A5101809316- Cardiovascular Function and Risk Factors
- Cardiac Arrhythmias and Treatments
- Cardiac pacing and defibrillation studies
- Pulmonary Hypertension Research and Treatments
- Atrial Fibrillation Management and Outcomes
- Cardiac electrophysiology and arrhythmias
- Physiological and biochemical adaptations
- Cardiomyopathy and Myosin Studies
- Congenital heart defects research
- Cardiac Imaging and Diagnostics
- Heart Failure Treatment and Management
- Advanced MRI Techniques and Applications
- Cardiac Arrest and Resuscitation
- Cardiac Ischemia and Reperfusion
- Coronary Artery Anomalies
- Advanced Glycation End Products research
- Infrared Thermography in Medicine
- Cardiovascular Disease and Adiposity
- Cardiovascular Issues in Pregnancy
- Bat Biology and Ecology Studies
- Lipid metabolism and biosynthesis
- Chronic Disease Management Strategies
- Antimicrobial Peptides and Activities
- Cardiovascular Syncope and Autonomic Disorders
- Tendon Structure and Treatment
Aarhus University Hospital
2009-2025
Aarhus University
2013-2025
Odense University Hospital
2024
E Ink (South Korea)
2013
University of California, Los Angeles
2001
Beth Israel Deaconess Medical Center
2001
Tufts University
2001
University of Minnesota
2001
Duke Institute for Health Innovation
2001
University of North Carolina at Chapel Hill
2001
The multiple convergent evolution of high systemic blood pressure among terrestrial vertebrates has always been accompanied by lowered pulmonary pressure. In mammals, birds and crocodilians, this cardiac separation pressures relies on the complete division right left ventricles a ventricular septum. However, anatomy ventricle most reptiles does not allow for anatomical division, but hearts pythons varanid lizards can produce while keeping low. It is also known that these two groups are...
Abstract Conduction system pacing (CSP) is being increasingly adopted as a more physiological alternative to right ventricular and biventricular pacing. Since the 2021 European Society of Cardiology guidelines, there has been growing evidence that this therapy safe effective. Furthermore, left bundle branch area was not covered in these guidelines due limited at time. This Clinical Consensus Statement provides advice on indications for CSP, taking into account significant evolution domain.
Abstract Up to one third of patients referred for transcatheter tricuspid valve intervention (TTVI) have a transvalvular pacemaker (PPM) or implantable cardioverter-defibrillator (ICD) lead in place. Both the electrophysiology and interventional cardiology communities been alerted complexity decision making this situation due potential interactions between leads TTVI material, including risk jailing damage leads. This document, commissioned by European Heart Rhythm Association (EHRA)...
Visceral hyperalgesia is most likely a phenomenon of substantial clinical importance and may also play role in the pathophysiology irritable bowel syndrome (IBS). We investigated manifestation visceral IBS patients by nociceptive electric stimulation rectosigmoid junction rectum.Twelve fulfilling Rome criteria 9 healthy controls were studied. single repeated burst stimuli applied with bipolar stimulator inserted through sigmoidoscope. The sensation (ST) pain detection (PDT) thresholds...
Mammals evolved from reptile-like ancestors, and while the mammalian heart is driven by a distinct sinus node, node not apparent in reptiles. We characterized myocardial systemic venous pole, venosus, reptiles to identify dominant pacemaker assess whether venosus remodels adopts an atrium-like phenotype as observed mammals. Anolis lizards had extensive of myocardium expressing Tbx18. A small sub-population cells encircling sinuatrial junction expressed Isl1, Bmp2, Tbx3, Hcn4, homologues...
Obesity causes lipid accumulation in the heart and may lead to lipotoxic disease. Traditionally, size of cardiac triglyceride pool is thought reflect balance between uptake beta-oxidation fatty acids. However, triglycerides can also be exported from cardiomyocytes via secretion apolipoproteinB-containing (apoB) lipoproteins. Lipoprotein formation depends on expression microsomal transfer protein (MTP); mouse expresses two isoforms MTP, A B. Since many aspects link obesity-induced disease...
