A5014817946- Immune Cell Function and Interaction
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- CAR-T cell therapy research
- Renal Transplantation Outcomes and Treatments
- Herpesvirus Infections and Treatments
- Cell Adhesion Molecules Research
- Inflammasome and immune disorders
- Mycobacterium research and diagnosis
- Blood groups and transfusion
- Galectins and Cancer Biology
- Malaria Research and Control
- Systemic Lupus Erythematosus Research
- Reproductive System and Pregnancy
- Peptidase Inhibition and Analysis
- Pancreatic and Hepatic Oncology Research
- Immune Response and Inflammation
- Neurological Complications and Syndromes
- Hematopoietic Stem Cell Transplantation
- Complement system in diseases
- Diabetes and associated disorders
- Platelet Disorders and Treatments
- Pneumocystis jirovecii pneumonia detection and treatment
Université de Bordeaux
2014-2025
Centre National de la Recherche Scientifique
2015-2025
Immunology from Concept and Experiments to Translation
2015-2025
Inserm
2017-2025
La Ligue Contre le Cancer
2024-2025
Bordeaux Population Health
2020-2023
Fédération de recherche en imagerie multi-modalité
2020
Biofuel Research Team
2020
Centre National pour la Recherche Scientifique et Technique (CNRST)
2001-2011
Hôpital Cardiologique du Haut-Lévêque
2004
By triggering immunogenic cell death, some anticancer compounds, including anthracyclines and oxaliplatin, elicit tumor-specific, interferon-γ–producing CD8+ αβ T lymphocytes (Tc1 CTLs) that are pivotal for an optimal therapeutic outcome. Here, we demonstrate chemotherapy induces a rapid prominent invasion of interleukin (IL)-17–producing γδ (Vγ4+ Vγ6+) (γδ T17 cells) precedes the accumulation Tc1 CTLs within tumor bed. In receptor δ−/− or Vγ4/6−/− mice, efficacy was compromised, no IL-17...
γδ T lymphocytes represent ∼1% of human peripheral blood mononuclear cells and even more in most tissues vertebrates. Although they have important anticancer functions, current single-cell RNA sequencing (scRNA-seq) studies do not identify because their transcriptomes at the level are unknown. Here we show that high-resolution clustering large scRNA-seq datasets a combination gene signatures allow specific detection identification cell receptor (TCR)Vδ1 TCRVδ2 subsets from complex mixtures....
Long-lasting expansion of Vdelta2(neg) gammadelta T cells is a hallmark cytomegalovirus (CMV) infection in kidney transplant recipients. The ligands these and their role remain elusive. To better understand immune function, we generated cell clones from several transplanted patients. Numerous patient Vdelta1(+), Vdelta3(+), Vdelta5(+) expressing diverse Vgamma chains, but not control Vgamma9Vdelta2(+) clones, displayed strong reactivity against CMV-infected cells, as shown by production...
Amorphic mutations in the recombination activating genes RAG1 and RAG2 have been reported to cause T–B– SCID, whereas hypomorphic led expansion of a few autoimmune T cell clones responsible for Omenn syndrome phenotype. We report here novel clinical immunological phenotype associated with recessive 4 patients from different families. The consists oligoclonal TCRγδ cells combined TCRαβ lymphopenia. severe, disseminated CMV infection blood manifestations. Repertoire studies suggest that...
Immunosenescence, defined as the age-associated dysregulation and dysfunction of immune system, is characterized by impaired protective immunity decreased efficacy vaccines. An increasing number immunological, clinical epidemiological studies suggest that persistent Cytomegalovirus (CMV) infection associated with accelerated aging system several age-related diseases. However, current evidence on whether how human CMV (HCMV) implicated in immunosenescence diseases remains incomplete many...
Significance Human γδ T lymphocytes have innate-like and adaptive-like functions can circulate in blood or reside tissues. They are activated by specific antigens recognized their T-cell receptor recognize infected transformed cells, suggesting that cellular stress is involved antigen expression. However, molecular characterization of stress-induced remains elusive, hampering our understanding the role cells cancer infections. In present study we identify annexin A2 as such known a...
Acute myeloid leukemia (AML) remains a clinical challenge due to frequent chemotherapy resistance and deadly relapses. We are exploring the immunotherapeutic potential of peripheral blood Vδ1+ T cells, which associate with improved long-term survival stem-cell transplant recipients but have not yet been applied as adoptive cell therapy. Using our clinical-grade protocol for expansion differentiation "Delta One T" (DOT) we found DOT cells be highly cytotoxic against AML primary samples lines,...
γδ T cells undergo massive expansion in the peripheral blood of renal transplant recipients who are infected with cytomegalovirus (CMV). In a 3-year prospective study, relationship between evolution CMV infection and kinetics cell amplification was followed for 10 months after transplantation. Patients late (⩾45 days) had significantly longer (P<.0001) higher (P<.0003) pp65 antigenemia more-symptomatic disease than did patients early expansion. Analysis data each patient showed that is...
The soluble form of CD40 (sCD40), which co-exists with the membrane-anchored (mCD40), is a natural antagonist mCD40/CD154 interaction. However, mechanism leading to production sCD40 has never been investigated. Here, we show that engagement mCD40 on surface B lymphocytes by anti-CD40 antibody led enhanced release associated decreased amounts mCD40. This was not affected vesicular traffic inhibitors but completely blocked broad-spectrum synthetic metalloproteinase (MP) inhibitor (GM6001) or...
Cytomegalovirus (CMV) is a leading infectious cause of morbidity in immune-compromised patients. γδ T cells have been involved the response to CMV but their role protection has not firmly established and dependency on other lymphocytes addressed. Using C57BL/6 αβ and/or cell-deficient mice, we here show that are as competent protect mice from CMV-induced death. cell-mediated control viral load prevented organ damage. cell recovery by bone marrow transplant or adoptive transfer experiments...
Abstract TIGIT is an immune checkpoint inhibitor expressed by effector CD4+ and CD8+ T cells, NK regulatory cells (Tregs). Inhibition of TIGIT-ligand binding using antagonistic anti-TIGIT mAbs has shown in vitro potential to restore T-cell function therapeutic efficacy murine tumor models when combined with anti–PD(L)-1 antibody. In the current work, we demonstrate broader expression than previously reported healthy donors patients cancer on γδ particularly CMV-seropositive donors, from...