A5075098080- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Ethics in Clinical Research
- Statistical Methods in Clinical Trials
- Musculoskeletal pain and rehabilitation
- Delphi Technique in Research
- Workplace Health and Well-being
- COVID-19 Clinical Research Studies
- Health and Medical Research Impacts
- Healthcare cost, quality, practices
- Pain Management and Opioid Use
- Ultrasound and Hyperthermia Applications
- Lymphoma Diagnosis and Treatment
- Advanced Causal Inference Techniques
- Long-Term Effects of COVID-19
- Clinical practice guidelines implementation
- CNS Lymphoma Diagnosis and Treatment
- Health Policy Implementation Science
- SARS-CoV-2 and COVID-19 Research
- Pharmaceutical industry and healthcare
- Bone fractures and treatments
- Ultrasound in Clinical Applications
- Glioma Diagnosis and Treatment
- Childhood Cancer Survivors' Quality of Life
- Occupational Health and Safety Research
University Hospital of Basel
2016-2025
University of Basel
2015-2025
University College Cork
2024-2025
University of Pecs
2023-2025
McMaster University
2016-2022
Impact
2017-2022
Careers Europe
2021
University of Michigan–Ann Arbor
2020
Sidney Kimmel Comprehensive Cancer Center
2020
Johns Hopkins University
2020
<h3>BACKGROUND:</h3> Most randomized controlled trials (RCTs) and meta-analyses of RCTs examine effect modification (also called a subgroup or interaction), in which the an intervention varies by another variable (e.g., age disease severity). Assessing credibility apparent presents challenges; therefore, we developed Instrument for assessing Credibility Effect Modification Analyses (ICEMAN). <h3>METHODS:</h3> To develop ICEMAN, established detailed concept; identified candidate...
<h3>Importance</h3> The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. epidemiology discontinued RCTs, however, remains unclear. <h3>Objectives</h3> To determine the prevalence, characteristics, publication history RCTs to investigate factors associated with RCT due poor recruitment nonpublication. <h3>Design Setting</h3> Retrospective cohort based on archived protocols approved by 6 ethics committees in Switzerland,...
To develop an instrument to evaluate the credibility of anchor based minimal important differences (MIDs) for outcome measures reported by patients, and assess reliability instrument.Instrument development study.Initial criteria were developed evaluating MIDs on a literature review (Medline, Embase, CINAHL, PsycInfo databases) experience authors in methodology estimation MIDs. Iterative discussions team pilot testing with experts potential users facilitated final instrument.With newly...
ObjectivesTo update previous Grading of Recommendations Assessment, Development and Evaluation (GRADE) guidance by addressing inconsistencies interpreting subgroup analyses.Study Design SettingUsing an iterative process, we consulted with members the GRADE working group through multiple rounds written feedback discussions at meetings.ResultsThe complements clarification in two areas: (1) assessing inconsistency (2) credibility possible effect modifiers that might explain inconsistency....
To investigate the planning of subgroup analyses in protocols randomised controlled trials and agreement with corresponding full journal publications.Cohort trial subsequent publications.Six research ethics committees Switzerland, Germany, Canada.894 involving patients approved by participating between 2000 2003 515 publications.Of 894 trials, 252 (28.2%) included one or more planned analyses. Of those, 17 (6.7%) provided a clear hypothesis for at least analysis, 10 (4.0%) anticipated...
<ns4:p><ns4:bold>Background</ns4:bold>: Never before have clinical trials drawn as much public attention those testing interventions for COVID-19. We aimed to describe the worldwide COVID-19 research response and its evolution over first 100 days of pandemic.</ns4:p><ns4:p><ns4:bold>Methods:</ns4:bold>Descriptive analysis planned, ongoing or completed by April 9, 2020 any intervention treat prevent COVID-19, systematically identified in trial registries, preprint servers, literature...
Introduction Methodological studies (ie, that evaluate the design, conduct, analysis or reporting of other in health research) address various facets research including, for instance, data collection techniques, differences approaches to analyses, quality, adherence guidelines publication bias. As a result, methodological can help identify knowledge gaps methodology and strategies improvement practices. Differences study names lack guidance contribute comparability across difficulties...
Abstract Background Poor participant recruitment is the most frequent reason for premature discontinuation of randomized clinical trials (RCTs), particularly if they are investigator-initiated. The aims this qualitative study were to investigate (1) views trial stakeholders from three different countries regarding reasons failure in RCTs and (2) how these compare contrast with causes identified a previous systematic review RCT publications. Methods From August 2015 November 2016, we...
Background We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2000 and 2003 were discontinued prematurely, 44% remained unpublished at a median 12 years follow-up. aimed to assess decade later (1) whether rates completion publication have increased; (2) the extent which nonpublished RCTs can be identified in trial registries; (3) association reporting quality protocols premature discontinuation or nonpublication RCTs. Methods findings included 326 RCT...
BackgroundThe goal of this systematic review was to examine the efficacy and safety proton-pump inhibitors for stress ulcer prophylaxis in critically ill patients.MethodsWe included randomized trials comparing versus placebo or no adults, performed meta-analyses, assessed certainty evidence using Grading Recommendations, Assessment, Development, Evaluations approach. To explore effect on mortality based disease severity, a subgroup analysis conducted combining within-trial data from two...