Pulmonary arterial hypertension (PAH) is a fatal disease, and the ultimate cause of death right ventricular (RV) failure. In this study, we investigated acute hemodynamic effects levosimendan in two rat models RV hypertrophy Wistar rats were randomized to receive sham surgery (n = 8), pulmonary trunk banding (PTB; n or monocrotaline injection (MCT; 7). function was evaluated at baseline after placebo concentrations (12 60 μg/kg) using magnetic resonance imaging, echocardiography, invasive...
ABSTRACT Among lizards, only monitor lizards (Varanidae) have a functionally divided cardiac ventricle. The division results from the combined function of three partial septa, which may be homologous to ventricular septum mammals and archosaurs. We show in developing monitors that two ‘muscular ridge’ ‘bulbuslamelle’, express evolutionarily conserved transcription factors Tbx5, Irx1 Irx2, orthologues mark mammalian septum. Compaction embryonic trabeculae contributes formation these septa....
Background: We investigated if soluble guanylate cyclase stimulation either alone or in combination with phosphodiesterase-5 (PDE5) inhibition could prevent pressure overload–induced right ventricular (RV) hypertrophy and failure. Methods: The stimulator BAY 41-2272 (BAY, 10 mg·kg−1·d−1) (BAY + SIL) a PDE5 inhibitor sildenafil (SIL, 100 was examined for prevention of RV failure Wistar rats (n = 73) operated by pulmonary trunk banding. Results: All treatments failed to inhibit the development...
Abstract Background Malignant arrhythmias are a major cause of sudden cardiac death in adults with congenital heart disease. We developed model to serially investigate electrophysiological properties an animal right ventricular hypertrophy and failure. Method created models compensated (cHF; n=11) decompensated (dHF; failure Wistar rats by pulmonary trunk banding. Healthy controls underwent sham operation (Control; n=13). Surface electrocardiography was recorded from extremities,...
Right heart function is an important predictor of morbidity and mortality in patients suffering from pulmonary arterial hypertension congenital diseases. We investigated whether the prostacyclin analog iloprost has a direct inotropic effect pressure-overloaded hypertrophic dysfunctional right ventricle (RV). Rats were randomized to monocrotaline injection (60 mg/kg; [Formula: see text]), trunk banding (PTB; or sham operation ([Formula: text]). RV was evaluated with magnetic resonance...
Background: We investigated if chronic levosimendan treatment can prevent and revert pressure-overload–induced right ventricular hypertrophy failure in rats. Methods: Right was induced Wistar rats by pulmonary trunk banding (PTB). The PTB were treated with (3 mg·kg−1·d−1) 3 days before surgery [n = 10, prevention (PREV)], weeks after reversal (REV)] or vehicle (n VEH). Sham-operated received 16, SHAM). function evaluated 7 echocardiography, magnetic resonance imaging, pressure–volume...
Cell-based regenerative therapy may be useful for treatment of acute myocardial infarction (AMI). Animal xenograft models are ideally suited preclinical studies evaluating prospective regimes, identifying candidate human cell populations, and gaining mechanistic insight. Here we address whether the athymic nude rat is suitable as a model study CD34+ mobilized peripheral blood stem cells (M-PBSCs) in repair AMI. We injected donor into infarct border rats with surgically induced AMI evaluated...
The purpose of this study was to investigate whether acute intravenous administration the phosphodiesterase type 5 (PDE‐5) inhibitor sildenafil in a single clinically relevant dose improves vivo function hypertrophic and failing right ventricle (RV). Wistar rats ( n = 24) were subjected pulmonary trunk banding (PTB) causing RV hypertrophy failure. Four weeks after surgery, they randomized receive an bolus (1 mg/kg; 7), vehicle 6), or dobutamine (10 μg/kg; 6). Invasive pressures recorded...