A5107501234- Cancer Cells and Metastasis
- Immune Cell Function and Interaction
- Cancer, Hypoxia, and Metabolism
- T-cell and B-cell Immunology
- Helicobacter pylori-related gastroenterology studies
- RNA Interference and Gene Delivery
- Cytomegalovirus and herpesvirus research
- Mesenchymal stem cell research
- RNA modifications and cancer
- Autophagy in Disease and Therapy
- Fibroblast Growth Factor Research
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- 3D Printing in Biomedical Research
- PI3K/AKT/mTOR signaling in cancer
- Cell death mechanisms and regulation
- Cancer Research and Treatments
- Advanced biosensing and bioanalysis techniques
- Shoulder Injury and Treatment
- Kruppel-like factors research
- Gallbladder and Bile Duct Disorders
- Mitochondrial Function and Pathology
- DNA and Nucleic Acid Chemistry
- Polyamine Metabolism and Applications
- Phagocytosis and Immune Regulation
Université de Bordeaux
2014-2024
Transgene (France)
2018
Bordeaux Population Health
2018
Inserm
2003-2018
Université Paris-Est Créteil
2016
Hôpitaux Universitaires Paris-Ouest
2016
Département Santé Animale
2016
Laboratory for the Bioengineering of Tissues
2012
Laboratoire Chrono-Environnement
2012
Centre Hospitalier Universitaire de Besançon
2012
Abstract Bioprinting has emerged as a novel technological approach with the potential to address unsolved questions in field of tissue engineering. We have recently shown that Laser Assisted (LAB), due its unprecedented cell printing resolution and precision, is an attractive tool for situ bone substitute. Here, we show LAB can be used mesenchymal stromal cells, associated collagen nano-hydroxyapatite, order favor regeneration, calvaria defect model mice. Also, by testing different...
Purpose: Gastric carcinomas are heterogeneous, and the current therapy remains essentially based on surgery with conventional chemotherapy radiotherapy. This study aimed to characterize biomarkers allowing detection of cancer stem cells (CSC) in human gastric carcinoma different histologic types.Experimental Design: The primary tumors from 37 patients intestinal- or diffuse-type noncardia were studied, patient-derived tumor xenograft (PDX) models immunodeficient mice developed. expressions...
Cytomegalovirus (CMV) is a leading infectious cause of morbidity in immune-compromised patients. γδ T cells have been involved the response to CMV but their role protection has not firmly established and dependency on other lymphocytes addressed. Using C57BL/6 αβ and/or cell-deficient mice, we here show that are as competent protect mice from CMV-induced death. cell-mediated control viral load prevented organ damage. cell recovery by bone marrow transplant or adoptive transfer experiments...
Internal tandem duplication in Fms-like tyrosine kinase 3 (FLT3-ITD) is the most frequent mutation observed acute myeloid leukemia (AML) and correlates with poor prognosis. FLT3 inhibitors are promising for targeted therapy. Here, we investigated mechanisms dampening response to inhibitor quizartinib, which specific hematopoietic niche. Using AML primary samples cell lines, demonstrate that convergent signals from microenvironment drive FLT3-ITD resistance quizartinib through expression...
G-quadruplex ligands exert their antiproliferative effects through telomere-dependent and telomere-independent mechanisms, but the inter-relationships among autophagy, cell growth arrest death induced by these remain largely unexplored. Here, we demonstrate that ligand 20A causes of cancer cells in culture a HeLa xenografted mouse model. This response is associated with induction senescence apoptosis. Transcriptomic analysis treated reveals significant functional enrichment biological...
Abstract Glutamoptosis is the induction of apoptotic cell death as a consequence aberrant activation glutaminolysis and mTORC1 signaling during nutritional imbalance in proliferating cells. The role bioenergetic sensor AMPK glutamoptosis not defined yet. Here, we show that reactivation blocks both glutamine-dependent vitro vivo. We also glutamine used for asparagine synthesis GABA shunt to produce ATP inhibit AMPK, independently glutaminolysis. Overall, our results indicate metabolism...
Abstract Gastric cancer’s (GC) bad prognosis is usually associated with metastatic spread. Invasive cancer stem cells (CSC) are considered to be the seed of GC metastasis and not all CSCs able initiate metastasis. Targeting these aggressive metastasis-initiating CSC (MIC) thus vital. Leukaemia inhibitory factor (LIF) hereby used target Hippo pathway oncogenic members, found induced in features. LIF-treated cell lines, patient-derived xenograft (PDX) and/or tumourspheres underwent...
