A5037821258- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Dental Erosion and Treatment
- Dental Implant Techniques and Outcomes
- Dental Research and COVID-19
- Delphi Technique in Research
- COVID-19 Clinical Research Studies
- Oral microbiology and periodontitis research
- Dental Radiography and Imaging
- Long-Term Effects of COVID-19
- Osteoarthritis Treatment and Mechanisms
- Periodontal Regeneration and Treatments
- Dental Anxiety and Anesthesia Techniques
- Childhood Cancer Survivors' Quality of Life
- Dental materials and restorations
- Dental Health and Care Utilization
- Cancer survivorship and care
- Melanoma and MAPK Pathways
- CAR-T cell therapy research
- Retinal Diseases and Treatments
- Glaucoma and retinal disorders
- SARS-CoV-2 and COVID-19 Research
- Cancer Immunotherapy and Biomarkers
- Knee injuries and reconstruction techniques
- COVID-19 and Mental Health
University of Toronto
2020-2024
McMaster University
2015-2023
Impact
2017-2023
Canada Research Chairs
2023
University of New Brunswick
2023
Clinical Orthopaedics and Related Research
2019
Cochrane
2019
St. Joseph’s Healthcare Hamilton
2017
Vancouver Coastal Health
2015
Vancouver Coastal Health Research Institute
2015
To develop an instrument to evaluate the credibility of anchor based minimal important differences (MIDs) for outcome measures reported by patients, and assess reliability instrument.Instrument development study.Initial criteria were developed evaluating MIDs on a literature review (Medline, Embase, CINAHL, PsycInfo databases) experience authors in methodology estimation MIDs. Iterative discussions team pilot testing with experts potential users facilitated final instrument.With newly...
"If anything kills over 10 million people in the next few decades, it's most likely to be a highly infectious virus, rather than war. Not missiles, but microbes. Now, part of this reason is that we've invested huge amount nuclear deterrents, actually very little system stop an epidemic. We're not ready for epidemic." —Bill Gates, TEDx, Vancouver, British Columbia, Canada, 2015 The outbreak novel coronavirus, referred as severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) or...
<b>Objective</b> To determine the frequency of survival, stroke, atrial fibrillation, structural valve deterioration, and length hospital stay after surgical replacement an aortic (SAVR) with a bioprosthetic in patients severe symptomatic stenosis. <b>Design</b> Systematic review meta-analysis observational studies. <b>Data sources</b> Medline, Embase, PubMed (non-Medline records only), Cochrane Database Systematic Reviews, CENTRAL from 2002 to June 2016. <b>Study...
<b>Objective</b> To examine the effect of transcatheter aortic valve implantation (TAVI) versus surgical replacement an (SAVR) in patients with severe stenosis at low and intermediate risk perioperative death. <b>Design</b> Systematic review meta-analysis <b>Data sources</b> Medline, Embase, Cochrane CENTRAL. <b>Study selection</b> Randomized trials TAVI compared SAVR a mean death <8%. <b>Review methods</b> Two reviewers independently extracted data assessed bias...
Providing optimal critical care in developing countries is limited by lack of recognition illness and essential resources. The Modified Early Warning Score (MEWS), based on physiological parameters, validated adult medical surgical patients as a predictor mortality. objective this study performed Uganda was to determine the prevalence wards defined MEWS, evaluate MEWS death, describe additional risk factors for mortality.We conducted prospective observational at Mulago National Referral...
Researchers have proposed that the minimal important difference (MID), smallest change or patients perceive as important, could aid interpretation of patient reported outcomes measure (PROM) scores. When multiple MIDs for a given PROM differ substantially, selection an optimal MID to prove challenging. This article describes systematic, step-by-step approach developed resolve this problem. An MID, at least, should be methodologically sound and should, far possible, match intended application...
Sarcolipin (SLN) and phospholamban (PLN) inhibit the activity of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs) by reducing their apparent affinity for Ca2+. A ternary complex between SLN, PLN, SERCAs results in super-inhibition SERCA activity. Analysis skeletal muscle homogenate has limited our current understanding whether SLN PLN regulate SERCA1a, SERCA2a, or both are co-expressed fibers. Biopsies from human vastus lateralis were analyzed through single fiber Western blotting...
Objective To compare the effects of interleukin 6 receptor blockers, tocilizumab and sarilumab, with or without corticosteroids, on mortality in patients covid-19. Design Systematic review network meta-analysis. Data sources World Health Organization covid-19 database, a comprehensive multilingual source global literature, two prospective meta-analyses (up to 9 June 2021). Review methods Trials which people suspected, probable, confirmed were randomised blockers (with corticosteroids),...