A5005122715- Cerebrovascular and Carotid Artery Diseases
- Cardiovascular Health and Disease Prevention
- Cardiac Imaging and Diagnostics
- Acute Ischemic Stroke Management
- Coronary Interventions and Diagnostics
- Advanced MRI Techniques and Applications
- Cardiovascular Disease and Adiposity
- Intracranial Aneurysms: Treatment and Complications
- Cancer, Hypoxia, and Metabolism
- Asian Culture and Media Studies
- Elasticity and Material Modeling
- Japanese History and Culture
- Peroxisome Proliferator-Activated Receptors
- Moyamoya disease diagnosis and treatment
- Medical Image Segmentation Techniques
- Traumatic Brain Injury and Neurovascular Disturbances
- Multiple Sclerosis Research Studies
- Neurological and metabolic disorders
- Acute Kidney Injury Research
- Peripheral Neuropathies and Disorders
- Oropharyngeal Anatomy and Pathologies
- Atrial Fibrillation Management and Outcomes
- Neurological Complications and Syndromes
- Biochemical Acid Research Studies
- Medical Imaging Techniques and Applications
University of Pittsburgh
2023-2024
Lake Erie College of Osteopathic Medicine
2023
University of Oxford
2018-2023
Children's Hospital of Pittsburgh
2023
Oxford Health NHS Foundation Trust
2023
University of Pittsburgh Medical Center
2023
Resonance Research (United States)
2022
University of Cambridge
2008-2021
Oxford University Hospitals NHS Trust
2015-2020
John Radcliffe Hospital
2015-2019
The aim of this study was to evaluate the mechanical triggers that may cause plaque rupture. Wall shear stress (WSS) and pressure gradient are direct forces acting on in a stenotic artery. Their influence stability is thought be controversial. This used physiologically realistic, pulsatile flow, two-dimensional, cine phase-contrast MRI sequence patient with 70% carotid stenosis. Instead considering full patient-specific bifurcation derived from MRI, only region has been modelled by means...
Significance Statement In this study, we demonstrate that a common, low-cost compound known as octanedioic acid (DC 8 ) can protect mice from kidney damage typically caused by ischemia-reperfusion injury or the chemotherapy drug cisplatin. This seems to enhance peroxisomal activity, which is responsible for breaking down fats, without adversely affecting mitochondrial function. DC not only affordable and easy administer but also effective. These encouraging findings suggest could potentially...
Lipostabil, advertised as an injectable product for eliminating fat, has been available 3 decades in Europe, South America, and Africa the treatment of numerous medical conditions. The author outlines what is known about aesthetic applications Lipostabil explores important questions that remain unanswered.
<h3>Objectives</h3> There is considerable evidence that patients with carotid artery stenosis treated immediately after the ischaemic cerebrovascular event have a better clinical outcome than those who delayed treatment. Biomechanical assessment of plaques using high-resolution MRI can help examine relationship between timing plaque symptomology and maximum simulated stress concentration. <h3>Methods</h3> Fifty underwent multisequence in vivo their arteries. Patients acute symptoms (n=25)...
Carotid atherosclerosis may lead to devastating clinical outcomes such as stroke. Data on the value of local factors in predicting progression carotid are limited. Our aim was investigate association endothelial shear stress (ESS) and low-density lipoprotein (LDL) accumulation with natural history atherosclerotic disease using a series 3 time points human magnetic resonance data. Three-dimensional lumen/wall reconstruction performed 12 carotids, blood flow LDL mass transport modeling were...
Up to 25% of embolic strokes occur in individuals without atrial fibrillation (AF) or other identifiable mechanisms. To assess whether left (LA) blood flow characteristics are associated with brain infarcts, independently AF. The authors recruited 134 patients: 44 a history ischemic stroke and 90 no but CHA2DS2VASc (congestive heart failure, hypertension, age ≥75 [doubled], diabetes, vascular disease, 65 74, sex category [female]) score ≥1. Cardiac magnetic resonance (CMR) evaluated cardiac...
Succinylation is an understudied posttranslational modification that has been shown to increase peroxisomal activity. Furthermore, increased activity reduce oxidative stress and protect proximal tubules after acute kidney injury. Analysis of mass spectrometry succinylomic proteomic data reveals a novel role for Parkinson’s related Park7 in mediating Nrf2 antioxidant response This protection pathway provides new insights injury prevention development therapeutics.
To examine the cardioprotective efficacy of allopurinol in patients undergoing elective coronary artery surgery.Prospective randomised trial.London teaching hospital.Twenty with at least moderately good left ventricular function surgery and requiring two bypass grafts.Patients were to receive (1200 mg divided doses) or act as controls.The primary determinant myocardial protection was serial measurement (preoperatively subsequently one, six, 24, 72 hours after end cardiopulmonary bypass)...
Background: Biomechanical stresses play an important role in determining plaque stability. Quantification of these simulated can be potentially used to assess vulnerability and differentiate different patient groups. Methods Results: 54 asymptomatic 45 acutely symptomatic patients underwent vivo multicontrast magnetic resonance imaging (MRI) the carotid arteries. Plaque geometry for nite element analysis was derived from MRI at sites maximum minimum burden. In total, 198 slices were...
Carotid plaque rupture, characterized by ruptured fibrous cap (FC), is associated with subsequent cerebrovascular events. However, FC may heal following stroke and convey decreased risk of future This study aims to characterize the healing process assessing lumen conditions, quantified curvature roughness, using in vivo carotid cardiovascular magnetic resonance (CMR).
Low profile braided stents have facilitated the endovascular treatment of broad-based intracranial aneurysms.Between 2013 and June 2018, we attempted 104 Leo baby stent placements in 101 patients. Locations were anterior communicating artery (AcomA) (37 aneurysms, 35.6%), middle cerebral (MCA) bifurcation (29 27.9%) basilar (23aneurysms, 22.1%). Mean neck size was 4.9 mm (2.2-8.2). 60 aneurysms incidental, 31 37 recurrent had ruptured before.Stent deployment successful 89.4% cases. Common...