A5010064968- Advanced MRI Techniques and Applications
- Advanced NMR Techniques and Applications
- Atomic and Subatomic Physics Research
- Diabetes Treatment and Management
- Electron Spin Resonance Studies
- Heart Failure Treatment and Management
- Lanthanide and Transition Metal Complexes
- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Electrolyte and hormonal disorders
- Effects of Radiation Exposure
- Pediatric Urology and Nephrology Studies
- Heart rate and cardiovascular health
- Acute Kidney Injury Research
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Systemic Lupus Erythematosus Research
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
- Vasculitis and related conditions
- Solid-state spectroscopy and crystallography
- Cardiovascular Syncope and Autonomic Disorders
- Cardiac electrophysiology and arrhythmias
- Renal function and acid-base balance
- Autoimmune Bullous Skin Diseases
- Cardiac Imaging and Diagnostics
Aarhus University Hospital
2013-2024
Aarhus University
2016-2023
Regional Hospital Horsens
2021
RELX Group (United States)
2020
International Society of Nephrology
2020
Hyperpolarised MRI with Dynamic Nuclear Polarisation overcomes the fundamental thermodynamic limitations of conventional magnetic resonance, and is translating to human studies several early-phase clinical trials in progress including early reports that demonstrate utility technique observe lactate production brain cancer patients. Owing coupling metabolism tissue function, metabolic neuroimaging hyperpolarised [1-
Abstract Myocardial deformation assessed by speckle tracking echocardiography (STE) is increasingly used for diagnosis, monitoring and prognosis in patients with clinical pre-clinical cardiovascular diseases. Feature cardiac magnetic resonance (FT-CMR) also allows myocardial analysis. To clarify whether the two modalities can be interchangeably, we compared analysis FT-CMR STE a variety of diseases healthy subjects. We included 40 10 subjects undergoing echocardiographic examination left...
Contact force (CF) between radiofrequency (RF) ablation catheter and myocardium index (AI) correlates with RF lesion depth width in normal-voltage (>1.5 mV) (NVM). We investigate the impact of CF on low (<0.5 (LVM) intermediate-voltage (0.5-1.5 (IVM) following myocardial infarction. Correlation evaluated by native contrast magnetic resonance imaging (ncMRI) gross anatomical evaluation was investigated.Twelve weeks after infarction, 10 pigs underwent electroanatomical mapping endocardial...
Calibration of hyperpolarized
"Large-vessel giant cell arteritis after COVID-19 vaccine." Scandinavian Journal of Rheumatology, 51(2), pp. 154–155 AcknowledgementsThe initial draft was written by AM. All authors contributed with clinical and radiological data for the patient, reviewed article, participated in editing, approved final version manuscript. The patient mentioned this case report shown manuscript before publication, informed consent obtained.No specific funding received from any bodies public, commercial or...
Purpose To study hyperpolarized water as an angiography and perfusion tracer in a large animal model. Methods Protons dissolved deuterium oxide (D 2 O) were SPINlab dissolution dynamic nuclear polarization (dDNP) polarizer subsequently investigated vivo pig model at 3 Tesla (T). Approximately 15 mL of was injected the renal artery by hand over 4–5 s. Results A liquid state 5.3 ± 0.9% 3.8 M protons achieved with T 1 24 This allowed injection through arterial catheter into high‐contrast...
Sodium magnetic resonance imaging (MRI) is a powerful, non-invasive technique to assess sodium distribution within the kidney. Here we undertook pre-clinical and clinical studies quantify corticomedullary gradient in healthy individuals porcine model of diuresis. The results demonstrated that MRI could detect spatial differences biodistribution across kidney changed significantly after diuresis pig was independent blood electrolyte measurements. Thus, rapid can be used dynamically human
To assess the effect of liraglutide, a glucagon-like peptide-1 receptor agonist, on urinary sodium excretion as well circulating adrenomedullin and copeptin levels in patients with type 2 diabetes (T2D).In LIVE study, (n = 241) left ventricular ejection fraction ≤45% were randomized to liraglutide 1.8 mg daily or placebo for 24 weeks, 30% had concomitant diagnosis T2D. Plasma N-terminal brain-natriuretic-peptide (NT-proBNP) (a predefined secondary endpoint), midregional...
Purpose To investigate dynamic coronary MR angiography using hyperpolarized water as a positive contrast agent. Hyperpolarization can increase the signal by several orders of magnitude, and has recently been translated to human cardiac application. The aim was achieve large 1 H enhancement allow high‐resolution imaging arteries. Methods Protons in D 2 O were dissolution nuclear polarization. A total 18 mL injected into arteries healthy pigs ( N = 9; 3 injections animals). MRI images acquired...
