A5101211019- Colorectal Cancer Treatments and Studies
- Ubiquitin and proteasome pathways
- Cancer Mechanisms and Therapy
- Cancer, Lipids, and Metabolism
- Cancer-related Molecular Pathways
- Cancer Genomics and Diagnostics
- Metabolomics and Mass Spectrometry Studies
- Cancer Cells and Metastasis
- Intensive Care Unit Cognitive Disorders
- Colorectal Cancer Screening and Detection
- Biomedical and Chemical Research
- Genetic factors in colorectal cancer
- Electrolyte and hormonal disorders
- Pancreatic and Hepatic Oncology Research
Chongqing University
2024
Hebei University of Engineering
2024
Jiangsu Cancer Hospital
2024
Nanjing Medical University
2024
Ruijin Hospital
2023
Shanghai Jiao Tong University
2023
Abstract Colorectal cancer is frequently diagnosed in advanced stages, highlighting the need for developing approaches early detection. Liquid biopsy using cell-free DNA (cfDNA) fragmentomics a promising approach, but clinical application hindered by complexity and cost. This study aimed to develop an integrated model cfDNA accurate, cost-effective early-stage colorectal Plasma was extracted sequenced from training cohort of 360 participants, including 176 patients with 184 healthy controls....
<title>Abstract</title> Chaperonin-containing TCP-1 (CCT) is a complex of proteins essential for cancer progression. CCT6A, the ζ subunit CCT, contributes to tumorigenesis in various human cancers, but its function remains unclear. CCT6A had significantly higher expression colon than other CCT subunits, was upregulated cells and clinical samples, correlated with an unfavorable prognosis among colon-cancer patients. GSEA results suggested that plays role cellular-process signaling pathways,...
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<div>Abstract<p>Colorectal cancer is frequently diagnosed in advanced stages, highlighting the need for developing approaches early detection. Liquid biopsy using cell-free DNA (cfDNA) fragmentomics a promising approach, but clinical application hindered by complexity and cost. This study aimed to develop an integrated model cfDNA accurate, cost-effective early-stage colorectal Plasma was extracted sequenced from training cohort of 360 participants, including 176 patients with...
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<h3>Background</h3> Advanced pancreatic ductal adenocarcinoma (PDAC) relies on systematic chemotherapy, while the response rate is low. The relationship between tumor microenvironment (TME) remodeling and treatment still unclear. We aimed to reveal dynamic changes of TME during chemotherapy identify key regulators in chemoresistance by combining endoscopic ultrasound-guided fine needle biopsy (EUS-FNB) with single-cell RNA sequencing (scRNA-seq). <h3>Methods</h3> performed scRNA-seq pre-and...