A5028287052- Cancer Immunotherapy and Biomarkers
- Esophageal Cancer Research and Treatment
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- Neuroendocrine Tumor Research Advances
- Immunotherapy and Immune Responses
- T-cell and B-cell Immunology
- Cardiovascular Health and Risk Factors
- Lung Cancer Research Studies
- Cancer Genomics and Diagnostics
- Inflammatory Biomarkers in Disease Prognosis
- RNA modifications and cancer
- Molecular Biology Techniques and Applications
- Neuroblastoma Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Lung Cancer Diagnosis and Treatment
- vaccines and immunoinformatics approaches
- Medical Imaging Techniques and Applications
- AI in cancer detection
- Cancer Research and Treatments
- Metastasis and carcinoma case studies
- Cancer, Lipids, and Metabolism
- Clinical Laboratory Practices and Quality Control
- PARP inhibition in cancer therapy
- Medical Coding and Health Information
Cardiff and Vale University Health Board
2013-2024
Federal University Wukari
2024
Federal University Lafia
2024
University Hospital of Wales
2013-2021
Cardiff University
2013-2020
West Virginia University Hospitals
2015
Heidelberg University
2012
Although elevated CD4⁺Foxp3⁺ regulatory T cell (Treg) frequencies within tumors are well documented, the functional and phenotypic characteristics of CD4⁺Foxp3⁻ subsets from matched blood, healthy colon, colorectal cancer require in-depth investigation. Flow cytometry revealed that majority intratumoral cells (Tregs) were Helios⁺ expressed higher levels cytotoxic T-lymphocyte antigen 4 (CTLA-4) CD39 than Tregs colon blood. Moreover, ∼30% markers associated with functions, including...
Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare diagnosis, mainly encountered in the gastro-entero-pancreatic tract. There limited knowledge of its epidemiology, prognosis and biology, best management for affected patients still to be defined.To investigate clinical-pathological characteristics, treatment modalities survival outcomes retrospective cohort with diagnosis MiNEN.Consecutive histologically proven MiNEN were identified at 5 European centres. Patient data...
Bilateral locked posterior fracture dislocation of the shoulders is one least common injuries shoulder, and this injury has been suggested to be pathognomonic seizures when diagnosed in absence trauma. The authors present a case idiopathic bilateral dislocations along with review medical literature. also "triple E syndrome," describing possible etiologies injury: epilepsy (or any convulsive seizure), electrocution, or extreme
The demand for businesses to develop new methods generate value and distribute it consumers is rising in the highly challenging global market recent times. This has forced development of more effective efficient warehousing techniques shipping industry. study empirically investigated role logistics performance companies Nigeria. Data were obtained from registered enterprises warehouse operators Nigeria test hypotheses. Descriptive inferential statistics tools data analysis. conclusions...
The study is aimed to verify Aperio AT2 scanner for reporting on the digital pathology platform (DP) and validate cohort of pathologists in interpretation DP routine diagnostic histopathological services Wales, United Kingdom.This was a large multicenter involving seven hospitals across Wales unique with 22 (largest number) participating. 7491 slides from 3001 cases were scanned Leica reported workstations software e-slide manager. A senior fellow compared reports authorized glass slide...
The aim of this study was to assess the relative prognostic value biomarkers measure systemic inflammatory response (SIR) and improve modeling in a cohort patients undergoing potentially curative surgery for gastric adenocarcinoma. hypothesis that single SIR biomarker would be associated with most value. Consecutive 331 cancer between 2004 2016 within regional UK network were identified. Serum measurements hemoglobin, C-reactive protein, albumin, modified Glasgow Prognostic Score,...
To improve clinical lymph node staging (cN-stage) in oesophageal adenocarcinoma by developing and externally validating three prediction models; one with variables only, positron emission tomography (PET) radiomics a combined model.Consecutive patients fluorodeoxyglucose (FDG) avid tumours treated neoadjuvant therapy between 2010 2016 two international centres (n = 130 n 60, respectively) were included. Four (age, gender, T-stage tumour regression grade) PET from the primary used for model...
Survival and relapse after gastric cancer surgery are largely attributed to tumor biology surgical radicality; yet, other prognostic factors have been reported, including respiratory sepsis anastomotic leakage, but not global morbidity severity score (MSS). The hypothesis tested was that MSS would be associated with both disease-free (DFS) overall survival (OS).
