Leire Moya
A5014207510- Prostate Cancer Treatment and Research
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Genetic Associations and Epidemiology
- MicroRNA in disease regulation
- RNA modifications and cancer
- SARS-CoV-2 and COVID-19 Research
- Molecular Biology Techniques and Applications
- Prostate Cancer Diagnosis and Treatment
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Circular RNAs in diseases
- Management of metastatic bone disease
- Liver Disease Diagnosis and Treatment
- Cancer-related gene regulation
- COVID-19 Clinical Research Studies
- Legume Nitrogen Fixing Symbiosis
- Radiopharmaceutical Chemistry and Applications
- Food composition and properties
- RNA regulation and disease
- Immune responses and vaccinations
- Genomics and Chromatin Dynamics
- Cancer Cells and Metastasis
- Hypothalamic control of reproductive hormones
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Garlic and Onion Studies
Queensland University of Technology
2015-2024
Translational Research Institute
2015-2022
Prostate Cancer Research
2014-2018
Plant & Food Research
2013-2017
QIMR Berghofer Medical Research Institute
2015
Universitat Politècnica de València
2013
Hospital Plató
1990-2013
Prostate cancer is diagnosed in over 1 million men every year globally, yet current diagnostic modalities are inadequate for identification of significant and more reliable early biomarkers necessary improved clinical management prostate patients. MicroRNAs (miRNAs) modulate important cellular processes/pathways contributing to stably present body fluids. In this study we profiled 372 cancer-associated miRNAs plasma collected before (~60% patients) after/during commencement treatment (~40%...
Abstract The timing of puberty is highly variable and associated with long-term health outcomes. To date, understanding the genetic control based largely on studies in women. Here, we report a multi-trait genome-wide association study for male an effective sample size 205,354 men. We find moderately strong genomic correlation between sexes (rg = 0.68) identify 76 independent signals timing. Implicated mechanisms include unexpected link natural hair colour, possibly reflecting common effects...
Abstract Background Prostate cancer is a broad-spectrum disease, spanning from indolent to highly aggressive lethal malignancy. cell lines are essential tools understanding the basic features of this malignancy, as well in identifying novel therapeutic strategies. However, most routinely used prostate research derived metastatic disease and may not fully elucidate molecular events underlying early stages development progression. Thus, there need for new localised better span spectrum....
The oncogene MDM4 , also known as MDMX or HDMX contributes to cancer susceptibility and progression through its capacity negatively regulate a range of genes with tumour-suppressive functions. As part recent genome-wide association study it was determined that the A-allele rs4245739 SNP (A>C), located in 3′-UTR is associated an increased risk prostate cancer. Computational predictions revealed within predicted binding site for three microRNAs (miRNAs): miR-191-5p, miR-887 miR-3669....
Common variants in the hepatocyte nuclear factor 1 homeobox B (HNF1B) gene are associated with risk of Type II diabetes and multiple cancers. Evidence to date indicates that cancer may be mediated via genetic or epigenetic effects on HNF1B expression. We previously found single-nucleotide polymorphisms (SNPs) at locus endometrial cancer, now report extensive fine-mapping silico laboratory analyses this locus. Analysis 1184 genotyped imputed SNPs 6608 Caucasian cases 37 925 controls, 895...
Abstract Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the region from 71,535 cancer cases and 52,935 controls of European ancestry to define overall contribution germline variation at risk. We identify 12 independent risk signals ( p < 4.28 × 10 −15 ), three variants that have yet be reported. From polygenic score (PRS) model, derived assess cumulative effect 8q24, men in top 1% PRS 4-fold (95%CI =...
Although starch consists of large macromolecules composed glucose units linked by α-1,4-glycosidic linkages with α-1,6-glycosidic branchpoints, variation in structural and functional properties is found both within between species. Interest genetics based on the importance food industrial processes, potential to provide novel starches. The metabolic pathway complex but has been characterized diverse plant species, including pea. To understand how allelic pea affects structure percent...
Abstract Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution PSA) associated reduced risk, however, functional relevance unknown. Here, we identify that SNP variant-induced change PSA biochemical activity mediates pathogenesis. ‘Thr’ variant leads to small subcutaneous tumours, supporting risk. However, also displays higher metastatic...
Fusion transcripts are found in many tissues and have the potential to create novel functional products. Here, we investigate genomic sequences around fusion junctions better understand transcriptional mechanisms mediating transcription/splicing. We analyzed data from prostate (cancer) cells as previous studies shown extensively that these readily undergo transcription.We used FusionMap program identify high-confidence RNAseq data. The datasets were our (N = 8) other 14) clinical tumors with...
Short tandem repeats (STRs) are repetitive sequences of a polymorphic stretch two to six nucleotides. We hypothesized that STRs associated with prostate cancer development and/or progression. undertook RNA sequencing analysis tumors and adjacent non-malignant cells identify readily expressed in these cells. Most the clinical samples mapped intronic intergenic DNA. Our indicated three (TAAA-ACTG2, TTTTG-TRIB1, TG-PCA3) differentially compared TG-PCA3 STR expression was repressed by...
With an estimated 1.1 million men worldwide diagnosed with prostate cancer yearly, effective and more specific biomarkers for early diagnosis could lead to better treatments. As such, novel genetic markers are sought this purpose. The tribbles homologue 1 gene (TRIB1) has recently shown have a role in tumorigenesis oncomine data-mining confirmed clinical significance of TRIB1 cancer. For the first time, polymorphic microsatellite been studied its potential association risk aggressiveness....