A5002277805- Epilepsy research and treatment
- Pharmacological Effects and Toxicity Studies
- Neuroscience and Neuropharmacology Research
- Genetics and Neurodevelopmental Disorders
- Advanced Radiotherapy Techniques
- Neonatal and fetal brain pathology
- Memory and Neural Mechanisms
- Genomics and Rare Diseases
- Autoimmune Neurological Disorders and Treatments
- Glycogen Storage Diseases and Myoclonus
- Metabolism and Genetic Disorders
- EEG and Brain-Computer Interfaces
- Psychoanalysis and Psychopathology Research
- Neurological disorders and treatments
- Photonic and Optical Devices
- Optical and Acousto-Optic Technologies
- Psychology and Mental Health
- Ion channel regulation and function
- Child and Animal Learning Development
- Genetic Associations and Epidemiology
- Spatial Cognition and Navigation
- Health, Medicine and Society
- Genetic Mapping and Diversity in Plants and Animals
- Sexual function and dysfunction studies
- Cannabis and Cannabinoid Research
Centre National de la Recherche Scientifique
2008-2025
Inserm
2008-2025
Sorbonne Université
2012-2025
Assistance Publique – Hôpitaux de Paris
2008-2025
Pitié-Salpêtrière Hospital
2008-2025
Institut du Cerveau
2000-2025
Université Sorbonne Nouvelle
2020-2024
Institut de Psychiatrie et Neurosciences de Paris
2020-2023
Université Paris 1 Panthéon-Sorbonne
2023
Hôpital Charles-Foix
2020-2021
Amorphic mutations in the recombination activating genes RAG1 and RAG2 have been reported to cause T–B– SCID, whereas hypomorphic led expansion of a few autoimmune T cell clones responsible for Omenn syndrome phenotype. We report here novel clinical immunological phenotype associated with recessive 4 patients from different families. The consists oligoclonal TCRγδ cells combined TCRαβ lymphopenia. severe, disseminated CMV infection blood manifestations. Repertoire studies suggest that...
<h3>Objective:</h3> To identify the clinical determinants of occurrence postictal generalized EEG suppression (PGES) after convulsive seizures (GCS). <h3>Methods:</h3> We reviewed video-EEG recordings 417 patients included in REPO<sub>2</sub>MSE study, a multicenter prospective cohort study with drug-resistant focal epilepsy. According to ictal semiology, we classified GCS into 3 types: tonic-clonic bilateral and symmetric tonic arm extension (type 1), clonic without or flexion 2),...
<b>Objective: </b> To clarify the clinical and neurophysiologic spectrum of myoclonus–dystonia patients with mutations <i>SGCE</i> gene. <b>Methods: We prospectively studied 41 consecutive from 22 families documented The had a standardized interview, neurologic examination, detailed including surface polymyography, long-loop C-reflex studies, EEG jerk-locked back averaging. <b>Results: noted homogeneous electrophysiologic pattern myoclonus subcortical origin short jerks (mean 95 msec, range...
Background and purpose Medial temporal lobe epilepsy with unilateral hippocampal sclerosis ( MTLE ‐ HS ) is the most frequent form of surgical epilepsy. In this study, it was aimed to determine whether different types aura represent a cardinal characteristic feature might provide diagnostic complement help identify patients who will be seizure‐free after surgery. Methods All auras associations reported by 400 referred for surgery were retrospectively collected their statistical correlation...
<h3>Objective</h3> To analyze the factors that determine occurrence or severity of postictal hypoxemia in immediate aftermath a generalized convulsive seizure (GCS). <h3>Methods</h3> We reviewed video-EEG recordings 1,006 patients with drug-resistant focal epilepsy included REPO<sub>2</sub>MSE study to identify those ≥1 GCS and pulse oximetry (SpO<sub>2</sub>) measurement. Factors determining recovery SpO<sub>2</sub> ≥ 90% were investigated using Cox proportional hazards models. Association...
Highlights•The COVID-19 pandemic accelerated the shift to remote systems.•25% of respondents use personal systems without any protection data.•Epileptologists positively evaluated their experience with system.•The in Italy and France was no longer lower than China.•The long-term effects widespread need further evaluation.AbstractPurposeThe purpose study describe epileptologists' opinion on increased implemented during across clinics, education, scientific meetings activities.MethodsBetween...
This study assesses the role of human medial temporal lobe (MTL) structures in coordination spatial information across perspective change and, particular, visual taking--namely capacity to know what another individual is seeing on scene. Fourteen patients with unilateral resection and 21 control subjects performed two tasks, called 'object location memory' 'viewpoint recognition', respectively. In object memory task, had memorize position a target environment from an initial viewpoint. They...
Abstract Objective We aimed to delineate the phenotypic spectrum and long‐term outcome of individuals with KCNB1 encephalopathy. Methods collected genetic, clinical, electroencephalographic, imaging data pathogenic variants recruited through an international collaboration, support family association “KCNB1 France.” Patients were classified as having developmental epileptic encephalopathy (DEE) or (DE). In addition, we reviewed published cases provided in patients older than 12 years from our...
Abstract Background and purpose The specific effects of antiseizure medications (ASMs) on cognition are a rich field study, with many ongoing questions. aim this study was to evaluate these in homogeneous group patients epilepsy guide clinicians choose the most appropriate medications. Methods We retrospectively identified 287 refractory medial temporal lobe associated hippocampal sclerosis. Scores measuring general (global, verbal performance IQ), working memory, episodic executive...
A clinical risk score for sudden unexpected death in epilepsy (SUDEP) patients with drug-resistant focal could help improve prevention.A case-control study was conducted including (i) definite or probable SUDEP cases collected by the French National Sentinel Mortality Epilepsy Network and (ii) control from national research database of monitoring units. Patients were eligible. Multiple logistic regressions performed. After sensitivity analysis internal validation, a simplified developed...
Abstract Temporal pole epilepsy (TPE) is a poorly known and difficult to individualize subtype of temporal lobe epilepsy. Consequently, in drug‐resistant TPE, there still debate on the need for large surgical removal mesial structures or limited resection pole. We reviewed all patients who underwent presurgical evaluation over 17‐year period, report here 19 with proven selective respect structures. Most (15) TPE exhibited seizures resembling mesiotemporal seizures, whereas others nocturnal...
To assess the efficacy and tolerability of zonisamide in a study allowing flexible dosing more diverse less refractory population than assessed randomized controlled trials.This 19-week, non-comparative adjunctive included 281 adults who had at least four partial-onset seizures within 8 weeks on one or two antiepileptic drugs. Alterations to doses were allowed after titration, except during fixed-dose periods (weeks 10-13 16-19).At end second period (median dose 300 mg/day), median reduction...
Type 2 diabetes is a heterogeneous disorder of glucose metabolism characterized by insulin resistance, β-cell dysfunction, and increased production the liver. Given high degree genetic heterogeneity, multiple genes with small to moderate effects may influence susceptibility diabetes. To circumvent this limitation, we searched for quantitative trait loci (QTLs) that explain variation in type single extended family, as these individuals are likely share polymorphisms. We collected genotypic...