A5070545719- Diabetes Treatment and Management
- Cardiovascular Function and Risk Factors
- Heart Failure Treatment and Management
- Diabetes Management and Research
- Advanced Glycation End Products research
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Diet and metabolism studies
- Diabetes and associated disorders
- Electrolyte and hormonal disorders
- Pregnancy and preeclampsia studies
- Blood Pressure and Hypertension Studies
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Chronic Kidney Disease and Diabetes
- Nitric Oxide and Endothelin Effects
- Cardiovascular Health and Disease Prevention
- Bone Metabolism and Diseases
- Gestational Diabetes Research and Management
- Metabolism, Diabetes, and Cancer
- Adipokines, Inflammation, and Metabolic Diseases
- Apelin-related biomedical research
- Diabetic Foot Ulcer Assessment and Management
- GDF15 and Related Biomarkers
- Heart rate and cardiovascular health
- Renin-Angiotensin System Studies
- Blood properties and coagulation
Regional Hospital Horsens
2024
Aarhus University Hospital
2014-2020
Aarhus University
2014-2020
Steno Diabetes Centers
2007-2017
Nordsjællands Hospital
2015
Rigshospitalet
2007
OBJECTIVE To investigate the associations of plasma levels advanced glycation end products (AGEs) with incident cardiovascular disease (CVD) and all-cause mortality in type 1 diabetes extent to which any such could be explained by endothelial renal dysfunction, low-grade inflammation, arterial stiffness. RESEARCH DESIGN AND METHODS We prospectively followed 169 individuals diabetic nephropathy 170 persistent normoalbuminuria who were free CVD at study entry whom Nε-(carboxymethyl)lysine,...
Trimethylamine N-oxide (TMAO) is suggested as an independent gut microbiota-derived risk factor for cardiovascular and renal disease. We investigated associations between plasma TMAO concentrations cardio-renal outcomes in a prospective study of individuals with type 1 diabetes.Plasma was measured at baseline 1,159 diabetes (58% male, mean ± SD age 46 13 years). End points were all-cause mortality, disease (CVD), events tracked from national registries. Associations end tested using Cox...
To investigate whether circulating asymmetric dimethylarginine (ADMA) levels are predictive of cardiovascular events, decline in glomerular filtration rate (GFR), end-stage renal disease (ESRD), and all-cause mortality type 1 diabetic patients.We performed a prospective observational follow-up study including 397 patients with overt nephropathy (243 men aged 42.1 +/- 10.5 years, GFR 76 34 ml/min per 1.73 m(2)) control group 175 longstanding diabetes persistent normoalbuminuria (104 42.7 9.7...
Growth deferentiation factor-15 (GDF-15) is involved in inflammation and apoptosis. Expression induced the heart response to ischemia atherosclerotic plaques. The aim of this study was investigate GDF-15 levels relation all-cause mortality, cardiovascular mortality morbidity, decline glomerular filtration rate (GFR), progression toward end-stage renal disease (ESRD).The a prospective observational follow-up including 451 type 1 diabetic patients with nephropathy (274 men, aged 42.1 +/- 0.5...
OBJECTIVE To investigate the associations of plasma levels soluble receptor for advanced glycation end products (sRAGE) with incident cardiovascular disease (CVD) and all-cause mortality in type 1 diabetes extent to which any such could be explained by endothelial renal dysfunction, low-grade inflammation, arterial stiffness, (AGEs). RESEARCH DESIGN AND METHODS We prospectively followed 169 individuals diabetic nephropathy 170 persistent normoalbuminuria who were free CVD at study entry whom...
We evaluated the predictive value of baseline plasma connective tissue growth factor (CTGF) in a prospective study patients with type 1 diabetes.Subjects were 198 diabetic established nephropathy and 188 persistent normoalbuminuria. Follow-up time was 12.8 years. Prediction end-stage renal disease (ESRD) mortality by CTGF analyzed conjunction conventional risk factors.Plasma higher than normoalbuminuria (median 381 [interquartile range 270-630] vs. 235 [168-353] pmol/l). In nephropathy,...
