A5006919746- Cardiac Arrest and Resuscitation
- Mechanical Circulatory Support Devices
- Sepsis Diagnosis and Treatment
- Trauma and Emergency Care Studies
- Migraine and Headache Studies
- Traumatic Brain Injury and Neurovascular Disturbances
- Thermal Regulation in Medicine
- Intensive Care Unit Cognitive Disorders
- Respiratory Support and Mechanisms
- Metabolomics and Mass Spectrometry Studies
- Traumatic Brain Injury Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Cardiac Structural Anomalies and Repair
- Acute Myocardial Infarction Research
- Hemodynamic Monitoring and Therapy
- Trigeminal Neuralgia and Treatments
- Sympathectomy and Hyperhidrosis Treatments
- Cardiac pacing and defibrillation studies
- Acute Ischemic Stroke Management
- Heart Rate Variability and Autonomic Control
- Cardiac Ischemia and Reperfusion
- Venous Thromboembolism Diagnosis and Management
- Cardiac, Anesthesia and Surgical Outcomes
- Acute Kidney Injury Research
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
Rigshospitalet
2017-2025
Copenhagen University Hospital
2018-2025
University of Copenhagen
2017-2024
Gentofte Hospital
2022
Glostrup Hospital
2018-2019
Hvidovre Hospital
2018
The appropriate oxygenation target for mechanical ventilation in comatose survivors of out-of-hospital cardiac arrest is unknown.In this randomized trial with a 2-by-2 factorial design, we randomly assigned adults 1:1 ratio to either restrictive oxygen partial pressure arterial (Pao2) 9 10 kPa (68 75 mm Hg) or liberal Pao2 13 14 (98 105 Hg); patients were also one two blood-pressure targets (reported separately). primary outcome was composite death from any cause hospital discharge severe...
Evidence to support the choice of blood-pressure targets for treatment comatose survivors out-of-hospital cardiac arrest who are receiving intensive care is limited.
Signaling molecule calcitonin gene-related peptide (CGRP) induces migraine attacks and anti-CGRP medications abort prevent attacks. Whether CGRP provokes cluster headache is unknown.To determine whether in episodic active phase, remission chronic headache.A randomized, double-blind, placebo-controlled, 2-way crossover study set at the Danish Headache Center, Rigshospitalet Glostrup, Denmark. Analyses were intent to treat. Inclusion took place from December 2015 April 2017. criteria diagnosis...
Guidelines recommend active fever prevention for 72 hours after cardiac arrest. Data from randomized clinical trials of this intervention have been lacking.
Abstract Background Following resuscitated out-of-hospital cardiac arrest (OHCA), inflammatory markers are significantly elevated and associated with hemodynamic instability organ dysfunction. Vasopressor support is recommended to maintain a mean arterial pressure (MAP) above 65 mmHg. Glucocorticoids have anti-inflammatory effects may lower the need for vasopressors. This study aimed assess of prehospital high-dose glucocorticoid treatment in comatose OHCA patients. Methods The STEROHCA...
Objective To investigate the role of calcitonin gene-related peptide, pituitary adenylate cyclase-activating polypeptide-38 (PACAP38) and vasoactive intestinal polypeptide in cluster headache, we measured these peptides interictally during experimentally induced headache attacks. Methods We included patients with episodic an active phase (n = 9), remission 9) chronic 13). Cluster attacks were by infusion peptide (1.5 µg/min) a randomized, double-blind, placebo controlled, two-way cross-over...
Patients who are successfully resuscitated following out-of-hospital cardiac arrest (OHCA) still at a high risk of neurological damage and death. Inflammation brain injury components the post-cardiac syndrome, can be assessed by systemic interleukin 6 (IL-6) neuron-specific enolase (NSE). Anti-inflammatory treatment with methylprednisolone may dampen inflammation, thereby improving outcome. This study aimed to determine if prehospital high-dose could reduce IL-6 NSE in comatose OHCA...
Background: In the Danish–German Cardiogenic Shock (DanGer Shock) trial, use of a microaxial flow pump (mAFP) in patients with ST-segment elevation myocardial infarction (STEMI)-related CS led to lower all-cause mortality but higher rates renal replacement therapy (RRT). this prespecified analysis, and predictors acute kidney injury (AKI) RRT were assessed. Methods: international, randomized, open label, multicenter 355 adult STEMI-CS randomized mAFP (N=179) or standard care alone (N=176)....
In patients with ST-segment elevation myocardial infarction (STEMI), acute inflammation is related to the extent of damage and may increase infarct size. Thus, administration pulse-dose glucocorticoid in very early phase reduce
Microvascular injury in patients with ST-segment elevation myocardial infarction (STEMI) occurs up to 50%, yet no therapeutic target exists. Inflammation contributes directly damage STEMI and may also cause deleteriously effects on the microcirculation. The aim of this prespecified sub-study was determine effect prehospital pulse-dose glucocorticoid microcirculation determined by index microvascular resistance (IMR) its relation inflammation. PULSE-MI trial a 1:1 randomized, blinded,...
