[reaction: see text] The microwave-mediated three-component reaction of acyl bromide, pyridine, and acetylene is catalyzed by basic alumina to give corresponding indolizines in excellent yields a one-pot reaction.

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTStudies on uracils. 10. A facile one-pot synthesis of pyrido[2,3-d]- and pyrazolo[3,4-d]pyrimidinesPulakjyoti Bhuyan, Romesh Chandra Boruah, Jagir Singh SandhuCite this: J. Org. Chem. 1990, 55, 2, 568–571Publication Date (Print):January 1, 1990Publication History Published online1 May 2002Published inissue 1 January 1990https://pubs.acs.org/doi/10.1021/jo00289a033https://doi.org/10.1021/jo00289a033research-articleACS PublicationsRequest reuse...

Abstract A facile and efficient procedure for the ipso ‐hydroxylation of arylboronic acids to phenols in water was developed. series electron‐rich electron‐deficient were smoothly ‐hydroxylated with this protocol afford products excellent yields. Moreover, is amenable boronate esters. In most cases, phenolic obtained pure form without any chromatographic purification.

An efficient method was developed for the synthesis of pyrazole fused heterocycles <italic>via</italic> palladium-catalyzed solvent free reaction β-halovinyl/aryl aldehydes and 3-aminopyrazoles/5-aminopyrazoles under microwave irradiation in good yields.

The first example of a ruthenium catalyzed decarbonylative addition reaction anhydrides with disubstituted alkynes is reported.

A new carbon–carbon bond cleavage reaction was developed for the efficient synthesis of multisubstituted pyrazolo[1,5-a]pyrimidines. This base induced 1,3,5-trisubstituted pentane-1,5-diones and substituted pyrazoles afforded good yields

An unprecedented Ru(II)-catalyzed C–H activation and annulation reaction, which proceeds via C–C triple bond cleavage, is reported. This reaction of 2-phenyldihydrophthalazinediones with alkynes, works most efficiently in the presence bidented ligand 1,3-bis(diphenylphosphino)propane, affords good yields substituted quinazolines.

A wide range of 3-substituted isoquinolines, steroidal pyridines, 5,6-dihydrobenzo[f]isoquinolines and 1,6-naphthyridine were synthesized in good yield via a ligand-free copper-catalyzed three-component reaction β-halovinyl/aryl aldehyde, aromatic/aliphatic terminal alkyne tert-butylamine/benzamidine DMF under microwave irradiation. catalyst-free ortho-alkynyl aryl/vinyl aldehydes with benzamidine irradiation also provided the isoquinoline substituted pyridine derivatives excellent yield.

A three-component cascade method has been developed for the direct synthesis of polysubstituted pyridines. This strategy provides a very convenient route to pyridines using variety β-bromo-α,β-unsaturated aldehydes, 1,3-diketones, and ammonium acetate without any additional catalyst or metal salt under mild conditions. β-ketoesters 4-hydroxycoumarin were also used instead 1,3-diketones diverse polycyclic One synthesized unambiguously established by single crystal XRD study. All pyridine...

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTA Comparison of the Cytotoxic and Physical Properties Aziridinyl Quinone Derivatives Based on Pyrrolo[1,2-a]benzimidazole Pyrrolo[1,2-a]indole Ring SystemsRomesh C. Boruah Edward B. SkiboCite this: J. Med. Chem. 1994, 37, 11, 1625–1631Publication Date (Print):May 1, 1994Publication History Published online1 May 2002Published inissue 1 1994https://pubs.acs.org/doi/10.1021/jm00037a013https://doi.org/10.1021/jm00037a013research-articleACS...

A new general method for the deoxygenation of N-oxides such as N-arylnitrones, azoxybenzenes, and N-heteroarene uses aluminum iodide in acetonitrile. The deoxygenated products are obtained high yields.

Abstract A facile, efficient, ligand‐free Suzuki–Miyaura reaction of β‐halo α,β‐unsaturated aldehydes with boronic acids in aqueous media at room temperature is described. Under the optimized conditions, both steroidal and nonsteroidal reacted rapidly to provide a series aryl‐substituted derivatives excellent yields. Moreover, protocol was extended direct one‐pot synthesis polycyclic aromatic hydrocarbons through cross‐coupling/aldol condensation cascade under microwave irradiation.

Abstract An efficient palladium(II)‐catalyzed method for the synthesis of alkylated pyridine‐substituted pyrroles has been developed by a one‐pot three component reaction β ‐bromovinyl aldehydes, primary amines and 2‐alkynylpyridines in good yields. The reactions can also provide an route to 2‐picolinoylpyrroles slightly altering conditions. magnified image

A new approach for the synthesis of pyrido[2,3-<italic>d</italic>]pyrimidines <italic>via</italic> cascade imination/Buchwald–Hartwig cross coupling/cycloaddition reactions is described.

The influence of structure on DT-diaphorase substrate activity, topoisomerase II inhibition and DNA reductive alkylation was studied for the 6-aziridinylpyrrolo[1,2-a]benzimidazolequinones (PBIs) 6-acetamidopyrrolo[1,2-a]benzimidazolequinones (APBIs). PBIs are reductively activated by alkylate phosphate backbone via major groove interactions, while APBIs inactivated this enzyme since only quinone form inhibits II. Bulk at 7-position (butyl instead methyl) significantly decreases kcat/Km...