A5004010838- Cancer, Hypoxia, and Metabolism
- Mitochondrial Function and Pathology
- Epigenetics and DNA Methylation
- Ubiquitin and proteasome pathways
- RNA modifications and cancer
- Multiple Myeloma Research and Treatments
- Chemical Reactions and Isotopes
- Cancer, Stress, Anesthesia, and Immune Response
- RNA Research and Splicing
- Protein Degradation and Inhibitors
- Pancreatic function and diabetes
- Peroxisome Proliferator-Activated Receptors
- Galectins and Cancer Biology
- Bone and Dental Protein Studies
- Hip and Femur Fractures
- Cardiac, Anesthesia and Surgical Outcomes
- RNA and protein synthesis mechanisms
- Peptidase Inhibition and Analysis
- Metabolomics and Mass Spectrometry Studies
- Radiation Therapy and Dosimetry
- HER2/EGFR in Cancer Research
- COVID-19 and healthcare impacts
- Chronic Lymphocytic Leukemia Research
- Microbial metabolism and enzyme function
- Adipose Tissue and Metabolism
Institut de Recherche sur le Cancer et le Vieillissement de Nice
2024
Centre National de la Recherche Scientifique
2024
Inserm
2019-2024
Shahid Beheshti University of Medical Sciences
2018-2021
Bordeaux Population Health
2019-2021
Université de Bordeaux
2019-2021
Metabolic reprogramming is a common hallmark of cancer, but large variability in tumor bioenergetics exists between patients. Using high-resolution respirometry on fresh biopsies human lung adenocarcinoma, we identified 2 subgroups reflected the histologically normal, paired, cancer-adjacent tissue: high (OX+) mitochondrial respiration and low (OX-) respiration. The OX+ tumors poorly incorporated [18F]fluorodeoxy-glucose showed increased expression trifunctional fatty acid oxidation enzyme...
Tumor cells display metabolic alterations when compared to non-transformed cells. These characteristics are crucial for tumor development, maintenance and survival providing energy supplies molecular precursors. Anaplerosis is the property of replenishing TCA cycle, hub carbon metabolism, participating in biosynthesis precursors building blocks or signaling molecules. In advanced prostate cancer, an upshift succinate-driven oxidative phosphorylation via mitochondrial Complex II was reported....
Abstract The basic understanding of the biological effects eukaryotic translation initiation factors (EIFs) remains incomplete, notably for their roles independent protein translation. Different EIFs exhibit nuclear localization and DNA-related functions have been proposed, but novel beyond lacks integrative analyses between genomic proteomic levels. Here, noncanonical function EIF3F was studied in human lung adenocarcinoma by combining methods that revealed both protein–protein protein–DNA...
Aims: REDOX signaling from reactive oxygen species (ROS) generated by the mitochondria (mitochondrial [mtROS]) has been implicated in cancer growth and survival. Here, we investigated effect of 5-(4-methoxyphenyl)-3H-1,2-dithiole-3-thione (AOL), a recently characterized member new class mtROS suppressors (S1QELs), on human lung adenocarcinoma proteome reprogramming, bioenergetics, growth. Results: AOL reduced steady-state cellular ROS levels cells without altering catalytic activity complex...
Abstract Metastatic triple-negative breast cancers (TNBC) are among the most aggressive types of cancer and often treated with adjuvant radiotherapy chemotherapy. Despite initial efficacy, relapses common, leading to poor prognosis. Understanding response tumor microenvironment is crucial, particularly comparing photon (X) proton (P) due radiation’s reduced side effects. Methods We investigated effects single multiple X P irradiations on various cell within microenvironment, including...
Abstract The human epidermal growth factor 2 (HER2) gene undergoes various mutations that could alter its activity or respond to the antibody therapies. Cetuximab, a known anti‐EGFR monoclonal (mAB), is widely administered in metastatic colorectal cancer (mCRC) cases. Here we identified mCRC patients who did not cetuximab (500 mg/m , q2w) after fluoropyrimidine/oxaliplatin regimen failure. Tumor samples were examined with immunohistochemistry for protein distribution, polymerase chain...
Lung cancer is the leading cause of death worldwide, and tobacco smoking a recognized major risk factor for lung tumor development. We analyzed effect tobacco-specific nitrosamines (TSNAs) on human adenocarcinoma metabolic reprogramming, an emergent hallmark carcinogenesis.
ABSTRACT Rationale Multiple Myeloma (MM) stands as the second most common hematological malignancy characterized by accumulation of monoclonal plasmocytes within bone marrow. Despite introduction proteasome inhibitors, immunomodulatory agents and CD38-targeting antibodies which have extended survival rates, disease remains incurable for patients due to emergence resistant clones frequent relapses. The efficacy inhibitor bortezomib (BTZ) in MM treatment underscores critical role ubiquitin...
Abstract Background Multiple Myeloma (MM) is the second most common hematological malignancy, characterized by accumulation of monoclonal plasmocytes in bone marrow. Despite advancements with proteasome inhibitors, immunomodulatory agents, and CD38-targeting antibodies, MM remains largely incurable due to resistant clones frequent relapses. The success inhibitor bortezomib (BTZ) treatment highlights critical role ubiquitin–proteasome system (UPS) this disease. Deubiquitinases (DUBs), which...
Background: Since the onset of COVID-19 pandemic, adverse outcomes in patients with orthopaedic surgery have become a major concern for surgeons. In other words, question remains whether should be postponed until patient is fully recovered or early performed. Objectives: The present study sought to answer above questions by examining consequences pertrochanteric fractures proximal femur hip CVOID-19 and comparing findings non-COVID-19 patients. Methods: reports experience surgeons on...