A5063772828- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- EEG and Brain-Computer Interfaces
- Functional Brain Connectivity Studies
- Neural dynamics and brain function
- Memory and Neural Mechanisms
- Sleep and Wakefulness Research
- Neuroscience and Neural Engineering
- Neonatal and fetal brain pathology
- Genomics and Rare Diseases
- Neurological disorders and treatments
- Genetics and Neurodevelopmental Disorders
- Cerebrovascular and Carotid Artery Diseases
- Acute Ischemic Stroke Management
- Neurological and metabolic disorders
- Alzheimer's disease research and treatments
- Advanced Neuroimaging Techniques and Applications
- Diet and metabolism studies
- Anesthesia and Neurotoxicity Research
- Intracranial Aneurysms: Treatment and Complications
- Glycogen Storage Diseases and Myoclonus
- Healthcare Systems and Practices
- Memory Processes and Influences
- Computational Drug Discovery Methods
Centre de recherche cerveau et cognition
2015-2024
Centre National de la Recherche Scientifique
2014-2024
Centre Hospitalier Universitaire de Toulouse
2013-2024
Université Toulouse III - Paul Sabatier
2018-2024
Université de Toulouse
2000-2023
Hôpital Purpan
2016-2023
Hôpital Paule de Viguier
2014-2022
Inserm
2007-2021
Institut de Mathématiques de Toulouse
2019
Universidade de São Paulo
2015-2018
Aggravation of idiopathic generalized epilepsy (IGE) syndromes by inappropriate antiepileptic drugs (AEDs) is increasingly recognized as a serious and common problem. Precipitation status epilepticus (SE) medication has rarely been reported. We retrospectively studied all adult patients with IGE taking at least one potentially aggravating AED, who developed video-EEG documented SE over 8 years, whose long-term outcome was favourable after adjustment medication. identified 14 (seven male...
Loss of consciousness (LOC) is a dramatic clinical manifestation temporal lobe seizures. Its underlying mechanism could involve altered coordinated neuronal activity between the brain regions that support conscious information processing. The access hypothesis assumes existence global workspace in which becomes available via synchronized within modules, often widely distributed throughout brain. Re-entry loops and, particular, thalamo-cortical communication would be crucial to functionally...
<h3>Objective:</h3> To identify the clinical determinants of occurrence postictal generalized EEG suppression (PGES) after convulsive seizures (GCS). <h3>Methods:</h3> We reviewed video-EEG recordings 417 patients included in REPO<sub>2</sub>MSE study, a multicenter prospective cohort study with drug-resistant focal epilepsy. According to ictal semiology, we classified GCS into 3 types: tonic-clonic bilateral and symmetric tonic arm extension (type 1), clonic without or flexion 2),...
In patients with pharmaco-resistant focal epilepsies investigated intracranial electroencephalography (iEEG), direct electrical stimulations of a cortical region induce cortico-cortical evoked potentials (CCEP) in distant cerebral cortex, which properties can be used to infer large scale brain connectivity. 2013, we proposed new probabilistic functional tractography methodology study human We have now been revisiting this method the F-TRACT project (f-tract.eu) by developing multicenter CCEP...
Despite its well-known effectiveness, the cost-effectiveness of epilepsy surgery has never been demonstrated in France. We compared between resective and medical therapy a controlled cohort adult patients with partial intractable epilepsy.A prospective surgically remediable medically was followed over 5 years 15 French centers. Effectiveness defined as 1 year without seizure, based on International League Against Epilepsy (ILAE) classification. Clinical outcomes direct costs were surgical...
Summary Purpose: Generalized convulsive status epilepticus (GCSE) needs immediate management. Despite guidelines, adherence to management protocols is often poor, this contributing poor outcome. We aimed evaluate the usefulness of a protocol in GCSE. Methods: This prospective population‐based study consecutive adults with GCSE Haute‐Garonne district, France. Demographics and treatment procedures were documented. Factors associated seizure termination refractoriness analyzed using logistic...
Abstract Epilepsy presurgical investigation may include focal intracortical single-pulse electrical stimulations with depth electrodes, which induce cortico-cortical evoked potentials at distant sites because of white matter connectivity. Cortico-cortical provide a unique window on functional brain networks they contain sufficient information to infer dynamical properties large-scale connectivity, such as preferred directionality and propagation latencies. Here, we developed biologically...
<h3>Objective</h3> To analyze the factors that determine occurrence or severity of postictal hypoxemia in immediate aftermath a generalized convulsive seizure (GCS). <h3>Methods</h3> We reviewed video-EEG recordings 1,006 patients with drug-resistant focal epilepsy included REPO<sub>2</sub>MSE study to identify those ≥1 GCS and pulse oximetry (SpO<sub>2</sub>) measurement. Factors determining recovery SpO<sub>2</sub> ≥ 90% were investigated using Cox proportional hazards models. Association...
Background and Purpose Asymptomatic cerebral emboli may be detected in patients with carotid stenosis by transcranial Doppler ultrasonography of the middle artery (MCA). The aim this study was to determine angiographic correlates such embolic signals. Methods signals from 48 MCAs 26 that either symptomatic (n=20) or asymptomatic (n=6) were recorded for 40 minutes. grade ulcerated nonulcerated appearance plaque assessed using criteria North American Symptomatic Carotid Endarterectomy Trial....
Background and Purpose —The clinical application of Doppler detection circulating cerebral emboli will depend on a reliable automated system embolic signal detection; such is not currently available. Previous studies have shown that frequency filtering increases the ratio to background intensity incorporation an approach into offline markedly improved performance. In this study, we evaluated online version system. single-center compared its performance with human expert data from 2...
Abstract Understanding the neuronal basis of epileptic activity is a major challenge in neurology. Cellular integration into larger scale networks all more challenging. In local field potential, interictal discharges can be associated with fast ripples (200–600 Hz), which are promising marker epileptogenic zone. Yet, how populations zone and healthy tissue affected by remain unclear. Here, we used novel ‘hybrid’ macro–micro depth electrode nine drug-resistant patients, combining classic...
The mechanisms underlying epileptogenicity in tuberous sclerosis complex (TSC) are poorly understood. We analysed neuronal spiking activity (84 neurons), fast ripples (FRs), local field potentials and intracranial electroencephalogram during interictal epileptiform discharges (IEDs) the tuber perituber of a patient using novel hybrid electrodes equipped with tetrodes. IEDs were recorded perituber. FRs only microelectrodes. A larger proportion neurons (57%) than (17%) had firing-rates...
The aim of this work was to test the hypothesis that patients with temporal lobe epilepsy (TLE) subjective initial memory complaints (not confirmed by an objective standard assessment) and various phenotypes also show very long-term deficit accelerated forgetting. We tested TLE 2 surprise tests after 3 weeks: Free Cued Selective Reminding Test (FCSRT) Epireal, a new specifically designed capture more ecologic aspects autobiographical memory.Forty-seven (12 hippocampal sclerosis, 12 amygdala...