A5023743063- Carcinogens and Genotoxicity Assessment
- Toxic Organic Pollutants Impact
- Liver Disease Diagnosis and Treatment
- Effects and risks of endocrine disrupting chemicals
- Genomics, phytochemicals, and oxidative stress
- Glutathione Transferases and Polymorphisms
- Drug-Induced Hepatotoxicity and Protection
- Drug Transport and Resistance Mechanisms
- Connexins and lens biology
- Liver physiology and pathology
- Pharmacogenetics and Drug Metabolism
- Peroxisome Proliferator-Activated Receptors
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Neuroscience and Neuropharmacology Research
- Retinoids in leukemia and cellular processes
- Tea Polyphenols and Effects
- Liver Disease and Transplantation
- Cancer, Stress, Anesthesia, and Immune Response
- Pesticide Exposure and Toxicity
- Photodynamic Therapy Research Studies
- Environmental Toxicology and Ecotoxicology
- Metabolomics and Mass Spectrometry Studies
- Per- and polyfluoroalkyl substances research
- Diet, Metabolism, and Disease
Indiana University
2005-2025
Indiana University Bloomington
2015-2024
Indiana University Health
2006-2019
Indiana University – Purdue University Indianapolis
2005-2014
Indiana University Indianapolis
2007-2013
Indiana University School of Medicine
2003-2012
Center for Environmental Health
2007-2010
Riley Hospital for Children
2008
University of North Carolina at Chapel Hill
2006
Institute of Pharmacology
2006
An antioxidant fraction of Chinese green tea (green antioxidant; GTA), containing several catechins, has been previously shown to inhibit 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced tumor promotion in mouse skin. In the present study, GTA was have antioxidative activity toward hydrogen peroxide (H2O2) and superoxide radical (O2-). also prevented oxygen H2O2-induced cytotoxicity inhibition intercellular communication cultured B6C3F1 hepatocytes human keratinocytes (NHEK cells)....
Hazard identification and risk assessment paradigms depend on the presumption of similarity rodents to humans, yet species specific responses, extrapolation high-dose effects low-dose exposures can affect estimation human from rodent data. As a consequence, relevance framework concept was developed by International Programme Chemical Safety (IPCS) Life Sciences Institute (ILSI) Risk Science (RSI) with central tenet being mode action (MOA). To perform MOA analysis, key biochemical, cellular,...
Abstract Miniature pigs residing in the Ossabaw Island (Ossabaw pigs) exhibit a thrifty genotype, and when fed high-calorie diet they consistently develop metabolic syndrome defined by obesity, insulin resistance, hypertension, dyslipidemia. We conducted study to induce steatohepatitis dietary manipulation. Pigs were standard chow (controls, n = 15), high-fructose (20% kcal from fructose 10.5% fat) (fructose group, 9), atherogenic 46% fat 2% cholesterol 0.7% cholate weight) (atherogenic 13),...
Abstract Single‐cell gel electrophoresis, commonly called a comet assay, is simple and sensitive method for assessing DNA damage at the single‐cell level. It an important technique in genetic toxicological studies. The assay performed under alkaline conditions (pH >13) considered optimal version identifying agents with genotoxic activity. capable of detecting double‐strand breaks, single‐strand alkali‐labile sites, DNA‐DNA/DNA‐protein cross‐linking, incomplete excision repair sites....
Social impairment is a defining feature of autism spectrum disorder (ASD) with no demonstrated effective pharmacologic treatments. The goal this study was to evaluate efficacy, safety, and tolerability oral N-acetylcysteine (NAC), an antioxidant whose function overlaps proposed mechanisms ASD pathophysiology, targeting core social in youth ASD. This 12-week randomized, double-blind, placebo-controlled trial NAC Study participants were medically healthy age 4 12 years ASD, weighing ≥15 kg,...
Abstract Objective —To determine the effect of transportation stress on serum concentrations oxidative biomarkers calves. Animals —105 crossbred beef steer calves (mean [± SD] body weight, 207 ± 21.2 kg). Procedure —Calves were assembled at 1 location in Tennessee, and pretransit (day –3) blood samples collected. Calves allotted randomly by weight into 2 groups. transported 1,930 miles to a feedlot Texas, group received tilmicosin phosphate (33 µg/kg, SC) upon arrival. weighed collected day...
Defining the mode(s) of action by which chemicals induce tumors in laboratory animals has become a key to judgments about relevance such tumor data for human risk assessment. Frameworks analyzing mode information appear recent U.S. EPA and IPCS publications relating cancer This FORUM paper emphasizes that analytical frameworks depend on both qualitative quantitative evaluations relevant information: (1) presenting events animal action, (2) developing “concordance” table side-by-side...