A5015555302- Malaria Research and Control
- Immune Cell Function and Interaction
- Mosquito-borne diseases and control
- T-cell and B-cell Immunology
- Complement system in diseases
- HIV Research and Treatment
- Invertebrate Immune Response Mechanisms
- Immune Response and Inflammation
- Ancient and Medieval Archaeology Studies
- Byzantine Studies and History
- Historical and Archaeological Studies
- Computational Drug Discovery Methods
- Hemoglobinopathies and Related Disorders
- Vector-borne infectious diseases
- Immunotherapy and Immune Responses
- Diabetes and associated disorders
- Iron Metabolism and Disorders
- Drug Transport and Resistance Mechanisms
- Cell death mechanisms and regulation
- vaccines and immunoinformatics approaches
- Heat shock proteins research
- Second Language Learning and Teaching
- Linguistics and language evolution
- Archaeology and Historical Studies
- interferon and immune responses
University of Roehampton
2000-2018
Centre National de la Recherche Scientifique
2000-2017
Université de Bordeaux
2007-2017
Institut Pasteur
1998-2016
Immunology from Concept and Experiments to Translation
2007-2015
Biotherapy of Genetic Diseases, Inflammatory Disorders and Cancers
2012
Centre National pour la Recherche Scientifique et Technique (CNRST)
2009-2011
University of Nottingham
2010
Copenhagen University Hospital
2002
University of Copenhagen
2002
The presence in Plasmodium falciparum of a mitogenic factor for the major human blood gammadelta T-cell subset has been known years. These T cells bearing receptor Vgamma9 and Vdelta2 variable regions also respond to Mycobacterium tuberculosis, through recognition several phosphorylated nonpeptidic antigens. In this study, we undertook better characterization malarial stimulus show that polygonal activation Vgamma9/Vdelta2 by P. schizonts is exclusively attributable two compounds. finding...
A Plasmodium falciparum schizont Iysate has been previously described as being a powerful inducer of proliferation for human peripheral T lymphocytes. In this report we study the phenotype cycling cells from unexposed donors and examine how P. compares with conventional cell mitogen phytohemagglutinin (PHA), known superantigen staphylococcal enterotoxin B (SEB), classical antigen pure protein derivative (PPD). We show that lymphoprollferative activity interaction MHC class II molecule is...
BackgroundRespiratory distress (RD), a symptom of underlying metabolic acidosis, has been identified as major risk factor for mortality in children with severe malaria Africa, yet the molecular mediators involved pathogenesis RD have not
In this article, it is argued that Bede's famous account of the origin and early development people kings Kent in Historia ecclesiastica (I.15) does not report historical events, but reflects eighth‐century concepts migration‐period kingship with mythical links to Jutes Scandinavia. Bracteate evidence shows veneration Woden existed by sixth century. Support for a contemporary belief Scandinavian Kentish found locally produced bracteates, which imitate styles, where several recovered from...
Abstract Background Severe malarial anaemia (SMA) is a major life-threatening complication of paediatric malaria. Protracted production pro-inflammatory cytokines promoting erythrophagocytosis and depressing erythropoiesis thought to play an important role in SMA, which characterized by high TNF/IL-10 ratio. Whether this imbalance results from intrinsic incapacity SMA patients produce IL-10 or unresponsiveness infection unknown. Monocytes T cells are recognized as the main sources TNF vivo ,...
gamma delta T cells have variously been implicated in the protection against, and pathogenesis of, malaria, but few studies examined T-cell response to malaria African children, who suffer large majority of malaria-associated morbidity mortality. This is unfortunate, since available data suggest that simple extrapolation conclusions drawn from nonimmune adults ex vivo vitro not always possible. Here we show both frequencies absolute numbers are transiently increased following treatment...
TCR γδ+ cells constitute <5% of all circulating T in healthy, adult Caucasians, and Vδ1+ a minority these cells. In contrast to αβ+ cells, their repertoire is selected extrathymically by environmental antigens. Although increased frequencies are found several diseases, function remains obscure. Here we show that the frequency peripheral blood γδ healthy West Africans about twice mainly due 5-fold increase which consequently dominant subset. No age dependency Vδ1 was identified African donors...