Cardiac metabolism has received considerable attention in terms of both diagnostics and prognostics, as well a novel target for treatment. As human trials involving hyperpolarized magnetic resonance the heart are imminent, we sought to evaluate general feasibility detection an imposed shift metabolic substrate utilization during modulation with glucose–insulin–potassium (GIK) infusion, thus limitations associated this strategy, large animal model resembling physiology. Four [1‐ 13 C]pyruvate...
Hyperpolarized [1-
Introduction of hyperpolarized magnetic resonance in preclinical studies and lately translation to patients provides new detailed vivo information metabolic flux organs. Hyperpolarized based on 13C enriched pyruvate is performed without ionizing radiation allows quantification the conversion products: alanine, lactate bicarbonate real time. Thus, this methodology has a promising potential for monitoring energetic alterations hepatic diseases. Using pyruvate, we investigated metabolism...
Purpose Deranged metabolism is now recognized as a key causal factor in variety of heart diseases, and being studied extensively. However, invasive methods may alter metabolism, conventional imaging techniques measure tracer uptake but not downstream metabolism. These challenges be overcome by hyperpolarized MR, noninvasive technique currently crossing the threshold into human trials. The aim this study was to image metabolic changes response endogastric glucose bolus acute hypertension....
Purpose Owing to its noninvasive nature, hyperpolarized MRI may improve delineation of myocardial metabolic derangement in heart disease. However, consistency depend on the changeable nature cardiac metabolism relation whole‐body state. This study investigates impact feeding status a large animal model resembling human physiology. Methods Thirteen 30‐kg pigs were subjected an overnight fast, and 5 fed carbohydrate‐rich meal morning experiments. Vital parameters blood samples registered. All...
Background. Liraglutide, a glucagon-like peptide-1 agonist, is used for treatment of type 2 diabetes and has beneficial cardiovascular properties. However, increases heart rate (HR) possibly the risk events in chronic failure (CHF) patients. We investigated potential associations between HR changes clinical, laboratory echocardiographic parameters clinical liraglutide treated CHF Methods. This was sub-study LIVE study. patients (N = 241) with left ventricular ejection fraction ≤45% were...
Renal ischemia‐reperfusion injury (IRI) is one of the most common types acute kidney injury. Spironolactone has shown promising protective effects in renal IRI rats. We investigated hemodynamic and metabolic spironolactone (100 mg/kg) administered immediately after 40 min unilateral ischemia Hyperpolarized MRI using co‐polarized [1‐ 13 C]pyruvate [ C, 15 N 2 ]urea as well 1 H dynamic contrast‐enhanced (DCE) was performed 24 h induction ischemia. found a significant decrease blood flow (RBF)...
Purpose Ischemic injury in the kidney is a common pathophysiological event associated with both acute and chronic disease; however, regional ischemia–reperfusion as seen thromboembolic renal disease often undetectable thus subclinical. Here, we assessed metabolic alterations following subclinical focal hyperpolarized [1‐ 13 C]pyruvate MRI porcine model. Methods Five pigs were subjected to 60 min of ischemia. After 90 reperfusion, multiparametric proton protocol was performed on clinical 3T...
Background and Aims: Chronic radiation proctitis is a disease associated with radiotherapy of cancer in the pelvic region. The main symptom rectal bleeding. Several treatment modalities have been attempted, but few demonstrated satisfactory effects. We present our experience formalin applied locally to mucosa chronic proctitis. Furthermore, we assess possible complications, gravest suggested being cancer. Previous studies on subject reported good results, often somewhat vaguely defined...
Purpose Hyperpolarized [1‐ 13 C]pyruvate MRS can measure cardiac metabolism in vivo. We investigated whether could predict left ventricular remodeling following myocardial infarction (MI), long‐term effects of heart failure medication, and identify responders to treatment. Methods Thirty‐five rats were scanned with hyperpolarized 3 days after MI or sham surgery. The animals re‐examined 30 therapy β‐blockers ACE‐inhibitors (active group, n = 12), placebo treatment (placebo 13) no (sham 10)....
What is the central question of this study? Is it possible to combine hyperpolarized magnetic resonance technique and hyperinsulinaemic clamp method in order evaluate skeletal muscle metabolism a large animal model? main finding its importance? The logistical set-up possible, we found substantial increments glucose infusion rates representing uptake but no differences ratios [1-13 C]lactate C]pyruvate, C]alanine 13 C-bicarbonate implying that hyperpolarization might not be optimal for...
Methods: Using the 2004-2013 National Inpatient Sample, largest publicly available inpatient care database representing more than 95% of United States population, we extracted data using ICD 9 code 410.7 (NSTEMI) as primary diagnosis and 585 (CKD) secondary diagnosis.We excluded patients with missing information on age, sex, mortality for a final sample size 3,784,774.We used multilevel logistic linear regression models random effect to adjust confounding.Results: Among 3,784,774 admissions...