A5031595802- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Trauma Management and Diagnosis
- Intensive Care Unit Cognitive Disorders
- Trauma and Emergency Care Studies
- Cardiac Ischemia and Reperfusion
- Cardiovascular Function and Risk Factors
- Diet and metabolism studies
- Bariatric Surgery and Outcomes
- Cardiac electrophysiology and arrhythmias
- Ion channel regulation and function
- Sepsis Diagnosis and Treatment
- Emergency and Acute Care Studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Valve Diseases and Treatments
- Advanced Proteomics Techniques and Applications
- Protease and Inhibitor Mechanisms
- Cardiac Imaging and Diagnostics
- Genomics and Rare Diseases
- Adipose Tissue and Metabolism
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Hemodynamic Monitoring and Therapy
- Peptidase Inhibition and Analysis
Copenhagen University Hospital
2018-2024
Rigshospitalet
2016-2024
University of Southern Denmark
2024
Odense University Hospital
2024
University of Copenhagen
2015-2017
Danish National Research Foundation
2017
Extracorporeal cardiopulmonary resuscitation (ECPR) can be considered in selected patients with refractory cardiac arrest. Given the risk of patient futility and high resource utilisation, identifying ECPR candidates, who would benefit from this therapy, is crucial. Previous studies investigating lactate as a potential prognostic marker have been small inconclusive. In study, it was hypothesised that level (immediately prior to initiation ECPR) clearance (within 24 hours after initiation)...
Mechanical circulatory support (MCS) with either extracorporeal membrane oxygenation or Impella has shown potential as a salvage therapy for patients refractory out-of-hospital cardiac arrest (OHCA). The objective of this study was to describe the gradual implementation, survival and adherence national consensus respect use MCS OHCA in Denmark, identify factors associated outcome.This retrospective, observational cohort included receiving at all tertiary centers (n = 4) Denmark between July...
BackgroundExtracorporeal cardiopulmonary resuscitation (ECPR) for selected refractory out-of-hospital cardiac arrest (OHCA) is increasingly used. Detailed knowledge of health-related quality life (HRQoL) and long-term cognitive function limited. HRQoL were assessed in ECPR-survivors OHCA-survivors with prehospital return spontaneous circulation after standard advanced support (sACLS).MethodsFifteen 22 age-matched sACLS-survivors agreed to participate this follow-up study. Participants...
Objective To study adipose tissue mitochondrial respiration and lipolysis following a massive weight loss. Methods High resolution respirometry of biopsies tracer determined whole body lipolysis. Sixteen obese patients with type 2 diabetes (T2DM) 27 without (OB) were studied loss by diet Roux‐en‐Y gastric bypass (RYGB). Results The respiratory rates similar in OB T2DM, the mass‐specific oxygen flux increased significantly 4 18 months post‐surgery ( P < 0.05). With normalization to...
Genetic and genomic research has greatly advanced our understanding of heart disease. Yet, comprehensive, in-depth, quantitative maps protein expression in hearts living humans are still lacking. Using samples obtained during valve replacement surgery patients with mitral prolapse (MVP), we set out to define inter-chamber differences, the intersect proteomic data genetic or datasets, impact left atrial dilation on proteome no history fibrillation (AF).We collected biopsies from right atria...
The prognosis in refractory out-of-hospital cardiac arrest (OHCA) with ongoing cardiopulmonary resuscitation (CPR) at hospital arrival is often considered dismal. use of extracorporeal (eCPR) for perfusion enhancement during has shown variable results. We aimed to investigate outcome OHCA patients managed conservatively without eCPR. included consecutive or prehospital return spontaneous circulation (ROSC) the Copenhagen area 2002–2011. A total 3992 attempts were included; 2599, treatment...
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) with profound left ventricular (LV) failure is associated inadequate LV emptying. To unload the LV, VA-ECMO can be combined Impella CP (ECMELLA). We hypothesized that ECMELLA improves cardiac energetics compared in a porcine model of cardiogenic shock (CS).
Objective To describe characteristics of patients admitted with refractory cardiac arrest for possible extracorporeal cardiopulmonary resuscitation (ECPR) and gain insight into the reasons refraining from treatment in some. Methods Nationwide retrospective cohort study involving all tertiary centres providing ECPR Denmark. Consecutive ongoing chest compression evaluation were enrolled. Presenting characteristics, duration no-flow low-flow time, end-tidal carbon dioxide (ETCO 2 ), lactate pH,...
