A5040352913- Multicomponent Synthesis of Heterocycles
- Neuroscience and Neuropharmacology Research
- Treatment of Major Depression
- Chemical Synthesis and Analysis
- Synthesis and Biological Evaluation
- Neurotransmitter Receptor Influence on Behavior
- Chemical synthesis and alkaloids
- Carbohydrate Chemistry and Synthesis
- Microwave-Assisted Synthesis and Applications
- Synthetic Organic Chemistry Methods
- Asymmetric Synthesis and Catalysis
- X-ray Diffraction in Crystallography
- Sulfur-Based Synthesis Techniques
- Advanced Synthetic Organic Chemistry
- Receptor Mechanisms and Signaling
- Crystallization and Solubility Studies
- Synthesis and pharmacology of benzodiazepine derivatives
- Water Quality Monitoring Technologies
- Synthesis and Biological Activity
- Click Chemistry and Applications
- Synthesis of Organic Compounds
- Tryptophan and brain disorders
- Cyclopropane Reaction Mechanisms
- Catalytic Cross-Coupling Reactions
- Synthesis and biological activity
Lovely Professional University
2019-2025
Wayne State University
2008-2022
Eugene Applebaum College of Pharmacy and Health Sciences
2013-2014
University of Calcutta
2009
Whole in one! A one-pot microwave-assisted reaction sequence that consists of an Ugi/Michael/aza-Michael transformation gives access to quaternary spirocenters leading Amaryllidaceae and Erythrina alkaloid like compounds (see scheme). The process produces four stereogenic centers six contiguous bonds, provides products with good excellent yields appreciable diastereoselectivity.
Small molecule diversity can be achieved in a single synthetic operation from bifunctional substrates the absence of additives and under influence microwaves with complete control pathway selectivity. The preliminary Ugi four-component coupling products give rise to three structurally distinct scaffolds that are dependent on solvent effects sterics. 2,5-Diketopiperazines (Type A), 2-azaspiro[4.5]deca-6,9-diene-3,8-diones B), thiophene-derived Diels-Alder tricyclic lactams C) predominate this...
A one-pot, two-step synthesis of the title compounds employs a multicomponent Ugi condensation reaction, microwave irradiation, and Fe(0) as reductant. Two pathways are accessible; both routes utilize bifunctional, o-nitro-substituted arenes leading to either C2, N4, C5 substitution (A) or N4 (B).
Abstract Heterocyclics particularly those containing oxygen and nitrogen atoms are unique precursors for the synthesis of various agrochemicals pharmaceuticals. Bis-coumarins well-known oxygen-containing heterocycles great significance. The development methods to prepare bis-coumarins is interest in synthetic organic chemistry because their versatile importance medicinal chemical biology. well known antibiotic, antimicrobial, anti-HIV, antitumor activity. Due vast application bis-coumarins,...
A rapid, cascade reaction process has been developed to access biologically validated spiro-2,5-diketopiperazines. The facile and environmentally benign method capitalizes on commercially available starting reagents for a sequential Ugi/6-exo-trig aza-Michael reaction, water as solvent, microwave irradiation without any extraneous additives.
In this article, we have demonstrated the in vivo efficacy of D-512 and D-440 a 6-OHDA-induced unilaterally lesioned rat model experiment, Parkinson's disease animal model. is novel highly potent D2/D3 agonist, selective D3 agonist. We evaluated neuroprotective properties dopaminergic MN9D cells. Cotreatment these two drugs with 6-OHDA MPP+ significantly attenuated reversed 6-OHDA- MPP+-induced toxicity dose-dependent manner The inhibition caspase 3/7 lipid peroxidation activities along...
Reaktionskaskade: Eine mikrowellenunterstützte Sequenz aus Ugi-, Michael- und Aza-Michael-Reaktion führt zu quartären Spirozentren Amaryllidaceae- Erythrina-Alkaloid-artigen Verbindungen (siehe Schema). Die erzeugt vier stereogene Zentren sechs benachbarte Bindungen; die Produkte werden diastereoselektiv in guten bis exzellenten Ausbeuten erhalten.
Abstract Heterocyclic compounds in particular siloles which a carbon atom has been replaced by an isovalent silicon atom, gained wide attention recently. Due to their unique and interesting electronic aggregation‐induced emmision properties, they found practical application many areas. The properties of depend upon the nature subsituents present on ring. Therefore, synthetic methods strategies continued evolve since first report. advances synthesis siloles, mechanistic details, substituents...
To investigate structural alterations of the lead triple uptake inhibitor molecule, disubstituted 4-((((3S,6S)-6-benzhydryltetrahydro-2H-pyran-3-yl)amino)methyl)phenol, we have carried out structure−activity relationship (SAR) studies to effect alteration aromatic substitutions and introduction heterocyclic moieties on this molecular template. The novel compounds were tested for their affinities dopamine transporter (DAT), serotonin (SERT), norepinephrine (NET) in brain by measuring potency...
Abstract Baker's yeast was primarily used as a leavening agent in the food processing industry and later biocatalyst brewing industry. Ready availability low cost has made baker's primary research object among scientific community. It is well known to reduce carbonyl groups. Several other simple single step transformations have also been carried out using yeast. Multicomponent reactions are close fit concept of “ideal” synthesis and, recent years, they become rapid platform for drug...
[reaction: see text] Diastereoselective reductive coupling reactions of omega-vinyl tethered cyclic imides are achieved by a preexisting stereocenter at an allylic position. Particularly noteworthy is the effective use 1:2 mixture Ti(O-i-Pr)4 and n-BuLi to afford N-acylhemiaminal products in good yields.
Major depressive disorder (MDD) is a debilitating disease affecting wide cross section of people around the world. The current therapy for depression less than adequate and there considerable unmet need more efficacious treatment. Dopamine has been shown to play significant role in including production anhedonia which one untreated symptoms MDD. It hypothesized that drugs acting at all three monoamine transporters dopamine transporter should provide antidepressants activity. This led...
Abstract To further explore the basic structural motifs (3 S ,6 )‐6‐benzhydryl‐ N ‐benzyltetrahydro‐2 H ‐pyran‐3‐amine and (2 ,4 R ,5 )‐2‐benzhydryl‐5‐(benzylamino)tetrahydro‐2 ‐pyran‐4‐ol, developed by our research group, for monoamine transport inhibition, we designed synthesized various structurally altered analogues. The new compounds were tested their affinities dopamine transporter (DAT), serotonin (SERT), norepinephrine (NET) in rat brain measuring capacity to inhibit uptake of [ 3...
Guar gum (GG) is a natural heteropolysaccharide. Due to its non-toxic, eco-friendly, and biodegradable nature, GG has found wide applications in many areas, particular food, paper, textile, petroleum, pharmaceutical industries. Therefore, often called "Black Gold" as well. the presence of hydroxyl groups, can be modified by various methods. The physical biological properties modulated chemical modifications. In this manuscript, methods for modifications have been discussed according type...
Corrected by: Burgess Reagent: From Oblivion to Renaissance in Organic SynthesisSynlett 2009; 2009(05): 852-852DOI: 10.1055/s-0028-1088204
Thiocoumarins and dithiocoumarins are two important classes of sulphurcontaining heterocyclic compounds, which bioisosteres coumarins. Herein, various synthetic strategies for these compounds reported in the literature have been discussed. Different solvents, catalysts, reagents reaction conditions, were employed successfully synthesizing thiocoumarins also described concisely this review. Mechanistic overview has given wherever it was necessary. In addition, a comparative view catalysts...