A5026283332- Mechanical Circulatory Support Devices
- Cardiac Arrest and Resuscitation
- Cardiac Structural Anomalies and Repair
- Cardiac Imaging and Diagnostics
- Acute Myocardial Infarction Research
- Cardiac Valve Diseases and Treatments
- Trauma and Emergency Care Studies
- Hemoglobinopathies and Related Disorders
- Cardiovascular Function and Risk Factors
- Cardiac Ischemia and Reperfusion
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Infective Endocarditis Diagnosis and Management
- Intensive Care Unit Cognitive Disorders
- Adrenal and Paraganglionic Tumors
- Hormonal Regulation and Hypertension
- Venous Thromboembolism Diagnosis and Management
- Acute Myeloid Leukemia Research
- Cardiovascular Effects of Exercise
- Bone and Joint Diseases
- Trauma Management and Diagnosis
- Cardiac pacing and defibrillation studies
- Sepsis Diagnosis and Treatment
- Acute Ischemic Stroke Management
- Adrenal Hormones and Disorders
- Hemodynamic Monitoring and Therapy
Odense University Hospital
2018-2024
University of Southern Denmark
2024
University of Pretoria
2008-2024
Kongsberg Innovasjon (Norway)
2019
Odense Municipality
2018
Extracorporeal cardiopulmonary resuscitation (ECPR) can be considered in selected patients with refractory cardiac arrest. Given the risk of patient futility and high resource utilisation, identifying ECPR candidates, who would benefit from this therapy, is crucial. Previous studies investigating lactate as a potential prognostic marker have been small inconclusive. In study, it was hypothesised that level (immediately prior to initiation ECPR) clearance (within 24 hours after initiation)...
Mechanical circulatory support (MCS) with either extracorporeal membrane oxygenation or Impella has shown potential as a salvage therapy for patients refractory out-of-hospital cardiac arrest (OHCA). The objective of this study was to describe the gradual implementation, survival and adherence national consensus respect use MCS OHCA in Denmark, identify factors associated outcome.This retrospective, observational cohort included receiving at all tertiary centers (n = 4) Denmark between July...
BackgroundExtracorporeal cardiopulmonary resuscitation (ECPR) for selected refractory out-of-hospital cardiac arrest (OHCA) is increasingly used. Detailed knowledge of health-related quality life (HRQoL) and long-term cognitive function limited. HRQoL were assessed in ECPR-survivors OHCA-survivors with prehospital return spontaneous circulation after standard advanced support (sACLS).MethodsFifteen 22 age-matched sACLS-survivors agreed to participate this follow-up study. Participants...
The aim of this study was to evaluate the Impella CP over veno-arterial extracorporeal membrane oxygenation (VA-ECMO) and their impact on left ventricular unloading end-organ perfusion.Cardiogenic shock (CS) induced by injecting microspheres into coronary artery in fourteen adult female swine. or VA-ECMO initiated presence CS evaluated after 60 minutes. Left pressure-volume area (PVA, total mechanical work) obtained from a conductance catheter. Results are presented as mean (95% confidence...
Veno-arterial extracorporeal membrane oxygenation (VA-ECMO) with profound left ventricular (LV) failure is associated inadequate LV emptying. To unload the LV, VA-ECMO can be combined Impella CP (ECMELLA). We hypothesized that ECMELLA improves cardiac energetics compared in a porcine model of cardiogenic shock (CS).
Abstract Aims The aims of this study were to investigate the correlation and sex differences between total valve calcium, calcium concentration, aortic calcification (AVC) in explanted valves from patients with severe stenosis undergoing replacement (AVR). Methods results Sixty-nine (AS) scheduled for elective AVR underwent echocardiography cardiac computed tomography (CT) prior surgery (AVCin vivo) CT (AVCex vivo). Explanted prepared acid solution, sonicated, analysed Arsenazo III dye...
Objective To describe characteristics of patients admitted with refractory cardiac arrest for possible extracorporeal cardiopulmonary resuscitation (ECPR) and gain insight into the reasons refraining from treatment in some. Methods Nationwide retrospective cohort study involving all tertiary centres providing ECPR Denmark. Consecutive ongoing chest compression evaluation were enrolled. Presenting characteristics, duration no-flow low-flow time, end-tidal carbon dioxide (ETCO 2 ), lactate pH,...
Background: The clinical spectrum of acute myocardial infarction complicated by cardiogenic shock (AMICS) varies. Out-of-hospital cardiac arrest (OHCA) can be the first sign failure, whereas others present with various degrees hemodynamic instability (non-OHCA). aim study was to explore differences in prehospital management and characteristics survivors nonsurvivors AMICS patients OHCA or non-OHCA. Methods: Data analysis based on patient data from RETROSHOCK cohort comprising consecutive...
