A5067251512- Medical Imaging Techniques and Applications
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Lanthanide and Transition Metal Complexes
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Advanced MRI Techniques and Applications
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Medical Imaging and Pathology Studies
- Particle accelerators and beam dynamics
- Advanced Radiotherapy Techniques
- Muon and positron interactions and applications
- Advanced Nanomaterials in Catalysis
- Quantum Dots Synthesis And Properties
- Nanocluster Synthesis and Applications
- Hepatocellular Carcinoma Treatment and Prognosis
- Angiogenesis and VEGF in Cancer
- Nitric Oxide and Endothelin Effects
- Lymphoma Diagnosis and Treatment
- Drug Transport and Resistance Mechanisms
- Radiation Dose and Imaging
- Boron Compounds in Chemistry
- Radioactive Decay and Measurement Techniques
Virginia Commonwealth University
2013-2023
University Health System
2016-2023
VCU Massey Comprehensive Cancer Center
2019-2020
Children's Hospital of Richmond at VCU
2018-2020
Virginia Cancer Institute
2019-2020
University of Richmond
2014-2016
University of Manchester
1988-2008
Cancer Research UK Manchester Institute
2001-2007
The Christie NHS Foundation Trust
2001-2007
Cancer Research UK
2005-2006
Vascular endothelial growth factor (VEGF) is a potent angiogenic cytokine, and various inhibitory agents, including specific antibodies, have been developed to block VEGF-stimulated angiogenesis. We HuMV833, humanized version of mouse monoclonal anti-VEGF antibody (MV833) that has antitumor activity against number human tumor xenografts, investigated the distribution biologic effects HuMV833 in patients phase I trial.Twenty with progressive solid tumors were treated doses (0.3, 1, 3, or 10...
High-resolution three-dimensional (3-D) positron emission tomography (PET) scanners with high count rate performance, such as the quad-high density avalanche chamber (HIDAC), place new demands on image reconstruction algorithms due to large quantities of high-precision list-mode data which are produced. Therefore, a algorithm is required can, in practical time frame, reconstruct into very arrays (submillimeter voxels, range over field view) whilst preferably retaining precision data. This...
Methodology for PET system modeling using image-space techniques in the expectation maximization (EM) algorithm is presented. The approach, applicable to both list-mode data and projection data, of particular significance EM implementations which otherwise only use basic models (such as those calculate matrix elements on fly). A version proposed technique can be implemented convolution, order include resolution effects into matrix, so that gradually recovers modeled with each update....
Positron emission tomography (PET) is a powerful diagnostic/imaging technique requiring the production of short-lived positron emitting isotopes 11C, 13N, 15O and 18F by proton irradiation natural/enriched targets using cyclotrons. The development PET has been hampered due to size shielding requirements nuclear installations. Recent results show that when an intense laser beam interacts with solid targets, megaelectronvolt (MeV) protons capable producing are generated. This report describes...
Abstract Here, evidence suggests that nitric oxide synthases (NOS) of tumor cells, in contrast with normal tissues, synthesize predominantly superoxide and peroxynitrite. Based on high-performance liquid chromatography analysis, the underlying mechanism for this uncoupling is a reduced tetrahydrobiopterin:dihydrobiopterin ratio (BH4:BH2) found breast, colorectal, epidermoid, head neck tumors compared tissues. Increasing BH4:BH2 reconstitution coupled NOS activity breast cancer cells BH4...
Primary ciliary dyskinesia (PCD), resulting from defects in cilia assembly or motility, is caused by mutations a number of genes encoding axonemal proteins. PCD phenotypes are variable, and include recurrent respiratory tract infections, bronchiectasis, hydrocephaly, situs inversus, male infertility. We generated knockout mice for the sperm-associated antigen-17 (Spag17) gene, which encodes central pair (CP) protein present axonemes cells with "9 + 2" motile flagella. The targeting Spag17...
In a phase II study, 43 renal cell carcinoma patients were treated with individualised doses of ABR-214936; fusion Fab recognising the antigen 5T4, and Staphylococcal enterotoxin A. Drug was given intravenously on 4 consecutive days, treatment repeated 1 month later. Treatment associated moderate fever nausea, but well tolerated. Of 40 evaluable patients, 28 had disease control at 2 months, one patient showed partial response (PR) 16 stable disease. Median survival, minimum follow-up 26...
Cerium oxide nanoparticles (CONPs) have demonstrated protection properties against oxidation in various cells and tissues. The mechanism of this, however, is poorly understood. Monitoring the interaction CONPs with biological compartments 'in situ' crucial to understand their biochemical physiological vivo. In this paper, a multifunctional nanoparticle platform was obtained through an intrinsic radiolabeling strategy extrinsic surface functionalization combine dual imaging components (Single...
The overall objective of this study is to non-invasively image and assess tumor targeting retention directly labeled T-lymphocytes following their adoptive transfer in mice. obtained from draining lymph nodes 4T1 (murine breast cancer cell) sensitized BALB/C mice were activated in-vitro with Bryostatin/Ionomycin for 18 hours, grown the presence Interleukin-2 6 days. then 1,1-dioctadecyltetramethyl indotricarbocyanine Iodide (DiR), a lipophilic near infrared fluorescent dye that labels cell...
Radiolabeled liposomes have been employed as diagnostic tools to monitor in vivo distribution of real-time, which helps optimizing the therapeutic efficacy liposomal drug delivery. This work utilizes platform [111In]-Liposome a delivery vehicle, encapsulating novel 18F-labeled carboplatin derivative ([18F]-FCP) dual-molecular imaging tool both radiolabeled and carrier. The approach has potential for clinical translation individual patients using dual modal clinically-relevant radionuclides...
We have previously shown that labelled water positron emission tomography (H2(15)O PET) can be used to identify regional cerebral blood flow (rCBF) changes in the human brain during volitional swallowing. (18F) fluorodeoxyglucose (FDG PET), by comparison, uses a glucose analogue quantitatively measure metabolism (rCMRglc) rather than rCBF. The main advantage of FDG PET is improved spatial resolution, and because its pharmacodynamic properties, activation performed external scanner, allowing...