A5101918651- Diabetes Management and Research
- Diabetes and associated disorders
- RNA modifications and cancer
- Cancer-related molecular mechanisms research
- Pancreatic function and diabetes
- Circular RNAs in diseases
- Endoplasmic Reticulum Stress and Disease
- Peripheral Nerve Disorders
- Renal Diseases and Glomerulopathies
- Diabetes Treatment and Management
- RNA Research and Splicing
- Nerve Injury and Rehabilitation
- MicroRNA in disease regulation
- Autophagy in Disease and Therapy
- Pancreatitis Pathology and Treatment
- Nerve injury and regeneration
- Peripheral Artery Disease Management
- Autoimmune Bullous Skin Diseases
- Moyamoya disease diagnosis and treatment
- Liver Disease Diagnosis and Treatment
- Medical Research and Treatments
- Cerebrovascular and Carotid Artery Diseases
- Ferroptosis and cancer prognosis
- Mast cells and histamine
- Metabolism, Diabetes, and Cancer
Fudan University
2004-2024
Huashan Hospital
2000-2024
State Key Laboratory For Conservation and Utilization of Subtropical Agro-Bioresources
2023-2024
Huazhong University of Science and Technology
2023-2024
Wuxi No.2 People's Hospital
2023-2024
Jiangnan University
2024
State Key Laboratory of Biotherapy
2023-2024
Guangxi University
2014-2024
Sichuan University
2023-2024
West China Second University Hospital of Sichuan University
2023-2024
Background Neutrophil/high-density lipoprotein (HDL) ratio (NHR), monocyte/HDL (MHR), lymphocyte/HDL (LHR), platelet/HDL (PHR), systemic immune-inflammation index (SII), system inflammation response (SIRI), and aggregate of (AISI) have been recently investigated as novel inflammatory markers. Herein, the correlation was between these biomarkers peripheral arterial disease (PAD) in type 2 diabetes mellitus (T2DM) patients. Methods In this retrospective observational study, hematological...
From 1986 to 1994, 82 patients with brachial plexus root avulsion were operated on using a contralateral C7 nerve-root transfer. Forty-four underwent one-stage procedure in which the distal end of ulnar nerve was anastomosed root, and other 38 two-stage (first phase: --> nerve; second recipient nerve). Twenty postoperative cases followed-up for 2 years. Of them, transferred musculocutaneous six cases, recovery biceps up M3 four S3 five cases; median eight wrist finger flexors radial triceps...
Hepatitis B virus (HBV) is one of predisposing factors for hepatocellular carcinoma (HCC). The role HBV x protein (HBx) in mediating the induction and maintenance cancer stemness during HBV-related HCC attracts considerable attention, but exact mechanism has not been clearly elucidated. Here, ABCG2-dependent stem-like side population cells, which are thought to be liver stem cells (LCSCs), were present fraction this subset was increased HBx-expressing cells. In addition, glycolysis...
Ultra-small superparamagnetic iron oxide nanoparticles (USPIO-NPs) are widely used as clinical magnetic resonance imaging contrast agents for hepatic diseases diagnosis. USPIO-NPs often damage the hepatocytes and affect function of liver but its mechanism action remains unclear. In present study, caused higher cytotoxicity lactate dehydrogenase (LDH) leakage in L02 cells than SPIO-NPs. Subsequently, affected more genes' expression SPIO-NPs analyzed through microarray bioinformatics analysis....
Abstract Exosomes are considered a mediator of communication within the tumor microenvironment (TME), which modulates cancer progression through transmitting cargos between cells and other cancer-related in TME. Circular RNAs (circRNAs) have emerged to be regulators colorectal (CRC) progression, but most them not been discussed CRC. This study aims investigate role circRNA aspartate beta-hydroxylase (circASPH) CRC its correlation with exosome-mediated At first, we determined that circASPH...
Abstract Based on an anatomic study, a transfer of the brachialis muscle branch musculocutaneous nerve (BMBMCN) to finger flexor functional fascicles median was designed. Preliminary results clinical application this new procedure are reported. Dissection 32 cadaver upper limbs revealed that BMBMCN derives from at distal 1/3 arm level. Mostly it is single‐branch type, with average dissectable length 5.2 cm. At level, flexors located posterior nerve. can be directly coapted these flexion...
