A5057077290- Asthma and respiratory diseases
- Sarcoidosis and Beryllium Toxicity Research
- Immune Cell Function and Interaction
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- T-cell and B-cell Immunology
- Respiratory and Cough-Related Research
- Inhalation and Respiratory Drug Delivery
- Allergic Rhinitis and Sensitization
- Systemic Lupus Erythematosus Research
- HIV Research and Treatment
- Immune Response and Inflammation
- Mast cells and histamine
- Monoclonal and Polyclonal Antibodies Research
- Peptidase Inhibition and Analysis
- Drug-Induced Adverse Reactions
- Mosquito-borne diseases and control
- Lung Cancer Treatments and Mutations
- Viral Infections and Vectors
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Food Allergy and Anaphylaxis Research
- Lung Cancer Diagnosis and Treatment
- Respiratory Support and Mechanisms
- Autoimmune and Inflammatory Disorders Research
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Infectious Diseases and Tuberculosis
Fundación Universitaria Sanitas
2025
Université Claude Bernard Lyon 1
2002-2023
Biologie Tissulaire et Ingénierie Thérapeutique
2023
Hospital Reina Sofía de Murcia
2020-2021
Universidad del Rosario
2016-2020
Hôpital Lyon Sud
2009-2019
Hospices Civils de Lyon
2007-2019
Ragon Institute of MGH, MIT and Harvard
2013-2019
Centre National de la Recherche Scientifique
2013-2016
Inserm
1986-2016
Evidence supports the existence of different subphenotypes in systemic lupus erythematosus (SLE) and pivotal role cytokines autoantibodies, which interact a highly complex network. Thus, understanding how these nonlinear processes are connected observed real-life settings is major challenge. Cluster approaches may assist identification subphenotypes, represent such phenomenon, contribute to development personalized medicine. Therefore, relationship between autoantibody cytokine clusters SLE...
Autoimmune diseases (ADs) are a chronic and clinically heterogeneous group of characterized by share common immunopathogenic mechanisms risk factors (i.e., the autoimmune tautology), which explain fact that one AD may coexist with others polyautoimmunity - PolyA). In present exploratory study, mixed-cluster analysis most rheumatic (ARDs) was done. A total 187 consecutive women established systemic lupus erythematosus (n = 70), rheumatoid arthritis 51), sclerosis 35) Sjögren's syndrome 31)...
Efficient recognition and elimination of HIV-1-infected CD4 + T cells by cytotoxic CD8 (CTLs) require target cell engagement the formation a well-organized immunological synapse. Surface proteins belonging to SLAM family are known be crucial for stabilizing synapse regulating antiviral responses during lymphotropic viral infections. In context HIV-1, there have been reports SLAMF6 down-regulation in cells; however, significance this modulation CTL function remains unclear. investigation, we...
Even with sustained antiretroviral therapy, resting CD4+ T cells remain a persistent reservoir of HIV infection, representing critical barrier to curing HIV. Here, we demonstrate that CD8+ recognize infected, non-activated in the absence de novo protein production, as measured by immune synapse formation, degranulation, cytokine and killing infected cells. Immune recognition is induced HLA-I presentation peptides derived from incoming viral particles, occurred either following cell-free...
French asthma patients may be supervised by general practitioners (GPs) and/or specialists. Therefore, this study examined management in exclusively specialists (SPE), GPs, (GP) and both (GP+SPE group), compared the findings. Asthma were consecutively recruited 348 pharmacies. Each patient completed a questionnaire providing data on personal characteristics, management, perception of disease supervision. control was measured using Control Test. Questionnaires linked to computerised records...
In sensitive patients, aspirin is associated with nasal and bronchial inflammation, eliciting local symptoms. Although the disease clinically well characterized, its physiopathology incompletely understood noninvasive procedures, allowing an effective distinction between aspirin-induced asthma (AIA) aspirin-tolerant (ATA) are missing.The aims of study were to compare AIA ATA cohorts for clinical characteristics screen peripheral blood differential mRNA expression.Patients experiencing...
Abstract Various cosignaling molecules on T cells can contribute to activation, inhibition, or exhaustion, depending context. The surface receptor signaling lymphocytic activation molecule (SLAM) family CD244 (2B4/SLAMf4) has been shown be capable of either inhibitory enhancing effects upon engagement its ligand CD48 (SLAMf2). We examined phenotypes CD8 from HIV+ and HIVneg human donors, specific for HIV and/or respiratory syncytial virus. Cultured ex vivo expressed PD-1, CD244, TIM-3. found...
Systemic lupus erythematosus (SLE) is an autoimmune disease characterised by a breakdown in immune tolerance that induces attack on normal tissues the system. The dysfunction within both innate and adaptive systems increases cytokine production, B lymphocytic overproduction of autoantibodies, T lymphocyte activity. Cytokines inflammatory mediators have been associated with several clinical endpoints, including activity outcomes. In fact, some them different subphenotypes (e.g., nephritis),...
Background: Optimal control is a major objective of disease management asthma. The aim the present study was to provide descriptive data on in asthma patients, including medical resource utilization. Methods: Asthma patients (age 18–50 years) were consecutively recruited 348 dispensing pharmacies. They completed questionnaire which collected personal characteristics, management, utilization, management. measured with Control Test. Data from computerized pharmacy records medications,...
<h3>BACKGROUND</h3> Cystic fibrosis (CF) is a genetic disease caused by mutations in the cystic transmembrane conductance regulator (CFTR) gene and defective expression of CFTR protein epithelial cells. The main cause mortality CF linked to chronic inflammatory infectious airway processes. Recent studies have suggested perturbations apoptotic process cell lines enterocytes. A study was undertaken investigate Fas ligand (FasL) bronchial epithelium tracheal lines. <h3>METHODS</h3>...