A5027053179- Venous Thromboembolism Diagnosis and Management
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Function and Risk Factors
- Atrial Fibrillation Management and Outcomes
- Cardiac Arrhythmias and Treatments
- Ultrasound in Clinical Applications
- Acute Ischemic Stroke Management
- Heart Failure Treatment and Management
- Sepsis Diagnosis and Treatment
- Central Venous Catheters and Hemodialysis
- Hemodynamic Monitoring and Therapy
- Cardiovascular Effects of Exercise
- Psychology, Coaching, and Therapy
- Acute Myocardial Infarction Research
- Congenital Heart Disease Studies
- Mechanical Circulatory Support Devices
- Artificial Intelligence in Healthcare and Education
- Sports injuries and prevention
- Clinical Laboratory Practices and Quality Control
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Cardiac Structural Anomalies and Repair
- Health and Medical Studies
- Diet and metabolism studies
- Antibiotic Use and Resistance
- Psychoanalysis and Social Critique
Aarhus University Hospital
2014-2024
Aarhus University
2018-2024
University of Louisville
2019-2024
Neurological Surgery
2024
Massachusetts General Hospital
2019-2021
Harvard University
2021
Universidade Federal do Piauí
2020
Aalborg University Hospital
2020
Indiana University – Purdue University Indianapolis
2018
Western Michigan University
2018
The purpose of this study was to determine the relative contribution fibrosis-mediated and myofibril-mediated stiffness in rats with mild severe right ventricular (RV) dysfunction.By performing pulmonary artery banding different diameters for 7 weeks, RV dysfunction (Ø=0.6 mm) (Ø=0.5 were induced rats. fibrosis- determined trabecular strips. Total myocardial increased trabeculae from both comparison controls. In dysfunction, explained by stiffness, whereas only control. Histological analyses...
Background We provide the first multicenter analysis of patients cared for by eight Pulmonary Embolism Response Teams (PERTs) in United States (US); describing frequency team activation, patient characteristics, pulmonary embolism (PE) severity, treatments delivered, and outcomes. Methods enrolled from National PERT Consortium™ registry with a activation between 18 October 2016 17 2017. Data are presented combined institution. Differences institutions were analyzed using chi‐squared test or...
Significant biomechanical differences were found among deadlift variations. However, little is known about the between conventional and Romanian deadlifts. Therefore, purpose of this study was to determine which technique a better training protocol deadlifts as indicated by greater demand in muscle activities joint kinetics.21 males performed each with 70% one repetition maximum (1RM) determined using 1RM testing. Myoelectric rectus femoris, biceps gluteus maximus lower extremity net torque...
Abstract Background The haemodynamic response following acute, intermediate-risk pulmonary embolism is not well described. We aimed to describe the cardiovascular changes in initial, critical phase 0–12 hours after acute an in-vivo porcine model. Methods Pigs were randomly allocated (n = 6) or sham 6). Pulmonary was administered as autologous blood clots (20 × 1 cm) until doubling of mean arterial pressure greater than 34 mmHg. Sham animals received saline. Cardiopulmonary evaluated for 12...
Acute pulmonary embolism (PE) is the third most common cardiovascular cause of death after acute myocardial infarction and stroke. Patients are, however, often under‐treated due to risks associated with systemic thrombolysis surgical embolectomy. Novel pharmacological catheter‐based treatment strategies show promise, but data supporting their use in patients are sparse. We therefore aimed develop an vivo model PE enabling controlled evaluations efficacy safety novel therapies. Danish...
Right ventricular (RV) failure induced by sustained pressure overload is a major contributor to morbidity and mortality in several cardiopulmonary disorders. Reliable reproducible animal models of RV are therefore warranted order investigate disease mechanisms effects potential therapeutic strategies. Banding the pulmonary trunk common method induce isolated hypertrophy but general, previously described have not succeeded creating stable model failure. We present rat caused banding (PTB)...
Acute pulmonary embolism is a frequent condition in emergency medicine and potentially fatal. Cause of death right ventricular failure due to increased afterload from both vascular obstruction vasoconstriction. Inodilators are interesting drugs choice as they may improve function lower its afterload. We aimed investigate the cardiovascular effects three clinically relevant inodilators: levosimendan, milrinone, dobutamine acute embolism. conducted randomized, blinded, animal study using 18...
We investigated whether chronic levosimendan treatment can prevent and revert right ventricular (RV) failure attenuate pulmonary vascular remodeling in a rat model of arterial hypertension (PAH).PAH was induced rats by exposure to SU5416 hypoxia (SuHx). The were randomized (3 mg·kg·d) initiated before SuHx (n = 10, PREV), started 6 weeks after 12, REV), or vehicle VEH). Healthy control received CONT). Ten SuHx, RV function evaluated echocardiography, magnetic resonance imaging, invasive...
Background: Pulmonary vasodilators as add-on to current treatment strategies in acute pulmonary embolism may improve right ventricular unloading and hence patient outcome. We aimed investigate whether stimulation of the nitric oxide (NO)–soluble guanylate cyclase (sGC)–cyclic guanosine monophosphate (cGMP) pathway with riociguat, sildenafil or inhaled NO causes vasodilation improves function a porcine model intermediate risk embolism. Methods: Two large autologous blood clots were...
Abstract Background To investigate if acute pulmonary vasodilation by sildenafil improves right ventricular function in patients with intermediate-high risk embolism (PE). Methods Single center, explorative trial. Patients PE were randomized to a single oral dose of 50 mg (n = 10) or placebo as add-on conventional therapy. The time from hospital admission study inclusion was 2.3 ± 0.7 days. Right evaluated immediately before and shortly after (0.5–1.5 h) randomization heart catheterization...
Abstract Background Acute pulmonary embolism (PE) induces ventilation-perfusion mismatch and hypoxia increases pressure right ventricular (RV) afterload, entailing potentially fatal RV failure within a short timeframe. Cardiopulmonary factors may respond differently to increased clot burden. We aimed elucidate immediate cardiopulmonary responses during successive PE episodes in porcine model. Methods This was randomized, controlled, blinded study of repeated measurements. Twelve pigs were...
Abstract Background Malignant arrhythmias are a major cause of sudden cardiac death in adults with congenital heart disease. We developed model to serially investigate electrophysiological properties an animal right ventricular hypertrophy and failure. Method created models compensated (cHF; n=11) decompensated (dHF; failure Wistar rats by pulmonary trunk banding. Healthy controls underwent sham operation (Control; n=13). Surface electrocardiography was recorded from extremities,...
We investigated whether the vasopressin-analog, terlipressin induces systemic vasoconstriction and pulmonary vasodilation in a porcine model of acute embolism.
Abstract Background Inhaled nitric oxide (iNO) effectively reduces right ventricular afterload when administered in the immediate phase of acute pulmonary embolism (PE) preclinical animal models. In a porcine model intermediate-risk PE, we aimed to investigate whether iNO has vasodilator efficacy both and prolonged PE. Methods Anesthetized pigs (n = 18) were randomized into three subgroups. An PE iNO-group 6) received at 40 ppm one, three, six, nine 12 hours after onset Vehicle animals but...
Objectives: To compare the hemodynamic effects of increased versus decreased preload in a porcine model acute intermediate-risk pulmonary embolism. Design: Randomized, controlled animal study. Setting: Tertiary medical center, research laboratory. Subjects: Female, Danish slaughter pigs ( n = 22, ~ 60 kg). Interventions: Acute embolism was induced by large emboli made from clotting autologous blood. Sixteen animals were randomized to either fluid loading 8, isotonic saline, 1 L/hr for 2 hr)...