recovery
- Musculoskeletal pain and rehabilitation
- Dementia and Cognitive Impairment Research
- Lung Cancer Research Studies
- Traumatic Brain Injury Research
- Brain Tumor Detection and Classification
Medisch Centrum Haaglanden
2012-2021
Leiden University Medical Center
2015-2017
Bispebjerg Hospital
2017
Erasmus MC Cancer Institute
2015
Amsterdam UMC Location VUmc
2015
Maastricht University
2009
Abstract Background Stereotactic radiotherapy (SRT) is expected to have a less detrimental effect on neurocognitive functioning and health-related quality of life (HRQoL) than whole-brain radiotherapy. To evaluate the impact brain metastases SRT HRQoL, we performed prospective study. Methods Neurocognitive HRQoL 97 patients with were measured before 1, 3, 6 months after SRT. Seven cognitive domains assessed. was assessed European Organisation for Research Treatment Cancer (EORTC) QLQ-C30...
Abstract Patients with a diffuse glioma may experience cognitive decline or improvement upon resective surgery. To examine the impact of location, alteration after surgery was quantified and related to voxel‐based resection probability maps. A total 59 consecutive patients (range 18–67 years age) who had between 2006 2011 for supratentorial nonenhancing (grade I–III, WHO 2007) were included in this observational cohort study. Standardized neuropsychological examination MRI obtained before...
Recently, it has been shown that at group level, patients with limited brain metastases treated stereotactic radiotherapy (SRT) maintain their pre-treatment levels of neurocognitive functioning (NCF) and health-related quality life (HRQoL). The aim this study was to evaluate NCF HRQoL changes over time the individual patient level. (seven domains assessed a standardized test battery) (eight predetermined scales EORTC QLQ-C30 BN20 questionnaires) were measured prior SRT 3 and/or 6 months...
Abstract Background To analyze the effect of treatment on neurocognitive functioning and association neurocognition with radiological abnormalities in primary central nervous system lymphoma (PCNSL). Methods One hundred ninety-nine patients from a phase III trial (HOVON 105/ALLG NHL 24), randomized to standard chemotherapy or without rituximab, followed ≤60 years old by 30-Gy whole-brain radiotherapy (WBRT), were asked participate neuropsychological evaluation before during treatment, up 2...
The European Organisation for Research and Treatment of Cancer (EORTC) Quality Life Group is developing computerized adaptive testing (CAT) versions each scale the EORTC Questionnaire (EORTC QLQ-C30). This study aims to develop an item bank QLQ-C30 cognitive functioning scale, which can be used CAT.The complete developmental approach comprised four phases: (I) conceptualization literature search, (II) operationalization, (III) pretesting, (IV) field-testing. paper describes phases I-III.I) A...
Glioma patients may experience behavioral and personality changes (BPC), negatively impacting their lives that of relatives. However, there is no clear definition BPC for adult glioma patients, here we aimed to determine which characteristics are relevant include in this definition.Possible were identified the literature presented (former) caregivers an online survey launched via International Brain Tumour Alliance. Participants had rate relevance each characteristic BPC, three with most...
Abstract BACKGROUND Glioma patients may experience behavioral and personality changes (BPC), which have a negative impact on the lives of both brain tumor their relatives. The extent BPC is currently unknown, it unclear if available assessment tools cover all aspects that are relevant for glioma patients. This study aimed to determine characteristics METHODS Possible were identified in literature based expert opinion. Next, these 49 items presented caregivers/former caregivers an online...
BACKGROUND: Although stereotactic radiotherapy (SRT) for brain metastases is expected to have a less detrimental effect on cognition and health-related quality of life (HRQoL) than whole-brain (WBRT), the precise largely unknown. METHODS: Cognition HRQoL were measured prior SRT, 3 6 months follow-up. Four cognitive domains seven preselected scales EORTC-QLQC30 BN20 analysed. Survival analysis was performed total volume Karnofsky Performance Status (KPS) (both categorized) overall survival...
INTRODUCTION: Stereotactic radiotherapy (SRT) is the current treatment of choice in patients with one to three brain metastases. Although survival rates are assumed be similar, SRT expected have a less detrimental effect on cognition and health-related quality life (HRQoL) than whole-brain (WBRT). OBJECTIVE: To prospectively study impact HRQoL cognitive functioning metastatic disease. METHODS: A total 97 were included prior treatment. Cognitive measured at baseline, 3 6 months follow-up....
Abstract BACKGROUND The goal of treatment primary central nervous system lymphoma patients is to improve survival, without compromising neurocognitive functioning. aim this study was analyze the effect Rituximab and low-dose whole brain radiotherapy (WBRT) on cognition. METHODS 199 from a phase III trial (HOVON 105/ ALLG NHL 24), randomized standard chemotherapy (and 30Gy WBRT for < 61 years-old only) with or Rituximab, were asked participate in short neuropsychological evaluation (NPE)...
INTRODUCTION: Cognition is at risk in patients with brain tumors. Cognitive alterations, improvement or decline, may result from tumor surgery, as well other factors such direct effects, radiotherapy, chemotherapy, anti-epileptic drugs, and steroids. In this study, cognitive alterations after surgery are quantified correlated location using resection probability maps, which a new approach. METHODS: Adult were included, who had (1) tumor, (2) resective between 2006 2011, (3) baseline...
INTRODUCTION: Cognition is often affected in patients with brain tumors. Apart from language function, direct tumor effects on discrete cognitive functions have barely been studied. In this study, we quantify baseline functioning seven domains and identify locations involved these using localization maps (TLMs), which a new approach. METHODS: Adult glioma treated at the VU University Medical Center between 2006-2011 available preoperative neuropsychological assessment were included. was...
INTRODUCTION: Cognition is at risk in patients with brain tumors. Cognitive alterations, improvement or decline, may result from tumor surgery, as well other factors such direct effects, radiotherapy, chemotherapy, anti-epileptic drugs, and steroids. In this study, cognitive alterations after surgery are quantified correlated location using resection probability maps, which a new approach. METHODS: Adult were included, who had (1) tumor, (2) resective between 2006 2011, (3) baseline...