Lars Frost

ORCID: 0000-0001-9215-9796
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About
Contact & Profiles
Research Areas
  • Atrial Fibrillation Management and Outcomes
  • Cardiac Imaging and Diagnostics
  • Cardiac Arrhythmias and Treatments
  • Cardiac electrophysiology and arrhythmias
  • Health Systems, Economic Evaluations, Quality of Life
  • Cardiovascular Function and Risk Factors
  • Acute Myocardial Infarction Research
  • Venous Thromboembolism Diagnosis and Management
  • Acute Ischemic Stroke Management
  • Aortic aneurysm repair treatments
  • Cardiac, Anesthesia and Surgical Outcomes
  • Coronary Interventions and Diagnostics
  • Blood Pressure and Hypertension Studies
  • Cardiac Health and Mental Health
  • Cardiovascular Disease and Adiposity
  • Aortic Disease and Treatment Approaches
  • Phonocardiography and Auscultation Techniques
  • Heart Failure Treatment and Management
  • Antiplatelet Therapy and Cardiovascular Diseases
  • Healthcare cost, quality, practices
  • ECG Monitoring and Analysis
  • Heart Rate Variability and Autonomic Control
  • Advanced MRI Techniques and Applications
  • Cervical Cancer and HPV Research
  • Health Promotion and Cardiovascular Prevention

Regional Hospital Central Jutland
2016-2025

Regionshospitalet Silkeborg
2016-2025

Aarhus University
2016-2025

Aarhus University Hospital
2013-2024

Gateshead Health NHS Foundation Trust
2024

Pathways Behavioral Services
2024

Aalborg University
2021-2023

University of Liverpool
2021-2022

Liverpool Heart and Chest Hospital
2021-2022

Laboratoire Informatique d'Avignon
2022

<h3>Abstract</h3> <h3>Objective</h3> To examine the association between risk factor burdens—categorized as optimal, borderline, or elevated—and lifetime of atrial fibrillation. <h3>Design</h3> Community based cohort study. <h3>Setting</h3> Longitudinal data from Framingham Heart Study. <h3>Participants</h3> Individuals free fibrillation at index ages 55, 65, and 75 years were assessed. Smoking, alcohol consumption, body mass index, blood pressure, diabetes, history heart failure myocardial...

10.1136/bmj.k1453 article EN cc-by-nc BMJ 2018-04-26

Limited data suggest a benefit of population-based screening for cardiovascular disease with respect to the risk death.We performed population-based, parallel-group, randomized, controlled trial involving men 65 74 years age living in 15 Danish municipalities. The participants were randomly assigned 1:2 ratio undergo (the invited group) or not control subclinical disease. Randomization was based on computer-generated random numbers and stratified according municipality. Only group unaware...

10.1056/nejmoa2208681 article EN New England Journal of Medicine 2022-08-27

Background: Atrial fibrillation is a common cardiac manifestation of hyperthyroidism.The relation between hyperthyroidism and atrial has so far been analyzed in limited number selected patients, the strength association not estimated.We examined risk among patients aged 20 to 89 years with diagnosed hospitals Denmark during 20-year period. Methods:We identified all an incident hospital diagnosis study period Danish National Registry Patients, those we or flutter that occurred ±30 days from...

10.1001/archinte.164.15.1675 article EN Archives of Internal Medicine 2004-08-09

The evidence for an association between alcohol consumption and risk of atrial fibrillation is conflicting.We prospectively examined the or flutter among 47 949 participants (mean age, 56 years) in Danish Diet, Cancer, Health Study. was analyzed as sex-specific quintiles by Cox proportional hazards regression models.The mean +/- SD per day 28.2 25 g men 13.9 15 women. During follow-up (mean, 5.7 years), developed 556 subjects (374 182 women). After adjusting established factors, there a...

10.1001/archinte.164.18.1993 article EN Archives of Internal Medicine 2004-10-11

256 asthmatic children receiving regular inhalation therapy demonstrated how they used their inhalers. Pulmonary function measurements (PFM) were made before and after the demonstrations, errors in technique recorded. 242 had reversible airway obstruction on day of study. In only 109 (45%) did result an increase FEV1 greater than or equal to 15% (efficient technique). An efficient was found 46% who a pressurized aerosol, 59% tube spacer aerosol rotahaler, frequency varied from 17% 84%...

10.1111/j.1398-9995.1986.tb00287.x article EN Allergy 1986-02-01

The impact of atrial fibrillation (AF) on risk peripheral arterial thromboembolism is unknown.We analyzed the (embolus and/or thrombosis) in aorta and renal, mesenteric, pelvic, extremity arteries a cohort patients discharged from hospital with an incident diagnosis AF relative to these vessels Danish population. In random sample half population, 14 917 men 945 women aged 50 89 years were identified National Hospital Discharge Register January 1, 1980, through December 31, 1993. Patients...