It has been suggested that genetic susceptibility plays an important role in the pathogenesis of diabetic nephropathy. A large-scale genotyping analysis gene-based single nucleotide polymorphisms (SNPs) Japanese patients with type 2 diabetes identified gene encoding acetyl-coenzyme carboxylase beta (ACACB) as a candidate for to nephropathy; landmark SNP was found intron 18 ACACB (rs2268388: +4139 C > T, p = 1.4×10−6, odds ratio 1.61, 95% confidence interval [CI]: 1.33–1.96). The association...
Methylglyoxal (MGO), a major precursor for advanced glycation end products, is increased in diabetes. In diabetic rodents, inhibition of MGO prevents cardiovascular disease (CVD). Whether plasma levels are associated with incident CVD people type 1 diabetes unknown. We included 159 individuals persistent normoalbuminuria and 162 nephropathy (DN) from the outpatient clinic at Steno Diabetes Center. measured baseline recorded fatal nonfatal over median follow-up 12.3 years (interquartile range...
Altered regulation of extracellular matrix remodeling by metalloproteinases (MMPs) and tissue inhibitor metalloproteinase (TIMP) may contribute to vascular complications in type 1 diabetes. We investigated associations between plasma MMP-1, -2, -3, -9, -10 TIMP-1, cardiovascular events all-cause mortality diabetic patients.We prospectively followed 337 patients [mean age 41.4 years (9.6), 39% female], 170 with 167 without nephropathy, median follow-up 12.3 years. Survival analyses were...
Abstract Aims In patients with chronic heart failure reduced ejection fraction (HFrEF), myocardial ketone metabolism is increased and short‐term treatment the body 3‐hydroxy butyrate (3‐OHB) has beneficial haemodynamic effects. HFrEF, we investigated whether level of circulating 3‐OHB predicted all‐cause mortality sought to identify correlations between patient characteristics levels. Methods results We conducted a cohort study in 218 HFrEF. Plasma levels were measured using high‐performance...
Type 1 diabetes (T1D) is characterized by an increased risk of macrovascular complications. Pregnancy-associated plasma protein-A (PAPP-A) generated N- and C-terminal fragments IGF binding protein-4 (NT-IGFBP-4 CT-IGFBP-4) have been suggested as cardiac biomarkers.The objective the study was to investigate prognostic value IGFBP-4 in a cohort T1D patients.We prospectively followed up 178 patients with diabetic nephropathy 152 normoalbuminuria for 12.6 (range 0.2-12.9) years.Levels IGF-1,...
Altered regulation of extracellular matrix (ECM) composition by metalloproteinases (MMPs) and tissue inhibitors metalloproteinase (TIMPs) may contribute to arterial stiffening. We investigated associations between circulating MMP-1, -2, -3, -9, -10 TIMP-1, carotid-femoral pulse wave velocity (cfPWV) pressure (PP), as markers stiffness in type 1 diabetic patients.Individuals with diabetes from three different cohorts were included this study: EURODIAB Prospective Complications study (n =...
Diabet. Med. 29, 990–994 (2012) Abstract Aims To evaluate whether pulse pressure alone or with placental growth factor as estimates of arterial stiffness and endothelial dysfunction, predicts mortality, cardiovascular disease progression to end‐stage renal in patients Type 1 diabetes. Methods Prospective, observational study, median (range) follow‐up 8 (0–13) years, 900 diabetes, 458 diabetic nephropathy, mean ± SD age 44 11 years. Results During follow‐up, we recorded 178 (20%) all‐cause...
Introduction Heart failure is one of the most common cardiovascular complications diabetes and disabling deadly complication too. Many antidiabetic agents have been associated with increased morbidity mortality in a subset patients chronic heart (CHF); thus, new treatment modalities are warranted. Interestingly, beneficial effect incretin hormone, GLP-1, on cardiac function has suggested without diabetes. Liraglutide (Victoza) GLP-1 analogue developed for type 2 (T2D); however, its impact...