A5029670435- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Gastrointestinal Tumor Research and Treatment
- Metastasis and carcinoma case studies
- Esophageal and GI Pathology
- Pancreatic and Hepatic Oncology Research
- Radiomics and Machine Learning in Medical Imaging
- Genetic factors in colorectal cancer
- Colorectal Cancer Treatments and Studies
- Lung Cancer Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Helicobacter pylori-related gastroenterology studies
- Lung Cancer Treatments and Mutations
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer-related gene regulation
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Epigenetics and DNA Methylation
- RNA modifications and cancer
- Radiopharmaceutical Chemistry and Applications
- Heat shock proteins research
- Head and Neck Cancer Studies
- Cancer, Hypoxia, and Metabolism
- Intraperitoneal and Appendiceal Malignancies
- Cancer-related molecular mechanisms research
Rosenheim Technical University of Applied Sciences
2014-2024
RoMed Kliniken
2015-2023
Heidelberg University
2010-2022
University Hospital Augsburg
2017
Universität Hamburg
2016
University Medical Center Hamburg-Eppendorf
2016
University Hospital Heidelberg
2008-2015
Chirurgische Universitätsklinik Heidelberg
2008-2014
Heidelberg University
2010-2013
Huashan Hospital
2011
Abstract BACKGROUND Neoadjuvant chemotherapy has shown some success in the treatment of gastric carcinoma, but objective parameters for measuring its effects are lacking. The authors performed current study to determine which histomorphologic features correlated with patient prognosis after chemotherapy. METHODS Thirty‐six patients carcinoma were treated a combination etoposide, doxorubicin, and cisplatin. entire tumor beds specimens evaluated histologically compared surgery alone....
Preoperative chemotherapy in patients with gastroesophageal cancer is hampered by the lack of reliable predictors tumor response. This study evaluates whether positron emission tomography (PET) using fluorine-18 fluorodeoxyglucose (FDG) may predict response early course therapy.Forty consecutive locally advanced adenocarcinomas esophagogastric junction were studied FDG-PET at baseline and 14 days after initiation cisplatin-based polychemotherapy. Clinical (reduction length wall thickness >...
Patients with locally advanced gastric cancer benefit from combined pre- and postoperative chemotherapy, although fewer than 50% could receive chemotherapy. We examined the value of purely preoperative chemotherapy in a phase III trial strict staging surgical resection guidelines.
A previous study suggested that measurement of therapy-induced changes in tumor glucose metabolism by positron emission tomography (PET) with the analog [18F]fluorodeoxyglucose (FDG) allows to select patients most likely benefit from preoperative chemotherapy adenocarcinomas esophagogastric junction (AEG). The aim this was prospectively validate these findings using an a priori definition metabolic response.Sixty-five locally advanced AEGs were included. Tumor utilization quantitatively...
We prospectively evaluated the predictive value of therapy-induced reduction tumor glucose use for subsequent response and patient survival in patients with gastric cancer treated by preoperative chemotherapy.Forty-four consecutive locally advanced carcinomas were studied positron emission tomography analog fluorine-18 fluorodeoxyglucose (FDG-PET) at baseline 14 days after initiation cisplatin-based polychemotherapy. On basis a previous study, FDG uptake more than 35% was used as criterion...
Previous studies demonstrated that chemotherapy-induced changes in tumor glucose metabolism measured with <sup>18</sup>F-FDG PET identify patients who benefit from preoperative chemotherapy and those do not. The prognosis for metabolic nonresponders is poorer than responders. Therefore, we initiated this prospective trial to improve the clinical outcome of using a salvage neoadjuvant radiochemotherapy. <b>Methods:</b> Fifty-six locally advanced adenocarcinomas esophagogastric junction were...
Recently, histopathological tumour regression, prevalence of signet ring cells, and localisation were reported as prognostic factors in neoadjuvantly treated oesophagogastric (junctional gastric) cancer. This exploratory retrospective study analyses independent within a large patient cohort after preoperative chemotherapy including clinical factors.In all, 850 patients presenting with cancer staged cT3/4 Nany cM0/x neoadjuvant followed by resection two academic centres. Patient data...
Die Experten haben die gesamte Leitlinie durchgesehen und auf Aktualisierungsbedarf geprüft. Folgende Änderungen sich im Vergleich zur vorherigen von 2011 ergeben:
Abstract Epstein–Barr virus positivity (EBV(+)) and high‐microsatellite instability (MSI‐H) have been identified as molecular subgroups in gastric carcinoma. The aim of our study was to determine the prognostic predictive relevance these context platinum/5‐fluorouracil (5‐FU) based preoperative chemotherapy (CTx). Additionally, we investigated clinical low‐MSI (MSI‐L) phenotype. We analysed 760 adenocarcinomas stomach or gastro‐oesophageal junction encompassing 143 biopsies before CTx 617...
We prospectively evaluated the predictive value of positron emission tomography using fluorine-18 fluorodeoxyglucose (FDG-PET) for in vivo testing chemosensitivity locally advanced gastric cancer an a priori definition metabolic response (a decrease >35% standard uptake value). The goal study was biologically different groups patients prior to or early during induction therapy, with special emphasis on FDG non-avid tumors.Based our data, which published 2003, at least 36 tumors had be...
In this pilot study, we evaluated 3′-deoxy-3′-<sup>18</sup>F-fluorothymidine (FLT) PET for the detection of gastric cancer and compared diagnostic accuracy with that <sup>18</sup>F-FDG PET. <b>Methods:</b> Forty-five patients (31 male 14 female) histologically proven locally advanced underwent attenuation-corrected whole-body <sup>18</sup>F-FLT PET/CT (low-dose CT). emission images were acquired on a full-ring scanner 45 min after injection 270–340 MBq <sup>18</sup>F-FLT. was performed 60...