Heike Raatz
A5082702320- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Ethics in Clinical Research
- Clinical practice guidelines implementation
- Bariatric Surgery and Outcomes
- Cardiac Imaging and Diagnostics
- Ocular Diseases and Behçet’s Syndrome
- Vasculitis and related conditions
- Radiomics and Machine Learning in Medical Imaging
- Healthcare Systems and Technology
- Radiation Dose and Imaging
- Endometrial and Cervical Cancer Treatments
- Medical Imaging Techniques and Applications
- Patient Satisfaction in Healthcare
- Statistical Methods in Clinical Trials
- Advanced X-ray and CT Imaging
- Antibiotic Use and Resistance
- Delphi Technique in Research
- Esophageal Cancer Research and Treatment
- Ultrasound and Hyperthermia Applications
- Healthcare cost, quality, practices
- Retinal Diseases and Treatments
- Iron Metabolism and Disorders
- Cholinesterase and Neurodegenerative Diseases
- Advanced Causal Inference Techniques
University Hospital of Basel
2011-2023
University of Basel
2016-2022
University of Freiburg
2022
Kleijnen Systematic Reviews (United Kingdom)
2019-2020
University of Zurich
2017
Swiss Academy of Medical Sciences
2015
<h3>Importance</h3> The discontinuation of randomized clinical trials (RCTs) raises ethical concerns and often wastes scarce research resources. epidemiology discontinued RCTs, however, remains unclear. <h3>Objectives</h3> To determine the prevalence, characteristics, publication history RCTs to investigate factors associated with RCT due poor recruitment nonpublication. <h3>Design Setting</h3> Retrospective cohort based on archived protocols approved by 6 ethics committees in Switzerland,...
Life expectancy has dramatically increased in industrialized nations over the last 200 hundred years. The aging of populations carries to clinical research and leads an increasing representation elderly multimorbid individuals study populations. Clinical these is complicated by fact that are likely experience several potential disease endpoints prevent some disease‐specific endpoint interest from occurrence. Large developments competing risks methodology have been achieved decades, but we...
To investigate the planning of subgroup analyses in protocols randomised controlled trials and agreement with corresponding full journal publications.Cohort trial subsequent publications.Six research ethics committees Switzerland, Germany, Canada.894 involving patients approved by participating between 2000 2003 515 publications.Of 894 trials, 252 (28.2%) included one or more planned analyses. Of those, 17 (6.7%) provided a clear hypothesis for at least analysis, 10 (4.0%) anticipated...
Feedback interventions using routinely collected health data might reduce antibiotic use nationwide without requiring the substantial resources and structural efforts of other stewardship programs.To determine if quarterly prescription feedback over 2 years reduces when implemented in a complex care system.Pragmatic randomized trial claims on 2900 primary physicians with highest rates Switzerland.Physicians were to updated personalized (n = 1450) or usual 1450). was provided both by mail...
To investigate the prevalence of discontinuation and nonpublication surgical versus medical randomized controlled trials (RCTs) to explore risk factors for RCTs.Trial has significant scientific, ethical, economic implications. date, RCTs is unknown.All RCT protocols approved between 2000 2003 by 6 ethics committees in Canada, Germany, Switzerland were screened. Baseline characteristics collected and, if published, full reports retrieved. Risk early slow recruitment explored using...
Abstract Summary The first German interdisciplinary S3-guideline on the diagnosis, therapy and follow-up of patients with endometrial cancer was published in April 2018. Funded by Cancer Aid as part an Oncology Guidelines Program, lead coordinators guideline were Society Gynecology Obstetrics (DGGG) Gynecological Working Group (AGO) (DKG). Purpose Using evidence-based, risk-adapted to treat low-risk women avoids unnecessarily radical surgery non-useful adjuvant radiotherapy and/or...
Randomized clinical trials that enroll patients in critical or emergency care (acute care) setting are challenging because of narrow time windows for recruitment and the inability many to provide informed consent. To assess extent challenges lead randomized trial discontinuation, we compared discontinuation acute nonacute trials.Retrospective cohort 894 approved by six institutional review boards Switzerland, Germany, Canada between 2000 2003.Randomized involving an setting.We recorded...
Background Little is known about publication agreements between industry and academic investigators in trial protocols the consistency of these with corresponding statements publications. We aimed to investigate (i) existence types protocols, (ii) completeness reporting subsequent publications, (iii) frequency co-authorship by employees. Methods Findings used a retrospective cohort randomized clinical trials (RCTs) based on archived approved six research ethics committees 13 January 2000 25...
Randomized clinical trials (RCTs) stopped early for benefit often receive great attention and affect practice, but pose interpretational challenges clinicians, researchers, policy makers. Because the decision to stop trial may arise from catching treatment effect at a random high, truncated RCTs (tRCTs) overestimate true effect. The Study Of Trial Policy Interim Truncation (STOPIT-1), which systematically reviewed epidemiology reporting quality of tRCTs, found that such are becoming more...