Hydrogels that are non-toxic, easy to use, cytocompatible, injectable and degradable valuable biomaterials for tissue engineering repair.However, few compounds currently fulfi l these requirements.In this study, we describe the biological properties of a new type thermosensitive hydrogel based on low-molecular weight glycosyl-nucleosyl-fl uorinated (GNF) compound.This gel forms within 25 min by self-assembly monomers as temperature decreases.It degrades slowly in vitro vivo.It induces...
Significance Although a role for β-adrenergic receptor (ADRB) in cancer progression was suggested long time ago, our serendipitous observation of the propranolol efficacy treating infantile hemangioma (IH) has driven attention exploring antitumor properties β-blockers. We identified Aquaporine-1 (AQP1) as player response and histological marker IH vascular structures including telocytes, which are dendritic cells that form distinctive peripheral layer IH. conclude sensitivity to may rely, at...
Cytolethal distending toxins (CDTs) are common among pathogenic bacteria of the human and animal microbiota. CDTs exert cytopathic effets, via their active CdtB subunit. No clear description those effects has been reported at cellular level in target organs vivo. In present study, xenograft mouse models colon liver cell lines were set up to study subunit Helicobacter hepaticus. Conditional transgenic established, validated vitro then engrafted into immunodeficient mice. After successful...
The cellular receptor Notch1 is a central regulator of T‐cell development, and as consequence, pathway appears upregulated in > 65% the cases acute lymphoblastic leukemia (T‐ALL). However, strategies targeting signaling render only modest results clinic due to treatment resistance severe side effects. While many investigations reported different aspects tumor cell growth progression controlled by Notch1, less known regarding modifications metabolism induced upregulation T‐ALL. Previously,...
Due to frequent mutations in certain cancers, FGFR3 gene is considered as an oncogene. However, some normal tissues, can limit cell growth and promote differentiation. Thus, action appears paradoxical.FGFR3 expression was forced pancreatic lines. The receptor exerted dual effects: it suppressed tumor epithelial-like cells had oncogenic properties mesenchymal-like cells. Distinct exclusive pathways were activated, STATs MAP Kinases Both splice variants similar effects used the same...
Abstract Background Cancer stem cells (CSCs) are at the origin of tumour initiation and progression in gastric adenocarcinoma (GC). However, markers metastasis-initiating remain unidentified GC. In this study, we characterized CD44 variants expressed GC evaluated tumorigenic metastatic properties CD44v3+ their clinical significance patients. Methods Using cell lines patient-derived xenografts, CD44+ molecular signature tumorigenic, chemoresistance, invasive properties, expression...
Abstract The basic understanding of the biological effects eukaryotic translation initiation factors (EIFs) remains incomplete, notably for their roles independent protein translation. Different EIFs exhibit nuclear localization and DNA-related functions have been proposed, but novel beyond lacks integrative analyses between genomic proteomic levels. Here, noncanonical function EIF3F was studied in human lung adenocarcinoma by combining methods that revealed both protein–protein protein–DNA...
MicroRNAs regulate eukaryotic gene expression upon pairing onto target mRNAs. This targeting is influenced by the complementarity between microRNA "seed" sequence at its 5′ end and seed-matching sequences in mRNA. Here, we assess efficiency specificity of 8-mer locked nucleic acid (LNA)-modified oligonucleotides raised against seeds miR-372 miR-373, two embryonic stem cell-specific microRNAs prominently expressed human gastric adenocarcinoma AGS cell line. Provided that perfect over all...
// Kelly Airiau 1, 2 , Valérie Prouzet-Mauléon 1 Benoit Rousseau 3 Arnaud Pigneux Marie Jeanneteau Manon Giraudon Kaoutar Allou Pierre Dubus 4 Francis Belloc 2, * François-Xavier Mahon Laboratoire d'Hématopoïèse Leucémique et Cibles Thérapeutiques, INSERM 1035, Université Bordeaux, France CHU Hôpital Haut-Lévêque, d'Hématologie, Pessac, Animalerie A2, Bordeaux Segalen, EA 2406 Histologie Pathologie, These authors have contributed equally to this work Correspondence to: Mahon, e-mail:...
Trypanosoma brucei gambiense, transmitted by the tsetse fly, is main causative agent of Human African trypanosomosis in West Africa and poses a significant health risk to 70 million people. Disease progression varies depending on host immunity, but usually begins with haemo-lymphatic phase, followed parasite invasion central nervous system. In current study, tropism T. b. gambiense 1135, causing low level chronic 'silent' infection, was monitored murine model using bioluminescence imaging...