A5083402180- Radiopharmaceutical Chemistry and Applications
- Peptidase Inhibition and Analysis
- Prostate Cancer Treatment and Research
- Protein Degradation and Inhibitors
- HER2/EGFR in Cancer Research
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Advanced MRI Techniques and Applications
- Medical Imaging Techniques and Applications
- Photoacoustic and Ultrasonic Imaging
- Liver physiology and pathology
- Cancer Cells and Metastasis
- Advancements in Semiconductor Devices and Circuit Design
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Adipose Tissue and Metabolism
- Advanced Neuroimaging Techniques and Applications
- Rock Mechanics and Modeling
- Congenital heart defects research
- Lignin and Wood Chemistry
- Paraoxonase enzyme and polymorphisms
- Respiratory viral infections research
- Infrared Thermography in Medicine
- Viral Infections and Immunology Research
- Polymer composites and self-healing
- Liver Diseases and Immunity
Translational Research Institute
2018-2025
Nicolaus Copernicus University
2024
The University of Queensland
2020
Mater Research
2020
Abstract Thrombosis and its complications are responsible for 30% of annual deaths. Limitations methods diagnosing treating thrombosis highlight the need improvements. Agents that provide simultaneous diagnostic therapeutic activities (theranostics) paramount an accurate diagnosis rapid treatment. In this study, silver‐iron oxide nanoparticles (AgIONPs) developed highly efficient targeted photothermal therapy imaging thrombosis. Small iron employed as seeding agents generation a new class...
Abstract Background Triple-negative breast cancers (TNBC) have a relatively poor prognosis and responses to targeted therapies. Between 25 39% of TNBCs are claudin-low, poorly differentiated subtype enriched for mesenchymal, stem cell mitogen-activated signaling pathways. We investigated the role cell-surface co-receptor NRP1 in biology claudin-low TNBC. Methods The clinical prognostic value was determined by Kaplan–Meier analysis. GSVA analysis METABRIC Oslo2 transcriptomics datasets used...
Abstract Purpose: Receptor CUB-domain containing- protein 1 (CDCP1) was evaluated as a target for detection and treatment of breast cancer. Experimental Design: CDCP1 expression assessed immunohistochemically in tumors from 423 patients (119 triple-negative cancer (TNBC); 75 HER2+; 229 ER+/HER2- including 228 primary tumors, lymph node 47 distant metastases). Cell cytotoxicity induced vitro by CDCP1-targeting antibody-drug conjugate (ADC), consisting the human/mouse chimeric antibody ch10D7...
<p>Supplementary Figures</p>
<div>AbstractPurpose:<p>Receptor CUB domain–containing protein 1 (CDCP1) was evaluated as a target for detection and treatment of breast cancer.</p>Experimental Design:<p>CDCP1 expression assessed immunohistochemically in tumors from 423 patients [119 triple-negative cancer (TNBC); 75 HER2<sup>+</sup>; 229 ER<sup>+</sup>/HER2<sup>−</sup>, including 228 primary lymph node 47 distant metastases). Cell cytotoxicity induced <i>in...
Background: CUB domain-containing protein 1 (CDCP1) is a cell surface receptor regulating key signalling pathways in malignant cells. CDCP1 has been proposed as molecular target to abrogate oncogenic and specifically deliver anti-cancer agents tumors. However, the development of CDCP1-targeting questioned by its frequent proteolytic processing which was thought result shedding extracellular domain limiting targetability. In this study, we investigated relevance targeting context pancreatic...
Influenza A virus (IAV) causes a wide range of extrarespiratory complications. However, the role host factors in these complications influenza infection remains to be defined.Here, we sought use transcriptional profiling, virology, histology, and echocardiograms investigate high-fat diet IAV-associated cardiac damage.Transcriptional profiling showed that, compared their low-fat counterparts (LF mice), mice fed (HF mice) had impairments inflammatory signaling lung heart after IAV infection....
Abstract Heritage buildings always pose challenges due to experiencing high temperatures and pressure over time. Sandstone is one of the common sedimentary rock types used for these buildings. Therefore, it very important understand microstructural variations rocks associated with constructions along mechanical variations. In this study, alteration selected sandstones investigated after heated from room temperature 800 °C. Micro X-ray computed tomography (µXCT), diffraction (XRD), scanning...
Metabolic syndrome (MetS) and a prolonged daily eating window (EW) are associated with circadian rhythm disruption increased cardiometabolic risk. Misalignment between timing system rhythms of food intake adversely impacts metabolic regulatory mechanisms cardiovascular function. Restricting the EW by imposing an eating–fasting cycle through time-restricted (TRE) can restore robust rhythms, support cellular metabolism, improve health. The aim this study was to assess feasibility 12-week TRE...
CUB-domain containing protein 1 (CDCP1) is a cancer associated cell surface that amplifies pro-tumorigenic signalling by other receptors including EGFR and HER2.Its potential as target supported studies showing anti-CDCP1 antibodies inhibit migration survival in vitro, tumor growth metastasis vivo.Here we characterize two antibodies, focusing on immuno-conjugates of one these tool to detect ovarian cancer.Methods: A panel lines was examined for expression CDCP1 loss induced 10D7 41-2 using...