Abstract Hepatitis B virus X (HBx) protein contributes to the progression of hepatitis (HBV)-related hepatic injury and diseases, but exact mechanism remains unclear. Protein phosphatase 2 A (PP2A) is a major serine/threonine involved in regulating many cellular phosphorylation signals that are important for regulation cell cycle apoptosis. Does HBx target PP2A-B56γ therefore affect HBx-induced hepatotoxicity? In present study, expression B56γ positively correlated with level HBV-infected...
Mitochondria-associated endoplasmic reticulum (ER) membranes (MAMs) are central microdomains of the ER that interact with mitochondria. MAMs provide an essential platform for crosstalk between and mitochondria play a critical role in local transfer calcium (Ca2+) to maintain cellular functions. Despite potential uses superparamagnetic iron oxide nanoparticles (SPIO-NPs) biomedical applications, hepatotoxicity these (NPs) is not well characterized little known about involvement...
RNF213 gene mutations are the cause behind Moyamoya disease, a rare cerebrovascular occlusive disease. However, function of in vascular system and impact its loss not yet comprehended. To understand RNF23 function, we performed knockdown (KD) cells various phenotypical analysis as well extensive transcriptome epitranscriptome profiling. Our data revealed that KD led to disrupted angiogenesis HUVEC, part due downregulation DNA replication proliferation pathways. Furthermore, HUVEC became...
Abstract Cattle and the draught force provided by its skeletal muscle have been integral to agro‐ecosystems of agricultural civilization for millennia. However, relatively little is known about cattle functional genomics (including protein coding genes, non‐coding RNA, etc.). Circular RNAs (circRNAs), as a new class RNAs, can be effectively translated into detectable peptides, which enlightened us on importance circRNAs in physiology function. Here, RNA‐seq, Ribosome profiling (Ribo‐seq),...
Glycemic variability (GV) in some patients with type 1 diabetes (T1D) remains heterogeneous despite comparable clinical indicators, and whether other factors are involved is yet unknown. Metabolites the serum indicate a broad effect of GV on cellular metabolism therefore more likely to metabolic dysregulation associated T1D. To compare metabolomic profiles between high (GV-H, coefficient variation (CV) glucose ≥ 36%) low (GV-L, CV < groups identify potential biomarkers, metabolomics...
Remnant cholesterol (RC) has been correlated with a higher risk of atherosclerosis. It confirmed that in the general population, an elevated RC level is related to 5-fold peripheral arterial disease (PAD). Diabetes one strongest factors for PAD development. However, association between and specific population type 2 diabetes mellitus (T2DM) not investigated. Herein, correlation was investigated T2DM patients.In retrospective study, hematological parameter data 246 patients without (T2DM -...
Controversy persists regarding the effects of sodium-glucose cotransporter 2 (SGLT2) inhibitors on cancer. The underlying causal relationship remains unclear.
Hyperplasia of the PTG underlies secondary hyperparathyroidism (SHPT) observed in CKD, but mechanism underlying this hyperplasia is incompletely understood. Because aberrant cyclooxygenase 2 (COX2) expression promotes epithelial cell proliferation, we examined effects COX2 on parathyroid gland uremia. In patients with ESRD who underwent parathyroidectomy, clusters cells within glands had increased expression. Some COX2-positive exhibited two nuclei, consistent proliferation. Furthermore,...
JBJS Journal Case Connector Reviews JBJS.org Surgical Techniques Open Access JOPA
Abstract Objective Multiple palmoplantar warts, caused by human papillomavirus (HPV) infection, were investigated for clinical efficacy using cantharidin, retinoic acid cream, and salicylic cream. Methods A total of 110 patients with multiple warts enrolled. The experimental group (54 cases) received a 1:1:1 combination (CRS) 0.25% 0.1% 5% acid, applied pressurized encapsulation 8 h every night, three times per week. control (56 underwent conventional liquid nitrogen freezing. Monthly...
Background There have been some shifts in the frequency and distribution of biopsy-proven renal diseases China over recent years. The aim study was to investigate changing spectrum from view kidney biopsy data a single center China.
Lung metastasis of breast cancer is closely associated with patient morbidity and mortality, which correlates myeloid cells in the lung microenvironment. However, heterogeneity specificity metastasis-associated have not been fully established metastasis. Here, by integrating analyzing single-cell transcriptomics, we found that subpopulations (Tppp3+ monocytes, Isg15+ macrophages, Ifit3+ neutrophils, Il12b+ DCs) play critical roles formation development metastatic niche. Gene enrichment...