A5041366158- Lymphoma Diagnosis and Treatment
- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Multiple Myeloma Research and Treatments
- Pesticide Exposure and Toxicity
- Occupational and environmental lung diseases
- Chronic Lymphocytic Leukemia Research
- Toxic Organic Pollutants Impact
- Climate Change and Health Impacts
- Noise Effects and Management
- Viral-associated cancers and disorders
- Acute Lymphoblastic Leukemia research
- Pesticide and Herbicide Environmental Studies
- Effects and risks of endocrine disrupting chemicals
- T-cell and Retrovirus Studies
- Urban Green Space and Health
- Adipokines, Inflammation, and Metabolic Diseases
- Occupational exposure and asthma
- Childhood Cancer Survivors' Quality of Life
- Asthma and respiratory diseases
- Rheumatoid Arthritis Research and Therapies
- Immune Cell Function and Interaction
- Allergic Rhinitis and Sensitization
- Acute Myeloid Leukemia Research
- Cystic Fibrosis Research Advances
Drexel University
2016-2025
Fred Hutch Cancer Center
2008-2021
National Institutes of Health
2001-2021
Women's Health Initiative
2021
National Heart Lung and Blood Institute
2021
Brigham and Women's Hospital
2006-2021
Harvard University
2021
MedStar Health
2021
Howard University
2021
Stanford Health Care
2021
Glyphosate is the most commonly used herbicide worldwide, with both residential and agricultural uses. In 2015, International Agency for Research on Cancer classified glyphosate as "probably carcinogenic to humans," noting strong mechanistic evidence positive associations non-Hodgkin lymphoma (NHL) in some epidemiologic studies. A previous evaluation Agricultural Health Study (AHS) follow-up through 2001 found no statistically significant use cancer at any site.
The International Agency for Research on Cancer (IARC) Monographs Programme identifies chemicals, drugs, mixtures, occupational exposures, lifestyles and personal habits, physical biological agents that cause cancer in humans has evaluated about 1000 since 1971. are written by ad hoc Working Groups (WGs) of international scientific experts over a period 12 months ending an eight-day meeting. WG evaluates all the publicly available information each substance and, through transparent rigorous...
Although pancreatic cancer has an extremely high case fatality rate, little is known about differences in mortality by histologic types. We examined median survival and risk of for endocrine tumors two types exocrine tumors, adenocarcinomas, mucinous tumors.This analysis included 35,276 cases reported to the nine population-based registries participating Surveillance, Epidemiology, End Results program from 1973 2000. Survival among with were compared using Kaplan-Meier plots. Comparative...
Background: An increased rate of non-Hodgkin’s lymphoma (NHL) has been repeatedly observed among farmers, but identification specific exposures that explain this observation proven difficult. Methods: During the 1980s, National Cancer Institute conducted three case-control studies NHL in midwestern United States. These pooled data were used to examine pesticide farming as risk factors for men. The large sample size (n = 3417) allowed analysis 47 pesticides simultaneously, controlling...
Glyphosate is a broad-spectrum herbicide that one of the most frequently applied pesticides in world. Although there has been little consistent evidence genotoxicity or carcinogenicity from vitro and animal studies, few epidemiologic reports have indicated potential health effects glyphosate. We evaluated associations between glyphosate exposure cancer incidence Agricultural Health Study (AHS), prospective cohort study 57,311 licensed pesticide applicators Iowa North Carolina. Detailed...
Background: Nitrate is a widespread contaminant of drinking water, but its potential health effects are unclear. In the body, nitrate reduced to nitrite, which can react with amines and amides by nitrosation form N-nitroso compounds, known animal carcinogens. compound formation inhibited certain nutrients, such as vitamin C, increased meat intake. Methods: We investigated association in public water supplies incident colon rectum cancers case-control study conducted Iowa from 1986 1989....
There are several suspected environmental risk factors for non-Hodgkin lymphoma (NHL). The associations between NHL and chemical exposures have typically been evaluated individual chemicals (i.e., one-by-one).
In an International Lymphoma Epidemiology Consortium pooled analysis, polymorphisms in 2 immune-system-related genes, tumor necrosis factor (TNF) and interleukin-10 (IL10), were associated with non-Hodgkin lymphoma (NHL) risk. Here, 8,847 participants added to previous data (patients diagnosed from 1989 2005 14 case-control studies; 7,999 cases, 8,452 controls) for testing of the TNF –308G>A (rs1800629), lymphotoxin-α (LTA) 252A>G (rs909253), IL10 –3575T>A (rs1800890, rs1800896),...
Background: The risk of rheumatoid arthritis (RA) has been associated with living near traffic; however, there is evidence suggesting that air pollution may not be responsible for this association. Noise, another traffic-generated exposure, studied as a factor RA.Objectives: We investigated proximity to traffic, ambient pollution, and community noise in relation RA the Vancouver Victoria regions British Columbia, Canada.Methods: Cases controls were identified cohort adults was assembled...
Development of CKD may be programmed prenatally. We sought to determine the association childhood with prenatal risk factors, including birth weight, maternal diabetes mellitus (DM), and overweight/obesity. conducted a population-based, case-control study 1994 patients (<21 years age at diagnosis) 20,032 controls in Washington state. linked infant characteristics records from 1987 2008 hospital discharge data used logistic regression analysis assess factors CKD. The prevalence was 126.7...
Abstract Polychlorinated biphenyls (PCB) have been suspected as possible contributors to increasing non-Hodgkin's lymphoma incidence during the latter half of 20th century based on their toxicologic properties and provocative epidemiologic reports. We investigated PCBs other organochlorines risk in a population-based case-control study United States. Congeners (including coplanar congeners), dioxins, furans pesticides or pesticide metabolites were measured plasma 100 untreated cases control...
Farming and agricultural pesticide use has been associated with 2 autoimmune rheumatic diseases, rheumatoid arthritis (RA) systemic lupus erythematosus (SLE). However, risk other residential or work place insecticide is unknown.We analyzed data from the Women's Health Initiative Observational Study (n=76,861 postmenopausal women, ages 50-79 years). Incident cases (n=213: 178 for RA, 27 SLE, 8 both) were identified based on self-report of disease-modifying antirheumatic drugs at year 3...
The authors examined incident glioma and meningioma risk associated with occupational exposure to insecticides herbicides in a hospital-based, case-control study of brain cancer. Cases were 462 195 patients diagnosed between 1994 1998 three US hospitals. Controls 765 admitted the same hospitals for nonmalignant conditions. Occupational histories collected during personal interviews. Exposure pesticides was estimated by use questionnaire, combined pesticide measurement data abstracted from...
Diet plausibly has a role in the aetiology of endometriosis through effects on steroid hormone levels; however, few published studies have examined diet and risk. We evaluated dietary risk factors for population-based case-control study. Cases were 284 Group Health (GH) enrollees aged 18-49 years with newly diagnosed, surgically confirmed between 1996 2001. Controls 660 randomly selected age-matched female GH without history endometriosis. Nutrients food groups assessed using Women's...