Yishan Qu

ORCID: 0000-0002-1849-6361
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About
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Research Areas
  • Neuroendocrine regulation and behavior
  • Olfactory and Sensory Function Studies
  • Stress Responses and Cortisol
  • Infant Health and Development
  • Memory and Neural Mechanisms
  • Neuroscience of respiration and sleep
  • Evolutionary Psychology and Human Behavior
  • Neuroscience and Neuropharmacology Research
  • Treatment of Major Depression
  • Biochemical effects in animals
  • Exercise and Physiological Responses
  • Action Observation and Synchronization
  • Pain Management and Placebo Effect
  • Chronic Kidney Disease and Diabetes
  • Neural dynamics and brain function
  • Health and Well-being Studies
  • Tryptophan and brain disorders
  • Neuroscience, Education and Cognitive Function
  • Child and Adolescent Psychosocial and Emotional Development
  • Vestibular and auditory disorders
  • Cancer, Hypoxia, and Metabolism
  • Alcohol Consumption and Health Effects
  • Adipose Tissue and Metabolism

Shaanxi Normal University
2021-2025

The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, involvements of DA release, real time activities, and electrophysiological activities D1/D2 medium spiny neurons (MSNs) the nucleus accumbens (NAc) shell bonding remain unclear. This work verified that male mandarin voles after released higher levels NAc displayed D1 MSNs activity lower D2 upon sniffing their partners compared to an unknown female. Moreover, induced differential alterations both synaptic...

10.7554/elife.100292.2 preprint EN 2025-02-24

Introduction: Chronic social isolation (CSI) stress leads to numerous maladaptive changes in physiology and psychology, however, very little is known about the effects of longer time-scale CSI there are divergent views regarding underlying mechanisms. This study aimed elucidate common neuroendocrine mechanisms caused by 14-week (14wk-) 20-week (20wk-) CSI. Methods: We investigated impacts 14wk- 20wk- on anxiety/depression-like behaviors male C57BL/6N mice with classical behavioral tests,...

10.1159/000544839 article EN Neuroendocrinology 2025-02-25

Many species of animals exhibit caregiving or aggression toward conspecific offspring. The neural mechanisms underlying the infanticide and pup care remain poorly understood. Here, using monogamous mandarin voles ( Microtus mandarinus ), we found that more oxytocin (OT) neurons in paraventricular nucleus (PVN) were activated during caring than infanticide. Optogenetic activation OT PVN facilitated male female voles. In voles, optogenetic cells PVN-medial prefrontal cortex (mPFC) projection...

10.7554/elife.96543 article EN cc-by eLife 2024-04-17

Abstract The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, involvements of DA release, real time activities, and electrophysiological activities D1/D2 medium spiny neurons (MSNs) the nucleus accumbens (NAc) shell bonding remain unclear. This work verified that male mandarin voles after released higher levels NAc displayed D1 MSNs activity lower D2 upon sniffing their partners compared to an unknown female. Moreover, induced differential alterations both...

10.1101/2024.07.24.604911 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2024-07-24

Introduction: Empathy is the ability of an individual to present and respond emotions others thought originate from parental behavior. Testosterone could promote aggression inhibit biparental behavior vasopressin (AVP) aggression. Given levels care are closely associated with empathy, we hypothesized that testosterone may influence empathetic via AVP system. Methods: We examined tested social, empathic, anxiety-like behaviors after castration surgery pubertal mice, subsequently molecular...

10.1159/000540938 article EN Neuroendocrinology 2024-08-23

Animals may experience early negative (mechanical pain: being retrieved using an incisor by parents or attacked) positive stimulation (being licked and groomed) that affect emotional social behaviors in adulthood. Whether tactile can reverse adverse consequences on adulthood resulting from chronic mechanical pain underlying mechanisms remain unclear. This study used a tail-pinching model during development to simulate experienced pups high-social mandarin voles (Microtus mandarinus)....

10.1111/1749-4877.12907 article EN cc-by-nc-nd Integrative Zoology 2024-09-23

Male mammals display different paternal responses to pups, either attacking or killing the young offspring, contrastingly, caring for them. The neural circuit mechanism underlying between-individual variation in pup-directed responsiveness of male remains unclear. Monogamous mandarin voles were used complete present study. individuals identified as and infanticidal voles, according their behavioral pups. It was found that serotonin release medial preoptic area (MPOA), well serotonergic...

10.3390/ijms241411605 article EN International Journal of Molecular Sciences 2023-07-18

Abstract In many species, adult animals may exhibit caregiving or aggression towards conspecific offspring. The neural mechanisms underlying the infanticide and pup care remain poorly understood. Here, using monogamous virgin mandarin voles ( Microtus mandarinus ) that infanticide, we found more oxytocin (OT) neurons in paraventricular nucleus (PVN) were activated during caring than infanticide. Optogenetic activation of OT PVN facilitated pup-caring male female voles. voles, optogenetic...

10.1101/2024.03.06.583718 preprint EN cc-by bioRxiv (Cold Spring Harbor Laboratory) 2024-03-11

In many species, adult animals may exhibit caregiving or aggression towards conspecific offspring. The neural mechanisms underlying the infanticide and pup care remain poorly understood. Here, using monogamous virgin mandarin voles ( Microtus mandarinus ) that infanticide, we found more oxytocin (OT) neurons in paraventricular nucleus (PVN) were activated during caring than infanticide. Optogenetic activation of OT PVN facilitated pup-caring male female voles. voles, optogenetic cells...

10.7554/elife.96543.1 preprint EN 2024-04-17

In many species, adult animals may exhibit caregiving or aggression towards conspecific offspring. The neural mechanisms underlying the infanticide and pup care remain poorly understood. Here, using monogamous virgin mandarin voles ( Microtus mandarinus ) that infanticide, we found more oxytocin (OT) neurons in paraventricular nucleus (PVN) were activated during caring than infanticide. Optogenetic activation of OT PVN facilitated pup-caring male female voles. voles, optogenetic cells...

10.7554/elife.96543.2 preprint EN 2024-09-10

The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, involvements of DA release, real time activities, and electrophysiological activities D1/D2 medium spiny neurons (MSNs) the nucleus accumbens (NAc) shell bonding remain unclear. This work verified that male mandarin voles after released higher levels NAc displayed D1 MSNs activity lower D2 upon sniffing their partners compared to an unknown female. Moreover, induced differential alterations both synaptic...

10.7554/elife.100292 preprint EN 2024-10-11

The mesolimbic dopamine (DA) system has been implicated in pair bond formation. However, involvements of DA release, real time activities, and electrophysiological activities D1/D2 medium spiny neurons (MSNs) the nucleus accumbens (NAc) shell bonding remain unclear. This work verified that male mandarin voles after released higher levels NAc displayed D1 MSNs activity lower D2 upon sniffing their partners compared to an unknown female. Moreover, induced differential alterations both synaptic...

10.7554/elife.100292.1 preprint EN 2024-10-11

Many species of animals exhibit caregiving or aggression toward conspecific offspring. The neural mechanisms underlying the infanticide and pup care remain poorly understood. Here, using monogamous mandarin voles ( Microtus mandarinus ), we found that more oxytocin (OT) neurons in paraventricular nucleus (PVN) were activated during caring than infanticide. Optogenetic activation OT PVN facilitated male female voles. In voles, optogenetic cells PVN-medial prefrontal cortex (mPFC) projection...

10.7554/elife.96543.3 article EN cc-by eLife 2024-10-16
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