A5066129595- Prostate Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Bladder and Urothelial Cancer Treatments
- Global Cancer Incidence and Screening
- Health Systems, Economic Evaluations, Quality of Life
- Renal cell carcinoma treatment
- Urinary Bladder and Prostate Research
- Genital Health and Disease
- Patient-Provider Communication in Healthcare
- Testicular diseases and treatments
- Economic and Financial Impacts of Cancer
- Advances in Oncology and Radiotherapy
- Pelvic floor disorders treatments
- Palliative Care and End-of-Life Issues
- Cancer survivorship and care
- Colorectal Cancer Screening and Detection
- Advanced Radiotherapy Techniques
- Urologic and reproductive health conditions
- Radiation Dose and Imaging
- Sexual function and dysfunction studies
- COVID-19 and healthcare impacts
- Childhood Cancer Survivors' Quality of Life
- Patient Satisfaction in Healthcare
- Urinary Tract Infections Management
- Behavioral Health and Interventions
Royal Marsden NHS Foundation Trust
2016-2025
Royal Marsden Hospital
2017-2025
King's College London
2017-2024
Epsom and St Helier University Hospitals NHS Trust
2022
Mater Misericordiae University Hospital
2021
Frimley Health NHS Foundation Trust
2021
Guy's Hospital
2013-2019
London Cancer
2019
University of South Australia
2018
Guy's and St Thomas' NHS Foundation Trust
2010-2016
Active surveillance (AS) is recommended for low-risk and some intermediate-risk prostate cancer. Uptake practice of AS vary significantly across different settings, as does the experience surveillance-from which tests are offered, to levels psychological support.To explore current best determine most important research priorities in cancer.A formal consensus process was followed, with an international expert panel purposively sampled participants a range health care professionals...
To describe a protocol for transperineal sector biopsies (TPSB) of the prostate and present clinical experience this technique in UK population.A retrospective review single-centre TPSB approach was undertaken that preferentially, but not exclusively, targeted peripheral zone with 24-38 cores using 'sector plan'. Procedures were carried out under general anaesthetic most patients. Between January 2007 August 2011, 634 consecutive patients underwent following indications: prior negative...
Objective To explore patients’ experience of decision making regarding treatment localised kidney cancer. Methods A total 21 patients with cancer, across three countries, participated in either four focus groups or seven semi‐structured interviews that lasted on average 2 h. Focus and were all conducted the participants' native language, recorded, transcribed (if applicable) translated into English. Thematic analysis was used to develop a codebook identify themes. Results All participants...
317 Background: Early intervention is potentially lifesaving in prostate cancer and a major limitation of outcomes with ethnicity deprivation being determinants inequalities that impact outcomes. The Man Van designed to address health barriers accessing healthcare affect novel community-based targeting high-risk groups using mobile clinical unit. These are particularly relevant for men from ethnic minorities lower socio-economic groups. Methods: A bespoke nurse-led unit was moved locations...
ABSTRACT Background Prostate specific antigen density (PSAd) is one of the strongest predictors clinically‐significant prostate cancer (csPCa) in risk calculators. There little evidence on effect volume diagnostic performance PSAd. Our aim was to define accuracy PSAd for predicting csPCa across volumes. Methods 548 patients who underwent magnetic resonance imaging (MRI) and biopsy were included this retrospective study. Patients grouped by volume; small (≤ 30 mL), medium (> < 50 large...
10500 Background: Incidence of prostate cancer (PCa) is increasing, but there no internationally agreed population screening program. Studies using an age-based PSA approach show a high rate false-positive results as well over-diagnosis indolent PCa. Genome wide association studies identify common germline variants to calculate polygenic risk score (PRS) associated with PCa risk. The BARCODE1 study used PRS target those at higher based on genotype. Methods: European men aged 55-69yrs were...
Active surveillance (AS) is recommended by most national medical organizations as the preferred treatment option for men with low-risk prostate cancer (PCa). However, studies report that up to one third of on AS dropout within 5 years, without evidence disease progression. Despite high rates, few have purposively explored opinions and experiences who discontinued AS. The aim this study was gain insight into reasons why some PCa discontinue active progression.Semi-structured interviews were...
Aim . To explore patient experiences of a structured exercise intervention for men with prostate cancer (PCa). Sample 41 either localised or advanced PCa who had been referred programme by their physician and then subsequently consented to telephone survey. Method Participants underwent 10-week supervised within large centre hospital consisting 8 sessions. They completed short multiple choice survey, elaborating on responses where appropriate. Views expressed participants were analysed using...
Abstract Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution PSA) associated reduced risk, however, functional relevance unknown. Here, we identify that SNP variant-induced change PSA biochemical activity mediates pathogenesis. ‘Thr’ variant leads to small subcutaneous tumours, supporting risk. However, also displays higher metastatic...
To determine whether preoperative demonstrations of intracavernosal and vacuum therapies for erectile dysfunction (ED) influence the decision treatment choice, reducing long-term regret.In all, 82 consecutive men with localized prostate cancer, scheduled radical prostatectomy reporting an International Index Erectile Function score >21, were prospectively enrolled at a single cancer centre. Following standard counselling, half invited to attend further consultation therapy demonstrations....
We wanted to determine whether serial transperineal sector prostate biopsies have a long-term effect on erectile dysfunction (ED).A total of 64 men with cancer entered our active surveillance (AS) programme after transrectal biopsy as well confirmatory initial (TPSBx).A repeat TPSBx was performed 24 months later part protocol.The International Index Erectile Function-5 (IIEF-5) questionnaire assessed ED at baseline prior each TPSBx, and one, three, six first second TPSBx.There significant...
Objectives: To evaluate how accurate a 12-core transrectal biopsy derived low-risk prostate cancer diagnosis is for an active surveillance programme by comparing the histological outcome with that from confirmatory transperineal sector biopsy. Subjects and methods:The cohort included 166 men diagnosed low volume Gleason score 3+3 on initial who also underwent biopsy.Both techniques were performed according to standard protocols samples taken histopathology analysis.Subgroup analysis was...
6522 Background: Early intervention is potentially lifesaving in prostate cancer. The debate for screening continues with recent developments suggesting the arguments favour are becoming stronger however, barriers to access remain. Man Van project designed address these a highly novel community-based targeting of high-risk groups on mobile unit. Methods: A bespoke health vehicle was moved 8 locations areas high deprivation indices London, UK, inviting men check consisting of: general...