Abstract Background Real-time PCR is becoming a common tool for detecting and quantifying expression profiling of selected genes. Cytokines mRNA quantification widely used in immunological research to dissect the early steps immune responses or pathophysiological pathways. It also growing be clinical relevancy immuno-monitoring evaluation disease status patients. The techniques currently "absolute quantification" cytokine are based on DNA standard curve do not take into account critical...
ABSTRACT Malaria induces potent activation and expansion of the Vγ9Vδ2 subpopulation γδT cells, which inhibit Plasmodium falciparum blood cycle through soluble cytotoxic mediators, abrogating merozoite invasion capacity. Intraerythrocytic stages efficiently trigger T-cell degranulation poorly understood mechanisms. P. blood-stage extracts are known to contain phosphoantigens able stimulate T but how these presented by intact infected red cells (iRBCs) remains elusive. Here we show that,...
During Plasmodium falciparum infections, erythrocyte-stage parasites inhibit dendritic cell maturation and function, compromising effective antimalarial adaptive immunity. Human Vγ9Vδ2 T cells can act in vitro as antigen-presenting (APCs) induce αβ T-cell activation. However, the relevance of this activity vivo has remained elusive. Because are activated during early immune response against P. infection, we investigated whether they could contribute to instruction responses toward malaria...
Abstract Pf72/Hsp70-1, a heat-shock protein of m.w. 72 kDa from Plasmodium falciparum is one the Ag interest to be included in polyvalent vaccine against malaria. It major immunogens present fraction purified blood stage parasites that elicited protection experimental infection Saimiri monkeys with stages P. falciparum. at all and its B cell epitopes also detected on surface infected hepatocyte. Moreover, Pf72 appears well conserved among different isolates We have examined immune response...
gammadelta T cells recognize stress-induced autoantigens and contribute to immunity against infections cancer. Our previous study revealed that Vdelta2-negative ((neg)) lymphocytes isolated from transplant recipients infected by cytomegalovirus (CMV) killed both CMV-infected HT29 colon cancer in vitro. To investigate the antitumor effects of Vdelta2(neg) clones vivo, we generated hypodermal tumors immunodeficient mice. Concomitant injections Vdelta2(neg)clones, contrast Vdelta2(+) cells,...
Summary Available evidence suggests that Plasmodium falciparum malaria causes activation and reallocation of T cells, these in vivo primed cells re-emerge into the periphery following drug therapy. Here we have examined cytokine production capacity susceptibility to programmed cell death peripheral during after period antimalarial treatment. A high proportion CD3+ had an activated phenotype at shortly time admission (day 0) initiation This peaked around day 2, this time-point from patients...
Epidemiological data point to an increased risk of HIV-1 mother-to-child transmission in pregnant women with malaria, by unknown mechanisms. We show here that surface binding a recombinant Plasmodium falciparum adhesin chondroitin sulphate A proteoglycans increases replication the human placental cell line BeWo, probably P. adhesin-induced long-terminal repeat-driven TNF-alpha stimulation. This suggests malaria could increase utero.
The physiopathology of experimental cerebral malaria (CM), an acute neurological complication Plasmodium berghei ANKA (PbA) infection, involves interferon‐ γ (IFN‐ ) and tumour necrosis factor‐ α (TNF‐ ), two cytokines that are known to modulate major histocompatibility complex (MHC) molecule expression. aim this study was evaluate whether the genetic susceptibility CM is related constitutive or IFN‐ ‐induced expression MHC molecules on brain microvessels. To end, microvascular endothelial...
Employability has become a global buzz-word: instructors in higher education are increasingly being called upon to produce highly employable students who will turn contribute the financial capital of country’s economy. For vocational subjects and degrees for which clear links industry may be envisaged (such as IT, Business, Technology Science) challenge is surmountable. However, it remains non-vocational subjects, especially degree programmes Arts Humanities, prove their merit this...