In refractory out-of-hospital cardiac arrest (OHCA) with prolonged whole-body ischaemia, global tissue injury proceeds even after establishment of circulation extracorporeal cardiopulmonary resuscitation (ECPR). We aimed to investigate the role biomarkers reflecting hypoperfusion, inflammation, and organ in prognostication patients OHCA managed ECPR. This nationwide retrospective study included 226 adults ECPR Denmark (2011-2020). Biomarkers first days ECPR-initiation were assessed. Odds...
Objectives. Implantable cardioverter defibrillator (ICD) implantation in patients resuscitated from out-of-hospital cardiac arrest (OHCA) due to acute myocardial infarction (AMI) is controversial. Design. Consecutive OHCA-survivors AMI two Danish tertiary heart centers 2007 2011 were included. Predictors of ICD-implantation, ICD-therapy and long-term survival (5 years) investigated. Patients with without ICD-implantation during the index hospital admission included (later described as early...
Background Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory out‐of‐hospital cardiac arrest (OHCA). However, survivors managed with ECPR are at risk of poor functional status. The purpose this study was to investigate return work (RTW) after OHCA. Methods and Results Of 44 360 patients OHCA in the period 2011 2020, nationwide registry‐based included 805 working age (18–65 years) who were employed before (2% total cohort). Demographics, prehospital...
Abstract Background In selected cases of cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is combined with trans valvular micro axial flow pumps (ECMELLA). Observational studies indicate that ECMELLA may reduce mortality but exposing the patient to two advanced mechanical support devices affect early inflammatory response. We aimed explore biomarkers in a porcine shock model managed V-A ECMO or ECMELLA. Methods Fourteen landrace pigs had acute myocardial...
Background The relationship between speckle tracking assessed global longitudinal strain (GLS) and Doppler-based echocardiography with basic physiological markers of cardiac function derived from pressure-volume loops is poorly elucidated. Objective We aimed to describe the association LS direct measurements central haemodynamic parameters conductance catheter-based in an animal model increasing left ventricular (LV) dysfunction. Methods 12 Danish landrace female pigs (75–80 kg) were used....
Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): Rigshospitalets and Odense Universitetshospitals common foundation Background Survival after refractory out-of-hospital cardiac arrest (OHCA) is low. Extracorporeal cardiopulmonary resuscitation (ECPR) increasingly used for selected patients aiming to increase survival OHCA. However, ECPR resource heavy carries risk poor functional status. Previous studies have shown favorable neurological outcome in the...
Abstract Funding Acknowledgements Type of funding sources: None. Background Recent guidelines recommend centralisation post-resuscitation care in out-of-hospital cardiac arrest (OHCA) patients dedicated Cardiac Arrest Centres (CACs) aiming to improve outcome. Purpose To describe the process implementation policy and impact on 30-day mortality rate. Methods This nationwide study included all adult OHCA (&gt;18 years) based Danish Registry. Centralisation was introduced 2009, 2010, 2012...
Abstract Background Echocardiography is a diagnostic cornerstone in acute cardiovascular care. However, the relationship between speckle tracking assessed global longitudinal strain (LS) and Doppler-based echocardiography with basic physiological markers of cardiac function derived from pressure-volume loops remains poorly elucidated, especially increasing levels myocardial damage. Objectives We aimed to describe association LS direct measurements central hemodynamic parameters conductance...
Abstract Background The use of veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is in severe cases left ventricular (LV) failure associated with pulmonary edema due to inadequate LV emptying. In clinical practice VA-ECMO may be combined Impella CP (ECMELLA), unload the LV. We hypothesized that ECMELLA improves cardiac energetics without compromising end-organ perfusion compared alone a porcine model cardiogenic shock (CS). Methods Land-race pigs (weight 70 kg) were instrumented,...
Abstract Background In refractory out-of-hospital cardiac arrest (OHCA) with prolonged whole-body ischemia, global tissue injury proceeds even after establishment of circulation extracorporeal cardiopulmonary resuscitation (ECPR). Purpose We aimed to investigate the role biomarkers reflecting hypoperfusion, inflammation, and organ in prognostication patients OHCA managed ECPR. Methods This nationwide retrospective study included 226 adults ECPR Denmark (2011–2020). Biomarkers at admission...
Abstract Background Extracorporeal cardiopulmonary resuscitation (ECPR) is a potential salvage therapy for selected patients with refractory out-of-hospital cardiac arrest (OHCA). Purpose The objective of this study was to describe the characteristics ECPR patients. Methods This retrospective, observational cohort included 579 admitted OHCA possible at all tertiary centers in Denmark between 2015 and 2020. Presenting characteristics, reasons refraining from ECPR, survival hospital discharge...