In refractory out-of-hospital cardiac arrest (OHCA) with prolonged whole-body ischaemia, global tissue injury proceeds even after establishment of circulation extracorporeal cardiopulmonary resuscitation (ECPR). We aimed to investigate the role biomarkers reflecting hypoperfusion, inflammation, and organ in prognostication patients OHCA managed ECPR. This nationwide retrospective study included 226 adults ECPR Denmark (2011-2020). Biomarkers first days ECPR-initiation were assessed. Odds...
ABSTRACT Introduction: Despite advances in treatment of patients with cardiogenic shock following acute myocardial infarction (AMICS) in-hospital mortality remains around 50%. Outcome varies among patient subsets and the elderly often have a poor priori prognosis. We sought to investigate outcome AMICS referred evaluation at tertiary university hospital. Methods: Current analysis was based on RETROSHOCK registry comprising consecutive admitted care. Patients were individually identified...
Background Vasoactive treatment is a cornerstone in treating hypoperfusion cardiogenic shock following acute myocardial infarction (AMICS). The purpose was to compare the achievement of targets and outcome relation vasoactive strategy AMICS patients stratified according Society Cardiovascular Angiography Interventions (SCAI) classification. Methods Retrospective analysis with admitted cardiac intensive care unit at two tertiary centers during 2010–2017 retrieval real-time hemodynamic data...
Background Cardiogenic shock complicating acute myocardial infarction is associated with a high mortality rate. after out‐of‐hospital cardiac arrest (OHCA) can be due to transient stunning but also reflect the increasing severity of ongoing heart failure. The Society for Cardiovascular Angiography and Interventions (SCAI) proposed division cardiogenic into 5 phenotypes, being modifier. objective was apply SCAI classification well‐characterized OHCA population describe hemodynamic...
Objectives. Implantable cardioverter defibrillator (ICD) implantation in patients resuscitated from out-of-hospital cardiac arrest (OHCA) due to acute myocardial infarction (AMI) is controversial. Design. Consecutive OHCA-survivors AMI two Danish tertiary heart centers 2007 2011 were included. Predictors of ICD-implantation, ICD-therapy and long-term survival (5 years) investigated. Patients with without ICD-implantation during the index hospital admission included (later described as early...
Background Extracorporeal cardiopulmonary resuscitation (ECPR) is increasingly used for refractory out‐of‐hospital cardiac arrest (OHCA). However, survivors managed with ECPR are at risk of poor functional status. The purpose this study was to investigate return work (RTW) after OHCA. Methods and Results Of 44 360 patients OHCA in the period 2011 2020, nationwide registry‐based included 805 working age (18–65 years) who were employed before (2% total cohort). Demographics, prehospital...
Abstract Background In selected cases of cardiogenic shock, veno-arterial extracorporeal membrane oxygenation (V-A ECMO) is combined with trans valvular micro axial flow pumps (ECMELLA). Observational studies indicate that ECMELLA may reduce mortality but exposing the patient to two advanced mechanical support devices affect early inflammatory response. We aimed explore biomarkers in a porcine shock model managed V-A ECMO or ECMELLA. Methods Fourteen landrace pigs had acute myocardial...
Background The relationship between speckle tracking assessed global longitudinal strain (GLS) and Doppler-based echocardiography with basic physiological markers of cardiac function derived from pressure-volume loops is poorly elucidated. Objective We aimed to describe the association LS direct measurements central haemodynamic parameters conductance catheter-based in an animal model increasing left ventricular (LV) dysfunction. Methods 12 Danish landrace female pigs (75–80 kg) were used....
Background: Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) is associated with high mortality. Transient stunning seen after out-of-hospital cardiac arrest (OHCA) often presents similar clinical characteristics as CS upon hospital arrival. OHCA involves a sudden cessation of circulation followed by low-flow period during resuscitation, while prolonged dysfunction leading to hypoperfusion. The Society for Cardiovascular Angiography and Interventions (SCAI) proposed five...
Background The response of the left ventricle to cardiogenic shock (CS) caused by right ventricular (RV) infarction and effect treatment with either vasoactive or Impella RP are not well described. We sought determine RV longitudinal strain (LS) echocardiography after initiation for CS induced coronary artery embolization. Methods Results was microsphere embolization in 20 pigs. Shock defined as a reduction cardiac output ≥50% and/or an SvO