A5066348250- Circular RNAs in diseases
- MicroRNA in disease regulation
- Spondyloarthritis Studies and Treatments
- Extracellular vesicles in disease
- Bone and Joint Diseases
- Diabetes Treatment and Management
- Anodic Oxide Films and Nanostructures
- Autoimmune and Inflammatory Disorders Research
- Cardiovascular Disease and Adiposity
- Cancer, Hypoxia, and Metabolism
- Cancer-related molecular mechanisms research
- Cardiovascular Function and Risk Factors
- Heart rate and cardiovascular health
- Corrosion Behavior and Inhibition
- RNA Interference and Gene Delivery
- Cancer-related gene regulation
- Dermatology and Skin Diseases
- RNA regulation and disease
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Epigenetics and DNA Methylation
- Atrial Fibrillation Management and Outcomes
- Histone Deacetylase Inhibitors Research
- Conducting polymers and applications
- Lymphoma Diagnosis and Treatment
- Heart Failure Treatment and Management
University of Oxford
2016-2023
John Radcliffe Hospital
2016-2021
Istituti di Ricovero e Cura a Carattere Scientifico
1991-2021
Humanitas University
2021
IRCCS Humanitas Research Hospital
2020-2021
Centro Cardiologico Monzino
2010-2020
University of Milan
2020
Goethe University Frankfurt
2014
Hospital Universitario Santa Cristina
2011
AimsCirculating microRNAs (miRNAs) may represent a novel class of biomarkers; therefore, we examined whether acute myocardial infarction (MI) modulates miRNAs plasma levels in humans and mice.
We examined circulating miRNA expression profiles in plasma of patients with coronary artery disease (CAD) vs. matched controls, the aim identifying novel discriminating biomarkers Stable (SA) and Unstable (UA) angina.An exploratory analysis plasmatic profile 367 miRNAs was conducted a group SA UA control donors, using TaqMan microRNA Arrays. Screening confirmation were performed by qRT-PCR: all found dysregulated troponin-negative (n=19) (n=34) subjects (n=20), for sex, age, cardiovascular...
Abstract Aims Recent clinical trials indicate that sodium-glucose cotransporter 2 (SGLT2) inhibitors improve cardiovascular outcomes in heart failure patients, but the underlying mechanisms remain unknown. We explored direct effects of canagliflozin, an SGLT2 inhibitor with mild SGLT1 inhibitory effects, on myocardial redox signalling humans. Methods and results Study 1 included 364 patients undergoing cardiac surgery. Right atrial appendage biopsies were harvested to quantify superoxide...
Atrial fibrillation (AF) is a growing public health burden, and its treatment remains challenge. AF leads to electrical remodeling of the atria, which in turn promotes maintenance resistance treatment. Although has long been therapeutic target AF, causes remain poorly understood. We show that atrial-specific up-regulation microRNA-31 (miR-31) goat human depletes neuronal nitric oxide synthase (nNOS) by accelerating mRNA decay alters nNOS subcellular localization repressing dystrophin...
This study investigates the diabetes-associated alterations present in cardiac mesenchymal cells (CMSC) obtained from normoglycemic (ND-CMSC) and type 2 diabetic patients (D-CMSC), identifying histone acetylase (HAT) activator pentadecylidenemalonate 1b (SPV106) as a potential pharmacological intervention to restore cellular function. D-CMSC were characterized by reduced proliferation rate, diminished phosphorylation at H3 serine 10 (H3S10P), decreased differentiation potential, premature...
Visceral obesity is directly linked to increased cardiovascular risk, including heart failure. This study explored the ability of human epicardial adipose tissue (EAT)-derived microRNAs (miRNAs) regulate myocardial redox state and clinical outcomes. screened for miRNAs expressed released from EAT tested correlations with in adjacent myocardium paired EAT/atrial biopsy specimens patients undergoing cardiac surgery. Three were then causality an vitro model cardiomyocytes. At a level,...
(1)Background: Chronic heart failure (CHF) contributes to the overall burden of cardiovascular disease. Early identification at-risk individuals may facilitate targeting precision therapies. Plasma microRNAs are promising circulating biomarkers for their implications with cardiac pathologies. In this pilot study, we investigate possible exploitability micro-RNAs (miRNAs) track chronic occurrence, and progression from NYHA class I IV. (2)Methods: We screened 367 using TaqMan microRNA Arrays...
Fourteen scans employing the adrenergic blocking agent [131I]MIBG were performed on 10 children with neuroblastoma (NB) or ganglioneuroblastoma (GNB). The negative in 5 cases, and 1 further case produced doubtful results both MIBG CT scan tests. In 4 very positive obtained clear vision of primary tumor its metastases. case, which demonstrated partial differentiation outer part mass toward GNB, a differentiated specimen did not reveal significant uptake tracer. Half-lives tracer as measured...
Abstract Background Recent clinical trials have demonstrated a role for sodium glucose cotransporter 2 (SGLT2) inhibitors in improving cardiovascular outcomes heart failure patients, but the underlying mechanisms remain unknown. We investigated direct effects of canagliflozin, non-selective SGLT1/SGLT2 inhibitor on myocardial redox signalling humans. Methods Study 1 included 364 patients undergoing cardiac surgery. Human right atrial appendage biopsies, obtained during surgery, were used to...
Purpose: Circulating microRNAs (miRNAs) have recently been identified and proposed as novel biomarkers of several diseases. Here we examined miRNAs expression profile heart failure (HF) patients, NYHA class I-IV, in comparison to matched controls. Methods: We analyzed the 365 plasma samples from healthy donors (n= 5) I-IV HF patients 5/group). MiRNAs was evaluated using TaqMan microRNA Arrays followed by a validation step. Results were normalized miR-532-5p an internal experimentally...
Abstract Background Visceral obesity is directly linked to increased cardiovascular risk, including heart failure. Purpose We explored the ability of human epicardial adipose tissue (EAT)-derived microRNAs (miRNAs) regulate myocardial redox state and clinical outcomes. Methods The 5 study arms included 466 patients undergoing cardiac surgery perform: 1) discovery phase in which we screened for 351 miRNAs expressed released from EAT; 2) correlation analyses between EAT expression their...
Heart failure -Diagnostic assessment 829 those without any of them (59% vs 33% 13%, respectively, p<0.0001).Hazard ratio (HR) for cardiac death abnormal 6MWT and greater ADMIRE-HF risk score (7.3 [95% CI 2.6 to 20.7]) was 2.5-fold HR either or (2.8 1.3 5.9]).Figure 1 Conclusion: provides additional prognostic information the in CHF patients.