Abstract In the last few decades, transition metal‐catalyzed activation of inert C−H bonds has led to a fundamental change in field synthetic chemistry. Most these reactions deal with simple functionalizations or additions. However, recent years have witnessed an increase bond and annulation reactions. These are appealing organic chemist as they afford highly valuable cyclic compounds rapid sustainable manner from readily available compounds. This review article attempts highlight advances...

Abstract Being an important constituent of naturally occurring lactones with diverse biological activities and as a pivotal intermediate in heterocycle synthesis, the isocoumarin motif has claimed vast interest synthetic medicinal research. The methodologies for synthesis isocoumarins involve particularly metal‐catalyzed reactions well various intramolecular intermolecular cyclization reactions. transition metal complexes palladium, copper, rhodium, ruthenium, iridium, nickel, zinc silver...

Abstract In recent years, the transition‐metal‐catalyzed functionalization reactions of sulfoxonium ylides have been explored extensively because their usefulness as carbene‐transfer agents, since they can produce metal carbenes through catalysis. Moreover, are safer and advantages simple handling good stability over other counterparts like diazo‐compounds. This review article attempts to highlight advances in metal‐catalyzed C−H ylides.

β-(3-Hydroxypyrazol-1-yl) ketones have been prepared in high yields and excellent enantioselectivities (94−98% ee) via a Michael addition reaction between 2-pyrazolin-5-ones aliphatic acyclic α,β-unsaturated using 9-epi-9-amino-9-deoxyquinine as the catalyst. These results account for first example of an aza-Michael ambident 2-pyrazolin-5-one anion to acceptor.

An unprecedented annulation reaction is developed for the synthesis of dihydrofuran-fused compounds. In this Ru-catalyzed hydroxyl-group-directed reaction, easily affordable sulfoxonium ylides and 1,4-dioxane were used as annulating partners. This first example use a methylene source to construct heterocyclic scaffold. A wide range dihydrofuran0fused coumarins naphthalenes synthesized using three-component reaction.

An efficient method was developed for the synthesis of pyrazole fused heterocycles <italic>via</italic> palladium-catalyzed solvent free reaction β-halovinyl/aryl aldehydes and 3-aminopyrazoles/5-aminopyrazoles under microwave irradiation in good yields.

An Ru(<sc>ii</sc>) catalyst was used for the annulation reaction of terminal/disubstituted alkynes with salicylaldehydes to afford chromones.

Abstract The first decarbonylative insertion of an alkyne through C−H/C−C activation six‐membered compounds is reported. Ru‐catalyzed reaction 3‐hydroxy‐2‐phenyl‐chromones with alkynes works most efficiently in the presence ligand PPh 3 to provide spiro‐indenebenzofuranones. Unlike previously reported metal‐catalyzed annulation reactions, present reaction, occurs before extrusion carbon monoxide.

An inexpensive ruthenium(II) complex enabled oxidative annulation of alkynes by using cinnamic acid derivatives to provide diversely decorated multisubstituted α-pyrones.

An unprecedented Ru(II)-catalyzed carbonylative annulation reaction of phenyl-phthalazinediones and phenyl-indazolones is developed. In this reaction, sulfoxonium ylide used as the carbonyl source in presence air for the...

The experiment was carried out during 2023-24 at the department of Life Sciences, Sibsagar University, Assam to observe effect application vermicompost and vermiwash on growth bean plants. Vermicompost prepared by using earthworm, Eisenia foetida. Vermiwash from same vermibed. It observed that throughout plants grew well gradually with increasing amount as compared control shoot length common plant, Phaseolus vulgaris found maximum i. e. 25.37 +1.81 cm in 700 g 300 soil. Maximum root 11.93...

The amide C–N bond of isatins was used as the oxidizing directing group for 4C–H activation and annulation reactions with alkynes.

The first example of a ruthenium catalyzed decarbonylative addition reaction anhydrides with disubstituted alkynes is reported.

A new carbon–carbon bond cleavage reaction was developed for the efficient synthesis of multisubstituted pyrazolo[1,5-a]pyrimidines. This base induced 1,3,5-trisubstituted pentane-1,5-diones and substituted pyrazoles afforded good yields

An unprecedented Ru(II)-catalyzed C–H activation and annulation reaction, which proceeds via C–C triple bond cleavage, is reported. This reaction of 2-phenyldihydrophthalazinediones with alkynes, works most efficiently in the presence bidented ligand 1,3-bis(diphenylphosphino)propane, affords good yields substituted quinazolines.

The first metal-catalyzed double aryl C(sp2)–H bond activation of antipyrine and alkyne annulation reaction is reported. This Ru(II)-catalyzed was accomplished in the presence 20 mol % phosphine ligand tricyclohexylphosphine tetrafluoroborate to afford indolo[2,1-a]isoquinolines that are very important compounds because their bioactivity interesting optical properties.

A wide range of 3-substituted isoquinolines, steroidal pyridines, 5,6-dihydrobenzo[f]isoquinolines and 1,6-naphthyridine were synthesized in good yield via a ligand-free copper-catalyzed three-component reaction β-halovinyl/aryl aldehyde, aromatic/aliphatic terminal alkyne tert-butylamine/benzamidine DMF under microwave irradiation. catalyst-free ortho-alkynyl aryl/vinyl aldehydes with benzamidine irradiation also provided the isoquinoline substituted pyridine derivatives excellent yield.

Ru(<sc>ii</sc>)-Catalyzed annulation reaction of benzamidines and disubstituted alkynes affords 1-aminoisoquinolines.

Grey matters! D-390 (shown) is a dopamine D2/D3 receptor agonist that chelates iron and possesses antioxidant activity. This compound exhibited efficacious activity in an animal model of Parkinson's disease, indicating blood–brain barrier penetration. In mouse MPTP neuroprotection model, significant neuroprotection, its possible therapeutic application both the symptomatic neuroprotective treatment disease. Parkinson′s disease (PD) progressive neurodegenerative disorder characterized by...

Abstract Spirocyclic compounds represent an imperative class of naturally occurring substances characterized by their potential biological properties. They receive much attention as scaffolds in modern drug discovery programs and widespread applications asymmetric organic synthesis chiral catalysts ligands because structural rigidity excellent stereochemical recognition. With the advent C−H activation/annulation, enters into a new dimension with formation novel spiro cycles. The present...

This report describes development of a series novel bivalent molecules with pharmacophore derived from the D2/D3 agonist 5-OH-DPAT. Spacer length in compounds had pronounced influence on affinity for D2 receptors. A 23-fold increase was observed at spacer 9 or 10 (compounds 11d and 14b) compared to monovalent 5-OH-DPAT (Ki; 2.5 2.0 vs. 59 nM 14b 5-OH-DPAT, respectively). Functional potency indicated 24- 94-fold receptor (EC50; 1.7 0.44 41 These are most potent agonists known date. synergism...

Abstract The self‐assembly of the precatalyst modules, which are amino acids and cinchona alkaloid derivatives, leads to direct formation desired organocatalysts without any synthesis. These modularly designed (MDOs) may be used for catalyzed asymmetric aldol reaction. Depending on structure aldehyde substrates, corresponding products obtained in mediocre excellent ee values (up 92% ) with moderate diastereoselectivities 79:21 dr ).