A5081910976- Engineering Structural Analysis Methods
- Structural Integrity and Reliability Analysis
- Structural Load-Bearing Analysis
- Mechanical stress and fatigue analysis
- Advanced MEMS and NEMS Technologies
- Cell Adhesion Molecules Research
- Acoustic Wave Resonator Technologies
- Mechanical and Optical Resonators
- Composite Structure Analysis and Optimization
- Mechanical Behavior of Composites
- Vibration and Dynamic Analysis
- Fatigue and fracture mechanics
- High-Velocity Impact and Material Behavior
- Orbital Angular Momentum in Optics
- Caveolin-1 and cellular processes
- Near-Field Optical Microscopy
- Microfluidic and Bio-sensing Technologies
- Fluid Dynamics Simulations and Interactions
- Optical measurement and interference techniques
- Cellular and Composite Structures
- Numerical methods in engineering
- Marine and Offshore Engineering Studies
- Geotechnical Engineering and Underground Structures
- Spacecraft and Cryogenic Technologies
- Mechanical Failure Analysis and Simulation
Tilburg University
2024
Agency for Science, Technology and Research
2022-2024
Genome Institute of Singapore
2022-2024
University of Michigan
2022
Nanyang Technological University
2006-2021
Relapse to anti-HER2 monoclonal antibody (mAb) therapies, such as trastuzumab in HER2+ breast cancer (BC), is associated with residual disease progression due resistance therapy. Here, we identify interferon-γ inducible protein 16 (IFI16)-dependent STING signaling a significant determinant of responses BC. We show that down-regulation immune-regulated genes (IRG) specifically poor survival HER2+, but not other BC subtypes. Among IRG, IFI16 identified direct target EZH2, the underexpression...
Abstract The hypoxic tumor microenvironment has been implicated in immune escape, but the underlying mechanism remains elusive. Using an vitro culture system modeling human T cell dysfunction and exhaustion triple-negative breast cancer (TNBC), we find that hypoxia suppresses effector gene expression, including NK cells, resulting resistance to immunotherapy. We demonstrate hypoxia-induced factor 1α (HIF1α) interaction with HDAC1 concurrent PRC2 dependency causes chromatin remolding...
The authors present a power-efficient large-scale lensless optical traps on chip (OTOCs) as an optofluidic element for sorting of microparticles. Based the well-known Talbot self-imaging effect in Fresnel region, OTOC makes use two-dimensional microfabricated chessboardlike structure to create lattice near its emergent plane. Simultaneous trapping hundreds microparticles regular array (>200×200μm2) is proved experimentally without adopting external projection lens configuration....
Medium damping influences on the resonant frequency and quality factor of piezoelectric circular microdiaphragm sensors (PCMSs) are investigated theoretically experimentally in this paper. The acoustic radiation viscosity as two main sources energy dissipation a medium virtually added mass diaphragm therefore decrease Q-factor diaphragm. magnitude inversely depends radius-to-thickness ratio. An increase ratio is trend fabrication thin microdiaphragms by MEMS processes, which implies higher...
In this study, residual stress influences on the vibrational behavior of piezoelectric circular microdiaphragm-based biosensors are investigated theoretically and experimentally. The microdiaphragm was first fabricated by combining sol–gel PZT thin film MEMS technology. measurements wafer curvature method micro-Raman technique demonstrate that high tensile stresses generated in upper films (Pt/PZT/Pt), while silicon oxide layer experiences a compressive stress. After backside etching...
The vibration modes of a piezoelectric circular microdiaphragm (PCM) are visualized and investigated in this paper. PCM was previously fabricated by combining sol–gel PZT thin film MEMS technology (Olfatnia et al 2010 J. Micromech. Microeng. 20 015007). We used reflection digital holography microscope to visualize different frequency modes. It found that the degeneracy with at least one nodal diameter is broken, even though it expected these orthogonal degenerated (Meirovitch 1967 Analytical...
Abstract Kindlins are FERM-containing cytoplasmic proteins that regulate integrin-mediated cell-cell and cell-extracellular matrix (ECM) attachments. Kindlin-3 is expressed in hematopoietic cells, platelets endothelial cells. Studies have shown kindlin-3 stabilizes cell adhesion mediated by ß1, ß2 ß3 integrins. Apart from integrin tails, kindlins known to interact with other proteins. Here we demonstrate can associate ribosome via the receptor for activated-C kinase 1 (RACK1) scaffold...
The authors propose a three-dimensional (3D) optical trapping of microparticles in multiple planes simultaneously based on modified self-imaging effect. Similar to the Talbot effect, effect is induced by layer trapped particles and it subsequently used as periodic grating structure generate its own pattern 3D. Based this secondary layer-by-layer silica polystyrene colloidal at different microchamber are demonstrated experimentally.
Kindlins are a small family of 4.1-ezrin-radixin-moesin (FERM)-containing cytoplasmic proteins. Kindlin-3 is expressed in platelets, hematopoietic cells, and endothelial cells. promotes integrin activation, clustering outside-in signaling. Aberrant expression kindlin-3 was reported melanoma breast cancer. Intriguingly, has been to either positively or negatively regulate cancer cell metastasis. In this study, we sought clarify the cells its role Two widely used metastatic mouse human lines...
The problem of a local dent on pressurized pipe is studied in this paper. Two case problems are considered - plain (a smooth without surface defect), and associated with loss thickness defect. strain gauging test the finite element analysis showed that distributions different from those long continuous dent. maximum hoop located at flank dent, along axial axis, whereas it root In addition, peak stress generally lower than To estimate concentration using for would be grossly overestimated....
We propose a simple, reliable and cost-effective method for microfluidic sorting of microparticles using an optical potential landscape projected by composite microlens array (MLA). The MLA enables high power efficient approach to forming shape size the pattern. Sorting particles is demonstrated both theoretically experimentally.
Shot-peening induced residual stresses can be relaxed due to cyclic loading. This relaxation plays an important role in determining the fatigue life of peened components. It is therefore purpose this study conduct comprehensive three-dimensional dynamic elasto-plastic finite element analysis joint peening treatment and process. In regard, a novel symmetry cell developed used model multiple impact indentations resulting from impingements cluster shots. The was further extended integrate...
Carbon fiber reinforced polymer composites, especially carbon/epoxy, have been attracting interest from offshore oil and gas industry as alternatives to metals for deepwater risers due their very high performance besides being light weight. Composite risers, however, require an inner liner of metal prevent leakage damage the outer composite layers. The bonding between composites is critical overall integrity riser. In this study, two mechanical surface treatment methods, grit blasting...