A5103244320- Radiopharmaceutical Chemistry and Applications
- Neuroscience and Neuropharmacology Research
- Medical Imaging Techniques and Applications
- Treatment of Major Depression
- HIV/AIDS drug development and treatment
- HIV Research and Treatment
- HIV/AIDS Research and Interventions
- Pharmacological Receptor Mechanisms and Effects
- Neurotransmitter Receptor Influence on Behavior
- Chemical Synthesis and Characterization
- Nuclear Physics and Applications
- Particle accelerators and beam dynamics
- Herpesvirus Infections and Treatments
- Muon and positron interactions and applications
- Infectious Encephalopathies and Encephalitis
- Parkinson's Disease Mechanisms and Treatments
- Chemical Synthesis and Analysis
- Cyclopropane Reaction Mechanisms
- Receptor Mechanisms and Signaling
- Immunotherapy and Immune Responses
- Electroconvulsive Therapy Studies
- Radioactive contamination and transfer
- PARP inhibition in cancer therapy
- Boron Compounds in Chemistry
- Cardiac, Anesthesia and Surgical Outcomes
Wayne State University
2013-2022
Northwestern University
2022
Eugene Applebaum College of Pharmacy and Health Sciences
2013-2016
University of Tennessee Health Science Center
2011-2013
University of Tennessee at Knoxville
2012
University of Manchester
1980-1992
Institute of Cancer Research
1986
University of Birmingham
1986
Cancer Research UK Manchester Institute
1985
In the present study, we report exploration of binding modes potent HIV-1 integrase (IN) inhibitors MK-0518 (raltegravir) and GS-9137 (elvitegravir) as well chalcone related amide IN recently synthesized development 3D-QSAR models for inhibition. Homology DNA-bound were constructed on basis X-ray crystal structure foamy virus IN-DNA complex (PDB ID: 3L2T ) used docking. The raltegravir elvitegravir in our homology are accordance with those revealing interactions important inhibitor-IN...
Major depressive disorder (MDD) is a debilitating disease affecting wide cross section of people around the world. The current therapy for depression less than adequate and there considerable unmet need more efficacious treatment. Dopamine has been shown to play significant role in including production anhedonia which one untreated symptoms MDD. It hypothesized that drugs acting at all three monoamine transporters dopamine transporter should provide antidepressants activity. This led...
Major depressive disorder is a critical public health problem with lifetime prevalence of nearly 17% in the United States. One potential therapeutic target interaction between hyperpolarization-activated cyclic nucleotide-gated (HCN) channels and an auxiliary subunit channel named tetratricopeptide repeat-containing Rab8b-interacting protein (TRIP8b). HCN regulate neuronal excitability mammalian hippocampus, recent work has established that antagonizing function rescues cognitive impairment...
The present study reports the 3D QSAR of dopamine D2/D3 ligands to gain insights into structural factors responsible for affinity and D3 selectivity.
Positron emission tomography of patients with hyperthyroidism using 124I has proved considerably successful and the data show (Ott el al. J. Nucl. Med., vol.26, p.30-1, 1985) radically improved measurements distribution radiation dose from radioactive iodine used therapeutically can be obtained high-resolution positron camera. From results presented here, it is clear that a measurement impurities in important determining overall to thyroid.
Unipolar depression, caused by an imbalance of monoamine neurotransmitters in brain, is ranked as the most prevalent all somatic and psychiatric illness. It estimated that about 40 % patients remains refractory to treatment thereby limiting use current antidepressant drugs. Moreover, because relapse unwanted side effects existing drugs there unmet need discover novel agents for this devastating mental disorder. Current aims at alleviating extraneuronal concentration serotonin (5-HT) /or...
Summary A proportion of syngeneic female rats inoculated intramuscularly with a lethal T-cell lymphoblastic (Roser) leukaemia are cured by single intraperitoneal injection bischloroethylnitrosourea (BCNU) (Carmustine) (10 mg kg-1) given towards the end preleukaemic phase (day 7). Additional therapy on day 4, using intravenous cells lethally labelled radionuclide 114Inm, enhanced overall cure rate 30%. The spleen is major site indium concentration from targeting so that continuous local...