A5041589702- Assisted Reproductive Technology and Twin Pregnancy
- Birth, Development, and Health
- Genetic and Environmental Crop Studies
- Neonatal Respiratory Health Research
- Infant Development and Preterm Care
- Legume Nitrogen Fixing Symbiosis
- Preterm Birth and Chorioamnionitis
- Sarcoma Diagnosis and Treatment
- Plant Disease Resistance and Genetics
- Child and Adolescent Health
- Food composition and properties
- Agricultural pest management studies
- Gestational Diabetes Research and Management
- Soft tissue tumors and treatment
- Homicide, Infanticide, and Child Abuse
- Pregnancy and preeclampsia studies
- Neuroscience and Neuropharmacology Research
- Genetically Modified Organisms Research
- Plant Genetic and Mutation Studies
- Soft tissue tumor case studies
- Ion channel regulation and function
- Identification and Quantification in Food
- Plant Virus Research Studies
- Bariatric Surgery and Outcomes
- Medical Imaging and Pathology Studies
University of Edinburgh
2016-2025
MRC Centre for Reproductive Health
2014-2025
The Queen's Medical Research Institute
2023-2025
Queen's Medical Centre
2017-2024
International Centre for Reproductive Health
2024
Medical Research Council
2021
University of Glasgow
2020
University of Bristol
2020
Plant & Food Research
2002-2017
Freeman Hospital
2007-2010
Ventilation-perfusion (VQ) scanning is used when pulmonary embolism (PE) suspected during pregnancy; however, the distribution of lung scan results and safety VQ have never been studied.To study as well withholding anticoagulation therapy following a normal or nondiagnostic in pregnant women.The group comprised 120 consecutive women who presented with PE. Clinical data were collected, scans reinterpreted by 2 independent experts. Subsequent pregnancy pediatric outcomes determined direct...
Background The genetic regulation of flower color has been widely studied, notably as a character used by Mendel and his predecessors in the study inheritance pea. Methodology/Principal Findings We genome sequence model legumes, together with their known synteny to pea identify candidate genes for A A2 loci then combination mapping, fast neutron mutant analysis, allelic diversity, transcript quantification transient expression complementation studies confirm identity candidates....
ABSTRACT Objective To examine the associations of antenatal corticosteroid (ACS) exposure with neurodevelopment in early childhood, and how these vary gestational age at birth. Design Population‐based cohort study. Setting Scotland, UK. Population 285 637 singleton children born 28–41 weeks' gestation, between 1st January 2011 31st December 2017, who underwent health reviews 27–30 months age. Methods Logistic linear regression analyses, stratified by gestation birth (28–33, 34–36, 37–38...
ABSTRACT Ascochyta blight of pea ( Pisum sativum L.) is a fungal disease caused by Mycosphaerella pinodes (Berk. & Bloxham) Verstergren, Phoma medicaginis Malbr. Roum. var. pinodella (L.K. Jones) Boerema, and pisi Lib. that can result in significant reductions to yield quality. To characterize the genetics resistance identify molecular markers for use plant breeding, quantitative trait loci (QTLs) affecting were mapped F 2:3 2:4 families produced from cross between resistant breeding...
Seed yield in pea ( Pisum sativum L.) is a physiologically complex trait that strongly influenced by both genotype and environment. can be described terms of its components, which include plant number per unit area, seed weight, number. These components show interdependence plasticity response to environment; therefore, selection based on single component unlikely succeed increasing breeding programs. To improve our understanding the genetic basis determination identify loci involved,...
Polymerase chain reaction (PCR) is being used increasingly to detect DNA sequences for food quality testing GM content, microbial contamination, and ingredient content. However, processing often results in degradation therefore may affect the suitability of PCR or even sequence detection assurance. This paper describes a novel approach using quantitative real-time (qPCR) estimate extent degradation. With use two maize endogenous nuclear sequences, sets four qPCR assays were developed amplify...
Starch phosphorylation is an important aspect of plant metabolism due to its role in starch degradation. Moreover, the degree determines physicochemical properties and therefore relevant for industrial uses starch. Currently, chemically phosphorylated increase viscosity paste stability. Potato cultivars with elevated would make this process unnecessary, thereby bestowing economic environmental benefits. a complex trait which has been previously shown by antisense gene repression be...
Although starch consists of large macromolecules composed glucose units linked by α-1,4-glycosidic linkages with α-1,6-glycosidic branchpoints, variation in structural and functional properties is found both within between species. Interest genetics based on the importance food industrial processes, potential to provide novel starches. The metabolic pathway complex but has been characterized diverse plant species, including pea. To understand how allelic pea affects structure percent...
Background Antenatal corticosteroids (ACS) are widely prescribed to improve outcomes following preterm birth. Significant knowledge gaps surround their safety, long-term effects, optimal timing and dosage. Almost half of women given ACS give birth outside the “therapeutic window” have not delivered over 7 days later. Overtreatment with is a concern, as evidence accumulates risks unnecessary exposure. Methods The Consortium for Study Pregnancy Treatments (Co-OPT) was established address...
<h3>Importance</h3> Twin pregnancies account for 3% of live births but experience substantially more perinatal morbidity and mortality than singleton pregnancies. Optimizing the timing birth is a key strategy in improving twin pregnancy outcomes. Current UK US policies are based on observational studies not longer-term effects. The association with long-term childhood outcomes among twins uncertain. <h3>Objective</h3> To identify optimal gestation week infants by calculating associated...
Pea ( Pisum sativum L.) has a genome of about 4 Gb that appears to share conserved synteny with model legumes having genomes 0.2–0.4 despite extensive intergenic expansion. plant inventory (PI) accession 269818 been used introgress genetic diversity into the cultivated germplasm pool. The aim here was develop pea bacterial artificial chromosome (BAC) libraries would enable isolation genes involved in disease resistance or control economically important traits. BAC encompassed 3.2 haploid...
Abstract BACKGROUND: Polymerase chain reaction (PCR)‐based DNA diagnostics have grown in importance for assessing food quality and safety. PCR diagnostic reliability sensitivity depend on the of extractions, including extent degradation presence inhibitors. RESULTS: An approach has been described that quantifies soy samples using anchored real‐time (qPCR) assays amplify target sequences ranging from < 100 to > 1000 bp, based two endogenous sequences. was quantified model foods produced...
Preterm delivery is a major global public health challenge. The objective of this study was to determine how preterm rates differ in country with very high human development index and explore rural vs urban environmental socioeconomic factors that may be responsible for variation.A population-based performed using data from the Swedish Medical Birth Register 1998 2013. Sweden chosen as model because its validated, routinely collected availability individual social data. total population...
The two-week "wait" target introduced in 2000 requires that patients with suspected cancer referred by general practitioners should be seen within two weeks. We reviewed who had been under this standard to the North of England Bone and Soft Tissue Tumour Service, determine if referral guidelines followed, what proportion guideline malignant tumours. 40 were between January 2004 December 2005. Ten these (2548%) tumours, compared 243 507 (48%) those from other sources. In 9 cases, patient did...
The aim of the STOPPIT-3 study is to determine clinical and cost effectiveness antenatal corticosteroids (ACS) prior planned birth twins in a multicentre placebo-controlled trial with internal pilot. This will comprise multicentre, double-blinded, randomised, at least 50 UK obstetric units. target population 1552 women twin pregnancy between 35 38+6 weeks' gestation recruited from clinics. Women be randomised Dexamethasone Phosphate (24 mg) or saline administered via two intramuscular...