Introduction In contrast to the premonitory phase of migraine, little is known about pre-attack (prodromal) a cluster headache. We aimed describe nature, prevalence, and duration symptoms in Methods Eighty patients with episodic headache or chronic headache, according ICHD-3 beta criteria, were invited participate. this observational study, underwent semi-structured interview where they asked presence 31 symptoms/signs relation typical attack. Symptoms included previously reported symptoms,...
To describe the nature, prevalence, and duration of symptoms in preictal, ictal, postictal phases cluster headache (CH) attacks.Fifty-seven patients with episodic or chronic CH participated this prospective, observational study. In a questionnaire concerning 33 migraine-related symptoms, reported clinical features up to 10 attacks/patient. The was divided into 3 sections: preictal phase, ictal phase. For each documented whether given symptom present, if possible estimated symptom.In total,...
BackgroundOut-of-hospital cardiac arrest (OHCA) survivors remaining comatose are often circulatory unstable with high mortality in the first days following resuscitation. Elevated lactate will reflect severity and duration of hypoperfusion arrest. Further, could modify effect on survival different mean arterial blood pressure (MAP) targets.MethodsIn this sub-study BOX trial, adult successfully resuscitated OHCA patients (n = 789) a presumed cause were randomized to MAP target 63 mmHg vs. 77...
Abstract Background Acute kidney injury (AKI) is a significant risk factor associated with reduced survival following out-of-hospital cardiac arrest (OHCA). Whether the severity of AKI simply serves as surrogate measure worse peri-arrest conditions, or represents an additional to long-term remains unclear. Methods This sub-study derived from randomized trial in which 789 comatose adult OHCA patients presumed cause and sustained return spontaneous circulation (ROSC) were enrolled. Patients...
Abstract Background Venous return (VR) physiology may be elucidated using a calculated mean systemic filling pressure analogue ( P msa ) that reflects the stressed intravascular volume. The aim of this study was to explore differences in VR physiological variables with hypothesis vasopressor therapy targeting higher arterial (MAP) would associate an increased volume state. This important appreciate effect intervention traditionally is judged by response alone. Methods exploratory used data...
Abstract Aim To assess the association with outcomes of cardiac index (CI) and mixed venous oxygen saturation (SvO2) in comatose patients resuscitated from out-of-hospital arrest (OHCA). Methods In cohort study 789 included “BOX”-trial, 565 (77%) were this hemodynamic substudy (age 62 ± 13 years, male sex 81%). Pulmonary artery catheters inserted shortly after ICU admission. CI SvO2 measured as soon possible until awakening or death. The endpoints all-cause mortality at 1 year renal failure...
Abstract Background The “Blood Pressure and Oxygenation Targets in Post Resuscitation Care” (BOX) trial investigated whether a low versus high blood pressure target, restrictive liberal oxygenation shorter longer duration of device-based fever prevention comatose patients could improve outcomes. No differences rates discharge from hospital with severe disability or 90-day mortality were found. However, long-term effects potential interaction the interventions are unknown. Accordingly,...
BackgroundThe post-cardiac arrest syndrome (PCAS) after out-of-hospital cardiac (OHCA) is characterized by a series of pathological events, including inflammation. In the randomized "STERoid for OHCA" (STEROHCA) trial, prehospital high-dose glucocorticoid decreased interleukin (IL) 6 and C-reactive protein levels following resuscitated OHCA. The aim this predefined sub-study was to assess inflammatory response first three days admission.MethodsThe STEROHCA trial enrolled 137 OHCA patients...
Neutrophil gelatinase-associated lipocalin (NGAL) is an inflammatory biomarker related to acute kidney injury (AKI). Including 1892 consecutive patients with ST-elevation myocardial infarction (STEMI), in which NGAL was measured 1624 (86%) on admission and a subgroup at 6-12 h (n = 163) 12-24 222) after admission, this study aimed evaluate the prognostic value of predicting AKI mortality. Patients were stratified based whether their plasma concentration greater than or equal to/less median....
Background and purpose Cluster headache (CH) is characterized by severe, unilateral attacks of pain a high nocturnal attack burden. It remains unknown whether perturbations sleep are solely present during the CH bout. Therefore, we aimed to investigate differences in between bout remission period patients with episodic and, secondly, compare two phases controls. Methods Patients (aged 18–65 years), diagnosed according International Classification Headache Disorders 2nd edition, were admitted...
Targeted temperature management (TTM) may moderate the injury from out-of-hospital cardiac arrest. Slowing metabolism has been a suggested effect. Nevertheless, studies have found higher lactate levels in patients cooled to 33°C compared with 36°C even days TTM cessation. Larger not performed on TTM's effect metabolome. Accordingly, explore of TTM, we used ultra-performance liquid-mass spectrometry substudy 146 randomized trial either or for 24 hours and quantified 60 circulating metabolites...