A5048229400- Air Quality and Health Impacts
- Carcinogens and Genotoxicity Assessment
- Nutrition, Genetics, and Disease
- MicroRNA in disease regulation
- Epigenetics and DNA Methylation
- Liver Disease and Transplantation
- Toxic Organic Pollutants Impact
- Gene expression and cancer classification
- Effects and risks of endocrine disrupting chemicals
- Genomics, phytochemicals, and oxidative stress
- Organ Transplantation Techniques and Outcomes
- Water Treatment and Disinfection
- Adipose Tissue and Metabolism
- Birth, Development, and Health
- Health, Environment, Cognitive Aging
- Drug-Induced Hepatotoxicity and Protection
- Sulfur Compounds in Biology
- Metabolomics and Mass Spectrometry Studies
- Molecular Biology Techniques and Applications
- BRCA gene mutations in cancer
- Nutritional Studies and Diet
- Colorectal Cancer Treatments and Studies
- Drug Transport and Resistance Mechanisms
- Colorectal Cancer Screening and Detection
- Antioxidant Activity and Oxidative Stress
Maastricht University
2016-2025
Maastricht University Medical Centre
2014-2024
University Medical Center
1981-2023
Netherlands Metabolomics Centre
2009-2016
University Medical Center Groningen
2006-2011
University of Groningen
1981-2011
Dialyse Centrum Groningen
2011
The Netherlands Cancer Institute
2005-2010
Radboud University Medical Center
2005-2010
Leiden University Medical Center
2005-2010
The value of regular surveillance for breast cancer in women with a genetic or familial predisposition to is currently unproven. We compared the efficacy magnetic resonance imaging (MRI) that mammography screening this group high-risk women.Women who had cumulative lifetime risk 15 percent more were screened every six months clinical examination and once year by MRI, independent readings. characteristics cancers detected those two different age-matched control groups.We 1909 eligible women,...
The Dutch MRI Screening Study on early detection of hereditary breast cancer started in 1999. We evaluated the long-term results including separate analyses BRCA1 and BRCA2 mutation carriers first survival.Women with higher than 15% cumulative lifetime risk (CLTR) were screened biannual clinical examination annual mammography magnetic resonance imaging (MRI). Participants divided into subgroups: a gene (50% to 85% CLTR) two familial groups high (30% 50% or moderate (15% 30% CLTR).Our update...
This paper is based on a workshop held in Oslo, Norway November 2013, which experts discussed how to reach consensus the healthiness of red and processed meat. Recent nutritional recommendations include reducing intake meat reduce cancer risk, particular colorectal (CRC). Epidemiological mechanistic data associations between CRC are inconsistent underlying mechanisms unclear. There need for further studies differences white meat, whole different types meats, as potential health risks may not...
Since 1969, the European Union approves food-grade titanium dioxide (TiO2), also known as E171 colouring food additive. is a mixture of micro-sized particles (MPs) and nano-sized (NPs). Previous studies have indicated adverse effects oral exposure to E171, i.e. facilitation colon tumour growth. This could potentially be partially mediated by capacity induce reactive oxygen species (ROS). The aim present study determine whether induces ROS formation DNA damage in an vitro model using human...
The suitability for omic analysis of biosamples collected in previous decades and currently stored biobanks is unknown.We evaluated the influence handling storage conditions blood-derived on transcriptomic, epigenomic (CpG methylation), plasma metabolomic [UPLC-ToFMS (ultra performance liquid chromatography-time-of-flight mass spectrometry)], wide-target proteomic profiles.We fresh blood samples without RNA preservative heparin, EDTA, or citrate held them at room temperature ≤ 24 hr before...
Abstract Understanding adipose tissue cellular heterogeneity and homeostasis is essential to comprehend the cell type dynamics in metabolic diseases. Cellular subpopulations have been related disease development, but efforts towards characterizing composition are limited. Here, we identify of by using gene expression deconvolution large amounts publicly available transcriptomics level data. The proposed approach allows present a comprehensive study composition, determining relative 21...
Reactive oxygen species (ROS), possibly produced during the metabolic conversion of benzo(a)pyrene (B[a]P), could be involved in B[a]P-induced genotoxicity and, eventually, carcinogenicity. Therefore, ROS formation by rat lung and liver microsomes was studied vitro electron spin resonance (ESR/EPR) spectrometry. B[a]P-mediated generation detected incubations with lung, but not microsomes. Inhibition cytochrome P450 (CYP450) non isoform-specific inhibitor SKF-525A resulted a complete...
Abstract Exposure to ambient particulate matter (PM) has been linked several adverse health effects. Since vehicular traffic is a PM source of growing importance, we sampled total suspended (TSP), 10 , and 2.5 at six urban locations with pronounced differences in intensity. The mutagenicity, DNA‐adduct formation, induction oxidative DNA damage by the samples were studied as genotoxicological parameters, relation polycyclic aromatic hydrocarbon (PAH) levels, elemental composition,...
Several authors have suggested that it is safe to raise the health standard for nitrate in drinking water, and save money on measures associated with pollution of water resources. The major argument has been epidemiologic evidence acute chronic effects related at concentrations near inconclusive. With respect effects, was motivated by absence adverse ingestion from dietary sources. An interdisciplinary discussion these arguments led three important observations. First, there only a few...
The appearance of malignant lesions in BRCA1 and BRCA2 mutation carriers (BRCA-MCs) on mammography magnetic resonance imaging (MRI) was evaluated. Thus, 29 BRCA-MCs with breast cancer were retrospectively evaluated the results compared an age, tumor size type matched control group sporadic cases. Detection rates both modalities Tumors analyzed morphology, density (mammography), enhancement pattern kinetics (MRI). Overall detection significantly better MRI than (55/58 vs 44/57, P = 0.021). On...
Presently, health costs associated with nitrate in drinking water are uncertain and not quantified. This limits proper evaluation of current policies measures for solving or preventing pollution resources. The cost society is also relevant integrated assessment EU nitrogen taking a perspective welfare optimization. overarching question at which mitigation level the social measures, including their consequence availability food energy, matches benefit these human biodiversity. Epidemiological...