Chimeric antibody Miltuximab®, a human IgG1 engineered from the parent MIL-38, is in clinical development for solid tumour therapy. Miltuximab® targets glypican-1 (GPC-1), cell surface protein involved growth, which overexpressed tumours, including prostate cancer (PCa). This study investigated potential of 89Zr-labelled as an imaging agent, and 177Lu-labelled targeted beta therapy, mouse xenograft model cancer. Male BALB/c nude mice were inoculated subcutaneously with GPC-1-positive DU-145...
Abstract Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution PSA) associated reduced risk, however, functional relevance unknown. Here, we identify that SNP variant-induced change PSA biochemical activity mediates pathogenesis. ‘Thr’ variant leads to small subcutaneous tumours, supporting risk. However, also displays higher metastatic...
ABSTRACT Resident and recruited macrophages control the development proliferation of liver. We have previously shown in multiple species that treatment with a macrophage colony stimulating factor (CSF1)-Fc fusion protein initiated hepatocyte promoted repair models acute hepatic injury mice. Here, we investigated impact CSF1-Fc on resolution advanced fibrosis liver regeneration, using non-resolving toxin-induced model chronic C57BL/6J Co-administration exposure to thioacetamide (TAA)...
Abstract Cardiac injury, such as myocardial infarction (MI), results in permanent loss of cardiomyocytes and many cases heart failure. Transgenic expression the pro-proliferative transcription factor Myc Cyclin T1 can drive substantial adult cardiomyocyte proliferation to replace lost cardiomyocytes. Herein, we show that induced leads repair functional (long-term) recovery post-MI mice. To provide a more translational approach, developed modified mRNA (modRNA) encoding Myc-Ccnt1 transient...
This study presents a novel and non-destructive method for quantitatively analysing grease lubricated bearing wear by using X-ray microcomputed tomography (μCT). The efficacy of μCT to measure rolling contact via debris analysis was demonstrated, as quantifying contamination identification. Test rig experiments spherical roller bearings, were performed simulate wear. Six samples collected from two bearings at three different intervals investigate progression. Results showed measured volume...
Obesity has serious consequences such as the onset of metabolic syndrome, type 2 diabetes, atherosclerosis, or cardiovascular complications. The aim this study was to evaluate levels paraoxonase 1 (PON1), lectin-like oxidized LDL receptor-1 (LOX-1), antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)), lipid peroxidation processes in course obesity.28 men took part experiment. Fourteen them were obese; control group consisted 14 physically active...
Rationale: An antibody-drug conjugate (ADC) is a targeted therapy consisting of cytotoxic payload that linked to an antibody which targets protein enriched on malignant cells.Multiple ADCs are currently used clinically as anti-cancer agents significantly improving patient survival.Herein, we evaluated the rationale targeting cell surface oncoreceptor CUB domain-containing 1 (CDCP1) using and assessed efficacy CDCP1-directed against range tumors.Methods: CDCP1 mRNA expression was large...
Theranostics of Thrombosis In article number 2205744, Hang Thu Ta and co-workers present a novel nanoparticle (AgIONP) for theranostics thrombosis. AgIONPs can specifically bind to thrombus. Exposure near-infrared laser leads thrombolysis restoration the blood flow. also be used as multimodal diagnostic agent.
Recent reports have suggested the role of kallikrein-related peptidase 4 (KLK4) to be that remodeling tumor microenvironment in many cancers, including prostate cancer. Notably, these studies a pro-tumorigenic for KLK4, especially However, been primarily vitro studies, with limited vivo performed date. Herein, we employed an orthotopic inoculation xenograft model mimic growth primary tumors, and intracardiac injection induce metastatic dissemination determine tumorigenic effects KLK4...
Abstract Glass ionomer (GI) cements and self‐etch (SE) or universal adhesives after etching (ER) adapt variably with dentine. Dentine characteristics vary depth (deep/shallow), location (central/peripheral), microscopic site (intertubular/peritubular). To directly compare adhesion to dentine, non‐destructive imaging testing are required. Here, GI, ER, SE adapted at different dentine depths, locations, sites were investigated using micro‐CT, xenon plasma focused ion beam scanning electron...
SUMMARY Cardiac injury and dysfunction occur in COVID-19 patients increase the risk of mortality. Causes are ill defined, but could be direct cardiac infection and/or inflammation-induced dysfunction. To identify mechanisms cardio-protective drugs, we use a state-of-the-art pipeline combining human organoids with phosphoproteomics single nuclei RNA sequencing. We an inflammatory ‘cytokine-storm’, cocktail interferon gamma, interleukin 1β poly(I:C), induced diastolic Bromodomain-containing...
Lignin, the most abundant aromatic biopolymer, is explored as a renewable polyol substituent and functional additive in rigid polyurethane foam (RPUF) for structural insulation applications. The understanding of complex microstructural changes RPUF caused by lignin micro-nanoparticles has been limited traditional two-dimensional cross-sectional imaging methods (typically to average cell diameters). This study reports induced dispersion kraft (0–2% w/w) monitored using X-ray computed...