A5029145903- Childhood Cancer Survivors' Quality of Life
- Gastric Cancer Management and Outcomes
- Acute Lymphoblastic Leukemia research
- Helicobacter pylori-related gastroenterology studies
- Global Cancer Incidence and Screening
- BRCA gene mutations in cancer
- Esophageal Cancer Research and Treatment
- Eosinophilic Esophagitis
- Genomics and Rare Diseases
- Heart Failure Treatment and Management
- Family Support in Illness
- Health Systems, Economic Evaluations, Quality of Life
- Diabetes and associated disorders
- Pancreatic function and diabetes
- Lymphoma Diagnosis and Treatment
- Diabetes Management and Research
- Cancer Risks and Factors
- Ovarian cancer diagnosis and treatment
- Pharmaceutical studies and practices
- Multiple and Secondary Primary Cancers
- Vaccine Coverage and Hesitancy
- Advances in Oncology and Radiotherapy
- Gastroesophageal reflux and treatments
- Adolescent and Pediatric Healthcare
- Cancer Genomics and Diagnostics
Boston Children's Hospital
2014-2025
Harvard University
2013-2025
Boston Children's Museum
2020-2025
Northwestern University
2024
St. Joseph Medical Center
2021-2024
UCLA Medical Center
2023
Harbor–UCLA Medical Center
2023
Harvard University Press
2022
Amherst College
2022
Brigham and Women's Hospital
2014-2019
<h3>Importance</h3> Advances in childhood and adolescent cancer treatment have been associated with increased rates of cure during the past 3 decades; however, improvement adult life expectancy for these individuals has not yet reported. <h3>Objectives</h3> To project long-term survival assess whether will improve among survivors who were treated more recent decades. <h3>Design, Setting, Participants</h3> A microsimulation model competing mortality risks was developed using data from...
<h3>Objective</h3> To estimate the cost-effectiveness of noncardia gastric adenocarcinoma (NCGA) screening strategies based on new biomarker and endoscopic technologies. <h3>Design</h3> Using an intestinal-type NCGA microsimulation model, we evaluated following one-time for US men: (1) serum pepsinogen to detect atrophy (with follow-up positive screen results), (2) dysplasia asymptomatic cancer mucosal resection (EMR) treatment detected lesions) (3) <i>Helicobacter pylori</i> treatment....
Screening mammography and magnetic resonance imaging (MRI) are recommended for women with ATM, CHEK2, PALB2 pathogenic variants. However, there few data to guide screening regimens these women.To estimate the benefits harms of breast cancer strategies using MRI at various start ages variants.This comparative modeling analysis used 2 established microsimulation models from Cancer Intervention Surveillance Modeling Network (CISNET) evaluate different strategies. Age-specific risks were...
Gastric cancer is the second leading cause of cancer-related deaths worldwide. Treatment for Helicobacter pylori infection, causal risk factor, can reduce disease progression, but long-term impact on incidence uncertain. Using best available data, we estimated potential health benefits and economic consequences associated with H. screening in a high-risk region China. An empirically calibrated model gastric was used to project reduction lifetime risk, life-expectancy costs (i) single (age...
Childhood cancer survivors treated with cardiotoxic therapies are recommended to have routine cardiac assessment every 1 5 years, but the long-term benefits uncertain.To estimate cost-effectiveness of detect asymptomatic left ventricular dysfunction and angiotensin-converting enzyme inhibitor β-blocker treatment reduce congestive heart failure (CHF) incidence in childhood survivors.Simulation model.Literature, including data from Cancer Survivor Study.Childhood...
In the United States, approximately 12,000 preterm infants are diagnosed with bronchopulmonary dysplasia (BPD) and many of these require supplemental oxygen after initial hospital discharge. children BPD we sought to identify factors associated use discharge, duration use, methods used wean off in home environment.All subjects (n = 420) diagnosis were recruited from a single center Bronchopulmonary Dysplasia Clinic between 2008 2013. Subject information was obtained patient history records,...
The major complications of pelvic inflammatory disease (infertility, ectopic pregnancy, and chronic pain) are the leading cause non-HIV sexually transmitted morbidity in United States.The goal study was to estimate a plausible range for average lifetime cost (PID) its cohort U.S. women reproductive age.We developed state-transition computer-based model simulate natural history PID, incorporating severity infection, number recurrent episodes, treatment setting, risk over time complications....
Background: Although childhood cancer survival rates have dramatically increased, survivors face elevated risk for life-threatening late effects, including secondary cancer. Objective: To estimate the cumulative effect of disease- and treatment-related mortality risks on survivor life expectancy. Design: State-transition model to simulate lifetime clinical course survivors. Setting: Childhood Cancer Survivor Study. Patients: Five-year Measurements: Probabilities death from original...
Although surveillance for Barrett esophagus and other gastrointestinal precancerous conditions is recommended, no analogous guidelines exist gastric lesions. The objective of this study was to estimate the clinical benefits cost-effectiveness treatment endoscopic prevent cancer.The authors developed a state-transition decision model cohort US men with recent incidental diagnosis lesions (dysplasia, intestinal metaplasia, or atrophy). Strategies included 1) 2) referral treatment, varied by...
Health utility, a summary measure of quality life, has not been previously used to compare outcomes among childhood cancer survivors and individuals without history. We estimated health utility (0, death; 1, perfect health) using the Short Form-6D (SF-6D) in (n = 7105) siblings 372) (using Childhood Cancer Survivor Study cohort) general population 12 803) Medical Expenditures Panel Survey). Survivors had statistically significantly lower SF-6D scores than (mean 0.769, 95% confidence interval...
Endoscopic surveillance of patients with Barrett's Esophagus (BE) is recommended to detect esophageal adenocarcinoma (EAC) and its dysplasia precursors, but survival benefits are unclear. Using Surveillance, Epidemiology, End Results (SEER) linked Medicare data, we sought determine the impact a prior BE diagnosis on in EAC.Our analysis focused over age 65 primary EAC diagnosed SEER region from 2000-2011 enrolled Medicare. We identified preexisting compared this group without diagnosis. A Cox...
Importance The lifetime risk of aging-related diseases among survivors childhood cancer, accelerated by cancer treatment exposures, is unknown. Understanding this can provide a more comprehensive assessment long-term health across the lifespan and guide adult care. Objective To estimate risks 8 treatment-related cancers cardiovascular conditions compare them with general population. Design, Setting, Participants Using data from Childhood Cancer Survivor Study national databases, simulation...
Survivors of childhood cancer treated with anthracyclines and/or chest-directed radiation are at increased risk for heart failure (HF). The International Late Effects Childhood Cancer Guideline Harmonization Group (IGHG) recommends risk-based screening echocardiograms, but evidence supporting its frequency and cost-effectiveness is limited.