Brendon Frankel

ORCID: 0009-0001-0946-9820
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About
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Research Areas
  • Biochemical Acid Research Studies
  • Advanced Glycation End Products research
  • Cancer, Hypoxia, and Metabolism

University of Pittsburgh
2024

Succinylation is an understudied posttranslational modification that has been shown to increase peroxisomal activity. Furthermore, increased activity reduce oxidative stress and protect proximal tubules after acute kidney injury. Analysis of mass spectrometry succinylomic proteomic data reveals a novel role for Parkinson’s related Park7 in mediating Nrf2 antioxidant response This protection pathway provides new insights injury prevention development therapeutics.

10.1152/ajprenal.00062.2024 article EN AJP Renal Physiology 2024-05-02
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