A5055432986- Gastric Cancer Management and Outcomes
- Esophageal Cancer Research and Treatment
- Metastasis and carcinoma case studies
- Gastrointestinal Tumor Research and Treatment
- Esophageal and GI Pathology
- Cancer Genomics and Diagnostics
- Lung Cancer Diagnosis and Treatment
- Cancer Cells and Metastasis
- Genetic factors in colorectal cancer
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Colorectal Cancer Treatments and Studies
- Lung Cancer Treatments and Mutations
- Colorectal and Anal Carcinomas
- Cancer Research and Treatments
- Pancreatic and Hepatic Oncology Research
- Multiple and Secondary Primary Cancers
- Inflammatory Biomarkers in Disease Prognosis
- Radiopharmaceutical Chemistry and Applications
- Lung Cancer Research Studies
- Heart Failure Treatment and Management
- Molecular Biology Techniques and Applications
- Colorectal Cancer Surgical Treatments
- MicroRNA in disease regulation
- Potassium and Related Disorders
Heidelberg University
2014-2025
University Hospital Heidelberg
2014-2025
National Confidential Enquiry into Patient Outcome and Death
2023
University Hospital and Clinics
2015
Chirurgische Universitätsklinik Heidelberg
2011-2014
Frauenklinik Heidelberg
2007-2008
Universitäts Frauenklinik
2008
VEGFR-2 is expressed on tumor vasculature and a target for anti-angiogenic intervention. VXM01 first in kind orally applied vaccine based live, attenuated Salmonella bacteria carrying an expression plasmid, encoding VEGFR-2. We here studied the safety, tolerability, T effector (Teff), regulatory (Treg) humoral responses to VEGFR2 effects advanced pancreatic cancer patients randomized, dose escalation phase I clinical trial. Results of 3 mo observation period are reported. Locally or...
Perioperative systemic treatment is standard of care for Caucasian patients with locally advanced, resectable gastric adenocarcinoma. The prognostic relevance the microsatellite instability (MSI) status in undergoing neoadjuvant chemotherapy followed by resection unclear. We analyzed association MSI histological regression and clinical outcome treatment. Tumor tissue from or gastroesophageal-junction adenocarcinoma was using a mononucleotide marker panel encompassing markers BAT25, BAT26,...
Abstract Purpose Oncological esophagectomy is the mainstay in esophageal cancer treatment, but perioperative mortality remains a significant concern. Various scoring systems exist to identify patients at high risk for postoperative complications and death. In following, we aim evaluate compare these different systems. Methods We analyzed data from 714 who underwent between 2002 2021. Each patient’s was calculated using three models: International Esodata Study Group (IESG) 90-day prediction,...
Summary Early delayed gastric conduit emptying (DGCE) is a frequent complication after Ivor-Lewis esophagectomy (ILE). Despite its relevance, few studies are published using the international consensus criteria. Therefore, we aimed to assess predictors and clinical consequences of DGCE in patients ILE. This analysis represents retrospective, single-center cohort study who underwent ILE (2016–2021). was assessed by Univariable multivariable penalized LASSO logistic regression model applied...
Preclinical studies suggest that β-blockers (BBs), traditionally used for cardiovascular diseases, may improve cancer outcomes. This study assessed the effect of BB intake on oncological outcomes and response to chemotherapy in gastric (GC) patients influence ß2-adrenergic receptor (ADRB2) expression local tumor innervation. We retrospectively analyzed 361 who underwent surgery with curative intent GC after neoadjuvant at University Hospital Heidelberg. Resection specimens were...
Esophageal cancer is often marked by aggressive tumor growth and poor prognosis. Patient groups who benefit from perioperative therapy are not yet defined. The microenvironment circulating factors as possible predictors of response prognosis gain interest. This study aimed to investigate cytokines in patients' serum tissue with regard prognosis.Median survival between SCC AC was different (published previously). Lower levels CCL11 (Eotaxin-1) CXCL10 (IP-10) the were associated a better (p =...
Introduction In the past, elderly patients with upper GI cancers were excluded from surgery or multimodal treatment only due to their advanced age. an aging society this way of patient selection seems be questionable. The aim retrospective exploratory study was investigate how cancer over age 70 years differ younger in postoperative course and which parameters influence overall survival older populations. Patients Methods From 2002 2012 1,005 underwent resection esophageal gastric at...
According to the results of FLOT4 trial, perioperative FLOT chemotherapy improved overall survival (OS) in locally advanced, resectable esophagogastric adenocarcinoma (EGA) compared ECF/ECX. We report real-life data 10 years after introduction at our institution.
Despite multimodal therapy esophageal cancer often presents with poor prognosis. To improve outcome, tumor angiogenesis and anti-angiogenic therapeutic agents have recently gained importance. However, patient subgroups who benefit from are not yet defined. In this retrospective exploratory study we investigated 9 angiogenic factors in patients' serum tissue samples regard to their association clinicopathological parameters, prognosis response patients locally advanced preoperatively treated...
Introduction: The incidence of early-onset gastric adenocarcinoma (patients <50 years, EOGA) is rising. Tumors in younger patients are associated with prognostically unfavorable features. impact EOGA on patient survival, however, remains unclear. aim this study to evaluate age as a prognostic factor compared late-onset (LOGA, >50years) surgical cohort and assess treatment options. Methods: We analyzed 738 (129 early-onset/609 late-onset) operated curative intent from 2002 2021. Data was...
Abstract Background The risk for recurrence in patients with distal gastric cancer can be reduced by surgical radicality. However, dispute exists about the value of proposed minimum proximal margin distance (PMD). Here, we assess prognostic safety between resection and tumor. Patients Methods This is a single-center cohort study undergoing gastrectomy adenocarcinoma (2001–2021). Cohorts were defined adequacy PMD according to European Society Medical Oncology (ESMO) guidelines (≥ 5 cm...
Abstarct Background Early recurrence after esophagectomy is often used as a surrogate for aggressive tumor biology and treatment failure. However, there no standardized definition of early recurrence, predictors are unknown. Therefore, we aimed to define an evidence-based cutoff discriminate late assess the influence neoadjuvant modalities patients with esophageal or gastroesophageal-junction adenocarcinoma (EAC). Patients Methods This dual-center retrospective cohort study included who...
Neoadjuvant multimodality treatment is frequently applied to improve the poor prognosis of locally advanced adenocarcinomas gastroesophageal junction. This study aimed asses if serum microRNA profiles are useable as response indicators in this therapeutic setting. Fifty patients with junction were included study. All received neoadjuvant therapy and subsequently underwent surgical resection. Histomorphologic regression was defined major histopathological when resected specimens contained...
The objective was to provide evidence for age-dependent use of neoadjuvant treatment by clinical comparisons young (lower quartile, <56.6 years) versus old (upper >71.3 patients with esophageal and esophagogastric-junction adenocarcinoma.