A5034298716- Chronic Kidney Disease and Diabetes
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Potassium and Related Disorders
- Renal Diseases and Glomerulopathies
- Caveolin-1 and cellular processes
- NF-κB Signaling Pathways
- Inflammatory mediators and NSAID effects
- Parathyroid Disorders and Treatments
- Drug-Induced Hepatotoxicity and Protection
Wuxi No.2 People's Hospital
2022
Nanjing Medical University
2016-2022
Pediatric Nephrology of Alabama
2011
Fudan University
2009
Hyperplasia of the PTG underlies secondary hyperparathyroidism (SHPT) observed in CKD, but mechanism underlying this hyperplasia is incompletely understood. Because aberrant cyclooxygenase 2 (COX2) expression promotes epithelial cell proliferation, we examined effects COX2 on parathyroid gland uremia. In patients with ESRD who underwent parathyroidectomy, clusters cells within glands had increased expression. Some COX2-positive exhibited two nuclei, consistent proliferation. Furthermore,...
The dysfunction of renal mesangial cells (MCs) is a hallmark diabetic kidney disease (DKD), which triggers glomerulosclerosis leading to end‑stage disease. Procyanidin B2 (PB2), the main component proanthocyanidin, well known for its antioxidant and anti‑inflammatory effects; however, it remains unclear as whether has protective effects on DKD. present study investigated effect PB2 against hyperglycemia‑induced MC in mouse SV40‑Mes13 (Mes13) cells. Mes13 were treated with or without under HG...
The pathogenesis of progressive nephropathies involves inflammatory factors. inhibition cyclooxygenase-2 (COX-2) can limit renal damage and inflammation. However, the mechanism up-regulation COX-2 in nephropathy is poorly defined.Here we found that tumor necrosis factor alpha (TNFα) was involved expression normal rat kidney (NRK) cell line.TNFα stimulated production a time-dependent manner NRK cells by inducing nuclear accumulation RelB kappa B2 (NF-κB2) their association with gene promoter....