A5078399312- Venous Thromboembolism Diagnosis and Management
- Acute Ischemic Stroke Management
- Acute Myocardial Infarction Research
- Atrial Fibrillation Management and Outcomes
- Coronary Interventions and Diagnostics
- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Central Venous Catheters and Hemodialysis
- Cardiac Imaging and Diagnostics
- Cardiac Structural Anomalies and Repair
- Ultrasound in Clinical Applications
- Renal Transplantation Outcomes and Treatments
- Diagnosis and Treatment of Venous Diseases
- Antiplatelet Therapy and Cardiovascular Diseases
- Peripheral Artery Disease Management
- Pulmonary Hypertension Research and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- Cardiac Valve Diseases and Treatments
- Sepsis Diagnosis and Treatment
- Erythropoietin and Anemia Treatment
- Organ Transplantation Techniques and Outcomes
- Blood transfusion and management
- Vascular Procedures and Complications
- Machine Learning in Healthcare
- Blood donation and transfusion practices
University of Pennsylvania
2014-2024
Penn Presbyterian Medical Center
2014-2024
Penn Center for AIDS Research
2019-2024
University of Pennsylvania Health System
2019-2022
Hospital of the University of Pennsylvania
2018-2022
Pennsylvania Hospital
2022
University of Pittsburgh Medical Center
2011-2019
University of Pittsburgh
2007-2014
The aim of this study was to evaluate the safety and effectiveness percutaneous mechanical thrombectomy using FlowTriever System (Inari Medical, Irvine, California) in a prospective trial patients with acute intermediate-risk pulmonary embolism (PE). Catheter-directed thrombolysis has been shown improve right ventricular (RV) function PE. However, catheter-directed increases bleeding risk many PE have relative absolute contraindications thrombolysis. Patients symptomatic, computed...
Evidence supporting interventional pulmonary embolism (PE) treatment is needed.
Hemodynamically unstable high-risk, or massive, pulmonary embolism (PE) has a reported in-hospital mortality of over 25%. Systemic thrombolysis is the guideline-recommended treatment despite limited evidence. The FLAME study (FlowTriever for Acute Massive PE) was designed to generate evidence interventional treatments in high-risk PE.
Abstract Objectives The FlowTriever All‐Comer Registry for Patient Safety and Hemodynamics (FLASH) is a prospective multi‐center registry evaluating the safety effectiveness of percutaneous mechanical thrombectomy treatment pulmonary embolism (PE) in real‐world patient population (NCT03761173). This interim analysis reports outcomes first 250 patients enrolled FLASH. Background High‐ intermediate‐risk PEs are characterized by high mortality rates, frequent readmissions, long‐term sequelae....
Patients with acute pulmonary embolism (PE) and hypotension (high-risk PE) have high mortality. Cardiogenic shock can also occur in nonhypotensive or normotensive patients (intermediate-risk but is less well characterized.The authors sought to evaluate the prevalence predictors of intermediate-risk PE.Intermediate-risk PE FLASH (FlowTriever All-Comer Registry for Patient Safety Hemodynamics) registry undergoing mechanical thrombectomy FlowTriever System (Inari Medical) were included. The...
Background: There is a lack of randomized controlled trial (RCT) data comparing outcomes different catheter-based interventions for intermediate-risk pulmonary embolism (PE). Methods: PEERLESS prospective, multicenter, RCT that enrolled 550 PE patients with right ventricular dilatation and additional clinical risk factors 1:1 to treatment large-bore mechanical thrombectomy (LBMT) or catheter-directed thrombolysis (CDT). The primary endpoint was hierarchal win ratio (WR) composite the...
Background We provide the first multicenter analysis of patients cared for by eight Pulmonary Embolism Response Teams (PERTs) in United States (US); describing frequency team activation, patient characteristics, pulmonary embolism (PE) severity, treatments delivered, and outcomes. Methods enrolled from National PERT Consortium™ registry with a activation between 18 October 2016 17 2017. Data are presented combined institution. Differences institutions were analyzed using chi‐squared test or...
Catheter-based therapies (CBTs) have been developed as a treatment option in patients with pulmonary embolism (PE). There remains paucity of data to inform decision-making intermediate-risk or high-risk PE. The aim this study was characterize in-hospital and readmission outcomes PE treated vs. without CBT large retrospective registry.
The aim of this study was to evaluate the efficacy regadenoson, in comparison with adenosine, for assessing fractional flow reserve (FFR) intermediate coronary artery stenoses (CAS). Fractional is an established invasive method physiological significance CAS. Regadenoson, a selective A2A receptor agonist, approved hyperemic agent pharmacological stress imaging, but its role measuring FFR unknown. This prospective, single-center enrolled 25 consecutive patients CAS discovered during elective...
Background Acute coronary syndrome (ACS) complicated by shock is associated with high mortality despite the use of percutaneous support devices. Extracorporeal membrane oxygenation (ECMO) offers cardiopulmonary but its safety and efficacy in ACS setting still under investigation. Methods We reviewed clinical characteristics course 18 consecutive patients who received femoral veno‐arterial ECMO cardiac catheterization lab for severe due to at our center between 2007 2013. Results The average...
Abstract Objective Examine FlowTriever thrombectomy feasibility in high‐risk PE patients. Background The system (Inari Medical, Irvine, CA) can reduce right ventricle (RV) strain acute submassive pulmonary embolism (PE) This technology has not been studied higher risk Methods multicenter retrospective analysis included patients treated with between 2017 and 2019 if they met at least one of the following: vasopressor dependence, induced respiratory failure, or decreased cardiac index (CI)...
Catheter-directed thrombolysis (CDT) and systemic (ST) are used to treat intermediate/high-risk pulmonary embolism (PE) in the absence of comparative safety effectiveness data. We utilized a large administrative database perform analysis catheter-directed versus thrombolysis. From Optum ® Clinformatics Data Mart private-payer insurance claims database, we identified 100,744 patients hospitalized with PE between 2004 2014. extracted demographic characteristics, high-risk features, components...
Mechanical thrombectomy provides rapid hemodynamic improvements after acute pulmonary embolism (PE), but long-term benefits are uncertain.
Abstract Objectives Compare in‐hospital outcomes of patients treated with either mechanical thrombectomy (MT) or catheter directed lysis (CDL) in treatment acute pulmonary embolism (PE). Methods This is a multicenter, retrospective cohort study undergoing MT CDL for PE between 2014 and 2021. The primary outcome was the composite death, significant bleed, vascular complication, need support post‐procedure. Secondary included individual components addition to blood transfusions, invasive...
To investigate the invasive hemodynamics in patients with intermediate-risk pulmonary embolism (PE) and change that occurs catheter-directed thrombolysis (CDT).Intermediate-risk PE is associated right ventricular strain worse outcomes yet have not been well described.Ninety-two consecutive referred for CDT at two tertiary medical centers Pulmonary Embolism Response Teams were included this prospective cohort study. Hemodynamics baseline after therapy was measured. Patients cardiac index (CI)...
Abstract Background Patients requiring lung transplantation ( LT x) may also have coronary artery disease CAD ). The peri‐operative management and long‐term outcomes of these patients are not well established. Methods referred for x from 2008 to 2014 were included in this study. was defined by angiography as no (stenosis <20%), moderate (20%‐69%), significant ≥70%). Revascularization per recommendations local heart team. Postoperative cardiovascular survival reported. Results A total 1493...