A5086028523- Carcinogens and Genotoxicity Assessment
- Epigenetics and DNA Methylation
- Polyamine Metabolism and Applications
- Mass Spectrometry Techniques and Applications
- Glutathione Transferases and Polymorphisms
- DNA Repair Mechanisms
- Chemical Reactions and Isotopes
- Genomics, phytochemicals, and oxidative stress
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Pharmacogenetics and Drug Metabolism
- American Constitutional Law and Politics
- Amino Acid Enzymes and Metabolism
- Nutrition, Genetics, and Disease
- Diet, Metabolism, and Disease
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Pancreatic function and diabetes
- Liver Disease Diagnosis and Treatment
- GABA and Rice Research
- Mitochondrial Function and Pathology
- Metabolism, Diabetes, and Cancer
- Adipose Tissue and Metabolism
- Synthesis and Biological Evaluation
- Asymmetric Synthesis and Catalysis
University of Louisville
2016-2025
University of Louisville Hospital
2000-2024
Kosair Charities
2006-2023
The University of Texas Southwestern Medical Center
2020-2023
Southwestern Medical Center
2022-2023
James Graham Brown Foundation
2009-2019
George C Marshall Foundation
2019
Desert Springs Hospital
2018
University of Würzburg
2007-2013
Center for Food Safety and Applied Nutrition
2010
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTThe Use of Polyphosphoric Acid in the Synthesis 2-Aryl- and 2-Alkyl-substituted Benzimidazoles, Benzoxazoles Benzothiazoles1D. W. Hein, R. J. Alheim, LeavittCite this: Am. Chem. Soc. 1957, 79, 2, 427–429Publication Date (Print):January 1, 1957Publication History Published online1 May 2002Published inissue 1 January 1957https://pubs.acs.org/doi/10.1021/ja01559a053https://doi.org/10.1021/ja01559a053research-articleACS PublicationsRequest reuse...
Journal Article Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 polymorphic NAT2 acetyltransferases Get access David W. Hein, Hein 1 1To whom correspondence should be addressed Search for other works this author on: Oxford Academic PubMed Google Scholar Mark A. Doll, Doll Timothy D. Rustan, Rustan Kevin Gray, Gray Yi Feng, Feng Ronald J. Ferguson, Ferguson Denis M. Grant 2Division Clinical Pharmacology Toxicology, Research Institute, Hospital Sick...
OBJECTIVE Glycogen synthase kinase (GSK)-3β plays an important role in cardiomyopathies. Cardiac-specific metallothionein-overexpressing transgenic (MT-TG) mice were highly resistant to diabetes-induced cardiomyopathy. Therefore, we investigated whether metallothionein cardiac protection against diabetes is mediated by inactivation of GSK-3β. RESEARCH DESIGN AND METHODS Diabetes was induced with streptozotocin both MT-TG and wild-type mice. Changes energy metabolism–related molecules, lipid...
Humans exhibit genetic polymorphism in NAT2 resulting rapid, intermediate and slow acetylator phenotypes. Over 65 variants possessing one or more SNPs the 870-bp coding region have been reported. The seven most frequent are rs1801279 (191G>A), rs1041983 (282C>T), rs1801280 (341T>C), rs1799929 (481C>T), rs1799930 (590G>A), rs1208 (803A>G) rs1799931 (857G>A). majority of studies investigate genotype assay for three SNPs: 481C>T, 590G>A 857G>A. A tag-SNP (rs1495741) recently identified a...
N-Acetyltransferase 2 (NAT2) catalyses the activation and/or deactivation of a variety aromatic amine drugs and carcinogens. Polymorphisms in N-acetyltransferase gene have been associated with drug-induced toxicities, as well cancer various tissues. Eleven single nucleotide polymorphisms (SNPs) identified NAT2 coding region, but specific effects each these SNPs on expression protein enzymatic activity are poorly understood. To investigate functional consequences reference NAT2*4 variant...
Human N-acetyltransferase 2 (NAT2) is polymorphic in humans and may associate with cancer risk by modifying individual susceptibility to cancers from carcinogen exposure. Since molecular epidemiological studies investigating these associations usually include determining NAT2 single-nucleotide polymorphisms (SNPs), haplotypes or genotypes, their conclusions can be compromised the uncertainty of genotype–phenotype relationships. We characterized SNPs cloning expressing recombinant allozymes...