Abstract Background Inflammation has an important role in cancer survival, yet whether serum markers of inflammation predict response to potentially curative neoadjuvant chemotherapy (NAC) oesophageal adenocarcinoma (OAC) is controversial. This study aimed determine the systemic inflammatory (SIR) associated with NAC and survival. Methods Consecutive patients OAC planned for surgery intent received blood neutrophil lymphocyte measurements at diagnosis calculate ratio (NLR). Pathological...
The relationship between the adaptive CD4+ T cell response and human cancer is unclear. oncofetal antigen 5T4 expressed on many carcinomas, including colorectal (CRC) cells, but has limited expression normal tissues. We previously identified anti-5T4 cells in a proportion of CRC patients, we extended this study to examine whether quality or quantity reflects tumor stage. An overlapping peptide library spanning was used as target enumerate cognate IFN-γ+CD4+ T-cells (measured spot forming...
The aim of this study was to assess the relative prognostic value biomarkers measure systemic inflammatory response (SIR) and potentially improve modeling in patients undergoing curative surgery for esophageal adenocarcinoma (EC).Consecutive 330 EC between 2004 2018 within a regional UK cancer network were identified. Serum measurements haemoglobin, C-reactive protein, albumin, modified Glasgow Prognostic Score (mGPS), differential neutrophil lymphocyte ratio (NLR) obtained before surgery,...
The incidence of Human Papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC) is increasing rapidly in the UK. Patients with HPV-positive OPSCC generally show superior clinical responses relative to HPV-negative patients. We hypothesised that these could be associated defective repair DNA double strand breaks (DSB). study aimed determine whether sensitivity inhibition using PARP inhibitor Olaparib. Sensitivity Olaparib, and induction damage, were assessed a panel 8...
Lymphoepithelial cyst of the pancreas is a rare benign lesion that should be managed conservatively. Similarity has been described between lymphoepithelial and branchial neck.We report 58-year-old man presenting with left sided abdominal pain initially thought to renal colic. CT abdomen revealed 3.5 cm in pancreatic tail. A laparoscopic distal pancreatectomy was planned for definitive treatment; however, endoscopic ultrasound guided fine needle aspiration (EUS-FNA) performed prior surgery as...
The oncofoetal antigen 5T4 is a promising T cell target in the context of colorectal cancer, as demonstrated by recent clinical study where 5T4-specific responses, induced vaccination or cyclophosphamide, were associated with significantly prolonged survival patients metastatic disease. Whilst Th1-type (IFN-γ+) responses specific to 5T4, and other antigens, are often readily detectable early stage CRC healthy donors, their activity suppressed cancer progresses CD4+CD25hiFoxp3+ regulatory...
Summary We present a 60-year-old woman who underwent successful surgical resection (partial pancreatectomy) for low grade non-functioning pancreatic neuroendocrine tumour (pNET), with no biochemical or radiological features of recurrence on follow-up visits 5 years. Fourteen years after the initial surgery, she developed spontaneous severe hypoglycaemic episodes which required hospitalisation, subsequent investigations confirming diagnosis metastatic insulin-secreting pNET (insulinoma)....
This pilot study investigated the association of four PET image features and cyclo-oxygenase-2 (COX-2) expression in patients with oesophageal adenocarcinoma. The prognostic significance these biomarkers was also assessed.50 consecutive [median age = 68 (range 47 - 84), males 45) adenocarcinoma had PET/CT staging between January 2011 July 2015. maximum mean standardised uptake values (SUVmax SUVmean), metabolic tumour volume (MTV) lesion glycolysis (TLG) were calculated from primary tumour....
Broadly expressed, highly differentiated tumor-associated antigens (TAA) can elicit antitumor immunity. However, vaccines targeting TAAs have demonstrated disappointing clinical results, reflecting poor antigen selection and/or immunosuppressive mechanisms.
Abstract Small intestine neuroendocrine tumours (SI‐NETs) are often diagnosed late with a UK median of 3 years and high misdiagnosis rates. Previous studies, largely based on patient surveys, offer little data improving diagnosis. In 2017, the South Wales NET service underwent nationally commissioned, systematic transformation, aiming to improve diagnosis through development gastroenterology surgical referral network, education these specialities. This study aims assess impact transformation...