A5074506715- Transplantation: Methods and Outcomes
- Mechanical Circulatory Support Devices
- Cardiac Structural Anomalies and Repair
- Organ Transplantation Techniques and Outcomes
- Renal Transplantation Outcomes and Treatments
- Heart Failure Treatment and Management
- Cardiac Valve Diseases and Treatments
- Cardiovascular Function and Risk Factors
- Cardiac Arrest and Resuscitation
- Congenital Heart Disease Studies
- Viral Infections and Immunology Research
- Pulmonary Hypertension Research and Treatments
- Cardiovascular Issues in Pregnancy
- Fuel Cells and Related Materials
- Infective Endocarditis Diagnosis and Management
- Pregnancy and Medication Impact
- Cardiac pacing and defibrillation studies
- Atrial Fibrillation Management and Outcomes
- Cardiac Ischemia and Reperfusion
- Erythropoietin and Anemia Treatment
- COVID-19 Clinical Research Studies
- Aortic Disease and Treatment Approaches
- Cardiovascular Disease and Adiposity
- Organ and Tissue Transplantation Research
- Iron Metabolism and Disorders
Papworth Hospital
2018-2025
Papworth Hospital NHS Foundation Trust
2018-2024
University of Ulster
2018-2024
Royal Victoria Hospital
2018-2024
International Society for Heart and Lung Transplantation
2024
IFC Research (United Kingdom)
2024
University Health Network
2016-2020
University of Toronto
2020
Toronto General Hospital
2016-2017
Freeman Hospital
2014-2016
<h3>Objective</h3> To determine whether or not radiofrequency ablation (RFA) for persistent atrial fibrillation in patients with advanced heart failure leads to improvements cardiac function. <h3>Setting</h3> Patients were recruited from outpatient clinics Scotland. <h3>Design and intervention</h3> severe left ventricular dysfunction randomised RFA (rhythm control) continued medical treatment (rate control). followed up a minimum of 6 months. <h3>Main outcome measure</h3> Change ejection...
In an effort to address the increasing demand for heart transplantation within United Kingdom (UK), we established a clinical program of from donation after circulatory-determined death (DCD) donors in 2015. After 5 years, report early outcomes and impact program.This is single-center, retrospective, matched, observational cohort study comparing hearts transplanted DCD March 1, 2015 February 29, 2020 with those matched brain (DBD) at Royal Papworth Hospital (RPH) (Cambridge, UK). were either...
BackgroundHeart transplantation is an effective treatment offering the best recovery in both quality and quantity of life those affected by refractory, severe heart failure. However, limited donor organ availability. The reintroduction donation after circulatory determination death (DCD) 2014 offered uplift transplant activity 30%. Thoraco-abdominal normothermic regional perfusion (taNRP) enables in-situ reperfusion DCD heart. objective this paper to assess clinical outcomes hearts recovered...
Diabetes and heart failure commonly coexist, prior studies have suggested better outcomes with metformin than other antidiabetic agents. We designed this study to determine whether association reflects a beneficial effect of or harmful agents.We performed case-control nested within the U.K. General Practice Research Database cohort in which diagnoses were assigned by each patient's primary care physician. Case subjects patients 35 years older, newly diagnosed both diabetes after January...
<b>Objective</b> To determine the frequency of survival, stroke, atrial fibrillation, structural valve deterioration, and length hospital stay after surgical replacement an aortic (SAVR) with a bioprosthetic in patients severe symptomatic stenosis. <b>Design</b> Systematic review meta-analysis observational studies. <b>Data sources</b> Medline, Embase, PubMed (non-Medline records only), Cochrane Database Systematic Reviews, CENTRAL from 2002 to June 2016. <b>Study...
There is uncertainty about the definition of iron deficiency (ID) and association between ID prognosis in patients with advanced heart failure. We evaluated three definitions referred for transplantation.Consecutive assessed transplantation at a single UK centre January 2010 May 2022 were included. was defined as (1) serum ferritin concentration <100 ng/ml, or 100-299 ng/ml transferrin saturation <20% (guideline definition), (2) ≤13 μmol/L, (3) <20%. The primary outcome measure composite...
An implantable left ventricular assist device (LVAD) is indicated as a bridge to transplantation or recovery in the United Kingdom (UK). The mechanism of action LVAD results unique state haemodynamic stability with diminished arterial pulsatility. clinical assessment an recipient can be challenging because non-invasive blood pressure, pulse and oxygen saturation measurements may hard obtain. As result this unusual situation complex interplay between native circulation, resuscitation...
Diabetes and heart failure frequently coexist. Our aim was to assess the association between diabetes short- long-term outcomes in all patients admitted hospital for first time with Scotland 1986 2003.A total of 116 556 were studied, whom 13% (n=15 161) had a diagnosis diabetes. At 30 days, associated lower case fatality. By 1 year, better outcome reversed, significant independent predictor higher The longer term risk death greatest younger patients. In aged 65 years or younger, hazard ratio...
Successful pregnancy following cardiac transplantation has been described, although outcome data from individual centers are relatively sparse. We investigated maternal and fetal outcomes including change in left ventricular (LV) function calcineurin inhibitor (CNI) dose women who became pregnant our institution.We identified every female patient <49 years at the time of transplant survived >3 months post-surgery, between 1985 2014. Those conceived had a review their medical records charts....
Abstract Aims To assess pericoronary adipose tissue (PCAT) density on coronary computed tomography angiography (CCTA) as a marker of inflammatory disease activity in allograft vasculopathy (CAV). Methods and results PCAT density, lesion volumes, total vessel volume-to-myocardial mass ratio (V/M) were retrospectively measured 126 CCTAs from 94 heart transplant patients [mean age 49 (SD 14.5) years, 40% female] who underwent imaging between 2010 2021; age- sex-matched controls; with...
Vasoplegia has been associated with inferior outcomes following heart transplantation (HTx). This observational study was designed to investigate in recipients vasoplegia left ventricular assist device (LVAD) explant HTx.Patients undergoing LVAD followed by HTx from 01/2013-12/2018 at our centre were included. defined as the requirement for high dose vasopressor [noradrenaline (>0.5 μg/kg/min) and vasopressin (>1 U/h)] over first 24 hours HTx. Demographic outcome data retrieved transplant...
Third-generation ventricular assist devices (VADs) are associated with improved outcomes, though in recent clinical trials bridge-to-transplant (BTT) rates ∼30% at 6 months, so that transplantation can be used as a 'bail out' for serious complications. In the UK, there was significant reduction heart over last decade, from VADs is much less frequent. The objective of this study to determine outcomes and their predictors situation low BTT rates, patients were exposed long-term support,...
Hyperinflammation and cytokine release has been associated with severe Covid-19. Hemadsorption cartridges may have a potential role in treatment of storm the development Covid-19.We retrospectively examined case records patients Covid-19 receiving adjunctive hemadsorption (HA) our ICU. We analyzed inflammatory biomarkers pre- post- HA.Fifteen received HA during study period. All were intubated, ventilated required renal replacement therapy. 11/15 supported on ECMO. Mean ferritin 2652 (±3286)...