10.1001/archinte.161.2.272 article EN Archives of Internal Medicine 2001-01-22

10.1093/ajcn/81.3.578 article EN publisher-specific-oa American Journal of Clinical Nutrition 2005-03-01

A follow‐up study of 202 children who had received hyposensitization with aluminium‐containing allergens showed that 1–3 years after cessation 13 still severely pruiginous treatment‐resistant subcutaneous nodules in their forearms. Because long persistence the six were studied detail. Histologically, infiltration lymphocytes (forming germinal centres), macrophages, plasma cells, mast cells and a few cosinophils. In five patients aluminium crystals found scattered between and, addition,...

10.1111/j.1398-9995.1985.tb00249.x article EN Allergy 1985-07-01

10.1016/j.jacc.2017.03.558 article EN publisher-specific-oa Journal of the American College of Cardiology 2017-05-01

It is recognized that higher height and weight are associated with risk of atrial fibrillation or flutter (AF) but it unclear whether AF related to body fat, fat location, lean mass.This article reports the Danish population-based prospective cohort Diet, Cancer Health study conducted among 55,273 men women 50-64 years age at recruitment. The associations between bioelectrical impedance derived measures composition combinations anthropometric distribution an incident record in Registry...

10.1002/oby.20706 article EN Obesity 2014-01-17

The significant increase in the average life expectancy has increased societal challenge of managing serious age-related diseases, especially cancer and cardiovascular diseases. A routine check by a general practitioner is not sufficient to detect incipient disease. Population-based randomized clinically controlled screening trial. Participants: 45,000 Danish men aged 65–74 years living on Island Funen, or surrounding communities Vejle Silkeborg. No exclusion criteria are used....

10.1186/s13063-015-1082-6 article EN cc-by Trials 2015-12-01

Background Atrial fibrillation ( AF ) and cancer are frequent diseases worldwide. The timewise association between the diagnosis of a subsequent may clarify whether mutual cause exists, also guide clinicians about time windows high risk occurrence. Methods Results We conducted population‐based cohort study among 26 222 men 28 879 women free at baseline based on Danish Diet, Cancer Health study. participants were followed for development (the National Patient Registry) until 2013. used Cox...

10.1161/jaha.118.009543 article EN cc-by-nc-nd Journal of the American Heart Association 2018-09-04

Abstract Objective To assess temporal trends in the association between newly diagnosed atrial fibrillation and death. Design Community based cohort study. Setting Framingham Heart Study cohort, 1972-85, 1986-2000, 2001-15 (periods 1-3, respectively), Framingham, MA, USA. Participants with no fibrillation, aged 45-95 each time period, identified (or flutter) during period. Main outcome measures The main was all cause mortality. Hazard ratios for varying mortality were calculated adjustment...

10.1136/bmj.m2724 article EN cc-by-nc BMJ 2020-08-11

Perfusion scans after coronary computed tomography angiography (CCTA) in patients with suspected artery disease (CAD) may reduce unnecessary invasive angiographies (ICAs). However, the diagnostic accuracy of perfusion primary CCTA is unknown. The aim this study was to determine cardiac magnetic resonance (CMR) and myocardial scintigraphy (MPS) against ICA fractional flow reserve (FFR) CAD by CCTA.Included were consecutive (1675) referred symptoms low/intermediate risk profile. Patients based...

10.1093/ehjci/jex342 article EN European Heart Journal - Cardiovascular Imaging 2017-12-17

In a prospective open study the sterility of uterine cavity was evaluated in 99 women admitted for hysterectomy. The indications hysterectomy were most cases persistent irregular vaginal bleeding and fibromyomas uterus. Samples both aerobic anaerobic bacteria, Chlamydia trachomatis , yeasts viruses taken preoperatively from apex vagina cervical of. Immediately after uterus opened under sterile conditions samples obtained isthmus fundus microbiological examination. Wet smears same sites....

10.3109/00016349509008942 article EN Acta Obstetricia Et Gynecologica Scandinavica 1995-03-01

<h3>Objective</h3> European ST-segment elevation myocardial infarction (STEMI) guidelines recommend prehospital diagnosis to facilitate early reperfusion in patients with STEMI, and they provide recommendations regarding optimal system delay (time from first medical contact (FMC) the primary percutaneous coronary intervention (PPCI)). There are limited data on achievable delays an STEMI of care using triage directly (PCI) centres. We examined proportion tentative diagnoses established by...

10.1136/heartjnl-2013-304576 article EN Heart 2014-03-17

Coronary computed tomography angiography (CCTA) is an established method for ruling out coronary artery disease (CAD). Most patients referred CCTA do not have CAD and only approximately 20–30 % of are subsequently to further testing by invasive (ICA) or non-invasive perfusion evaluation due suspected obstructive CAD. In cases with severe calcifications, a discrepancy between ICA often occurs, leading the well-described, low-diagnostic specificity CCTA. As cost consuming involves risk...

10.1186/s13063-016-1388-z article EN cc-by Trials 2016-05-26
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