A5100687711- Diabetes Treatment and Management
- Metabolism, Diabetes, and Cancer
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diabetes Management and Research
- Diabetes Management and Education
- Diet, Metabolism, and Disease
- Liver Disease Diagnosis and Treatment
- Thyroid Disorders and Treatments
- Hormonal Regulation and Hypertension
- Cancer, Hypoxia, and Metabolism
- Growth Hormone and Insulin-like Growth Factors
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Pharmacological Effects of Natural Compounds
- Pharmacy and Medical Practices
- Stress Responses and Cortisol
- Ovarian function and disorders
- Ginseng Biological Effects and Applications
- Allergic Rhinitis and Sensitization
- Eicosanoids and Hypertension Pharmacology
- Pharmacology and Obesity Treatment
- Inflammatory mediators and NSAID effects
- Neonatal and fetal brain pathology
- Adipose Tissue and Metabolism
- Neurological Disease Mechanisms and Treatments
- Contact Dermatitis and Allergies
Zhejiang Chinese Medical University
2023
Chinese PLA General Hospital
2021-2022
Hainan Medical University
2021
First Affiliated Hospital of Henan University of Science and Technology
2021
Gansu Provincial Hospital
2013-2019
Meizhou City People's Hospital
2019
Ionis Pharmaceuticals (United States)
2016
Dartmouth College
2016
Columbia University
2012-2016
Peking University
2014
Abstract Background The role of apolipoprotein E gene (APOE) in lipid metabolism has been well established, and APOE is associated with the risk cardiovascular disease (CVD) diabetes mellitus (DM). However, relationship between polymorphisms type 2 (T2DM) or without CVD remains unclear. Methods In this cross-sectional study, a total 924 participants including 211 controls (CVD-T2DM-), 247 T2DM patients (CVD-T2DM+), 232 (CVD + T2DM-) 234 T2DM+), were genotyped using chip platform. association...
Introduction: Chronic social isolation (CSI) stress leads to numerous maladaptive changes in physiology and psychology, however, very little is known about the effects of longer time-scale CSI there are divergent views regarding underlying mechanisms. This study aimed elucidate common neuroendocrine mechanisms caused by 14-week (14wk-) 20-week (20wk-) CSI. Methods: We investigated impacts 14wk- 20wk- on anxiety/depression-like behaviors male C57BL/6N mice with classical behavioral tests,...
Type 2 diabetes [T2D] and thyroid dysfunction [TD] often co-occur, have overlapping pathologies, their risk increases with age. Since 1995, universal salt iodization has been implemented in China to prevent disorders caused by iodine deficiency. However, after two decades of implementation iodization, the prevalence TD elderly Chinese patients T2D is not well described may underestimated. We conducted a questionnaire-based survey across 24 endocrinology centers between December 2015 July...
Background The association between the triglyceride–glucose (TyG) index and type 2 diabetes mellitus (T2DM) in older adults has not been fully understood. This research aims to explore TyG incidence of T2DM an Chinese population aged over 75 years. Methods longitudinal analysis study was performed based on a database from health check screening program China. participants were stratified quintile ranges (Q1 Q5 groups). defined as fasting plasma glucose (FPG) ≥ 7.00 mmol/L and/or...
Plasma levels of high-density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (ApoA-I) are reduced in individuals with defective insulin signaling. Initial studies using liver-specific receptor (InsR) knockout mice identified expression type 1 deiodinase (Dio1) as a potentially novel link between hepatic signaling the ApoA-I gene. Our objective was to examine regulation by Dio1.Acute inactivation InsR adenoviral delivery Cre recombinase floxed HDL-C both Dio1. Overexpression Dio1...
This study, a subgroup analysis of the data from Organization Program DiabEtes INsulIN ManaGement aimed to compare efficacy and safety profiles acarbose metformin used in combination with premixed insulin.This included 80 192 patients taking only 1 oral antidiabetic drug, classified into (treated + insulin) groups insulin), respectively. The were analyzed for within- between-group differences. clinical trial registry number was NCT01338376.The percentage who achieved target hemoglobin A1c...
This study aimed to investigate the application value of "time in ranges (TIRs)" dialysis patients with diabetes and summarize experience optimizing glycemic control by flash glucose monitoring (FGM) system.In this monocentric 2-week pilot study, FGM was applied for 14 days 57 type 2 mellitus medically stable under maintenance hemodialysis determine their improvement. The diagnostic TIR versus HbA1c detecting fluctuations levels evaluated using receiver operating characteristic...
Objective To assess current treatment and glycaemic control of adult subjects with type 2 diabetes mellitus (T2DM) in China, focusing on the therapy oral anti-diabetic drugs (OAD) combination insulin. Methods From July to September 2009, 400 hospitals from 75 cities across China were selected by Chinese Diabetes Society for this cross-sectional study. All T2DM patients (over 18 years) antidiabetic drug with/without insulin eligible General information patients, duration diabetes,...
Objective: To estimate patient preferences for second-line antihyperglycemic medications in China. Methods: A face to survey with the best-worst scaling (BWS) choices was administered patients diagnosed type 2 diabetes mellitus (T2DM). Study participants were asked indicate which attribute they valued most and least 11 choice sets, each of consisted five alternatives out medication-specific attributes (treatment efficacy, weight change, hypoglycemic events, gastrointestinal side effects,...
Established rat models with subclinical hypothyroidism(SCH)were divided into three groups: hypothyroid(SCH), SCH treated levothyroxine(L-T4), and control group. The L-T4 group displayed lowered total cholesterol endothelin levels compared the group[(1.29±0.05 vs 2.38±0.55)mmol/L, (98.54±32.43 160.62±37.25)nmol/L, both P<0.05]. Nitric oxide levels, left ventricular systolic pressure, blood flow in abdominal aorta were significantly higher than those results of this study indicate that...
Objective To analysis the characteristics and distribution of impaired glucose regulation (IGR) in Gansu province. Methods We selected 28 087 participants who were 20-74 years old diabetes epidemiology survey between 2013 2014 province which enrolled 31 417 then divided them into 4 groups by blood level after 75 g oral tolerance test (OGTT) according to 1999 WHO diagnostic criteria: normal (NGT), isolated fasting (I-IFG) (I-IGT) groups, combined IFG IGT (IFG/IGT) groups. Then we...
Objective To evaluate the sensitivity to fragrance mixture,colophony and Qingpeng ointment in patients with eczema by a patch test,and assess relationship between test reactions mixture or colophony those ointment,so as determine if clinically reactive can apply safely.Methods Patch testing was carried out European standard series raw materials of outpatients dermatitis.The clinical relevance results analyzed based on medical history follow-up study.Data were processed SPSS 17.0...
Low HDL cholesterol is a common feature of insulin resistant states such as type 2 diabetes, but little known about the regulation and apoAI levels by signaling. In prior studies, we observed that liver receptor (Insr) knockout mice (LIRKO) had very low plasma compared with their controls. were normalized when restored signaling expression constitutively active (CA) AKT1. Acute knock down hepatic Insr adenovirus-mediated albumin-Cre in flox/flox resulted marked decrease ApoAI Dio1 mRNA...