A5056494354- Health Systems, Economic Evaluations, Quality of Life
- Musculoskeletal pain and rehabilitation
- Meta-analysis and systematic reviews
- Cerebral Palsy and Movement Disorders
- Chronic Disease Management Strategies
- Dupuytren's Contracture and Treatments
- Obesity, Physical Activity, Diet
- Statistical Methods in Clinical Trials
- Primary Care and Health Outcomes
- Balance, Gait, and Falls Prevention
- Health Policy Implementation Science
- Stroke Rehabilitation and Recovery
- Osteoarthritis Treatment and Mechanisms
- Ethics in Clinical Research
- Digital Mental Health Interventions
- Child and Adolescent Health
- Orthopedic Surgery and Rehabilitation
- Medical Coding and Health Information
- Pain Management and Placebo Effect
- Community Health and Development
- Telemedicine and Telehealth Implementation
- Child and Adolescent Psychosocial and Emotional Development
- Genital Health and Disease
- Rheumatoid Arthritis Research and Therapies
- Chemotherapy-related skin toxicity
University of Leeds
2020-2024
Nuffield Orthopaedic Centre
2015-2022
University of Oxford
2015-2022
Loughborough University
2020
Memorial University of Newfoundland
2020
University of Southampton
2017
Abstract The majority of psychological treatment research is dedicated to investigating the effectiveness cognitive behavioural therapy (CBT) across different conditions, population and contexts. We aimed summarise current systematic review evidence evaluate consistency CBT's effect conditions. included reviews CBT randomised controlled trials in any: population, condition, format, context, with any type comparator published English. searched DARE, Cochrane, MEDLINE, EMBASE, PsycINFO,...
Approximately 670,000 people in the UK have dementia. Previous literature suggests that physical exercise could slow dementia symptom progression.To estimate clinical effectiveness and cost-effectiveness of a bespoke programme, addition to usual care, on cognitive impairment (primary outcome), function health-related quality life (HRQoL) with mild moderate (MMD) carer burden HRQoL.Intervention development, systematic review, multicentred, randomised controlled trial (RCT) parallel economic...
Background We previously found that 25% of 1,017 randomized clinical trials (RCTs) approved between 2000 and 2003 were discontinued prematurely, 44% remained unpublished at a median 12 years follow-up. aimed to assess decade later (1) whether rates completion publication have increased; (2) the extent which nonpublished RCTs can be identified in trial registries; (3) association reporting quality protocols premature discontinuation or nonpublication RCTs. Methods findings included 326 RCT...
BackgroundDupuytren's disease is a common fibrotic condition of the hand that causes irreversible flexion contractures fingers, with no approved therapy for early stage disease. Our previous analysis surgically-excised tissue defined tumour necrosis factor (TNF) as potential therapeutic target. Here we assessed efficacy injecting nodules Dupuytren's TNF inhibitor.MethodsPatients were randomised to receive adalimumab on one occasion in dose cohorts 15 mg 0.3 ml, 35 0.7 or 40 0.4 an equivalent...
<h3>Abstract</h3> <h3>Objective</h3> To assess whether randomised controlled trials (RCTs) that were registered less likely to report positive study findings compared with RCTs not and the association varied by funding source. <h3>Design</h3> Cross sectional study. <h3>Study sample</h3> All primary published in December 2012 indexed PubMed November 2013. Trial registration was determined based on of a trial number or identification search registries. Trials separated into prospectively...
Abstract Background Healthcare system data (HSD) are increasingly used in clinical trials, augmenting or replacing traditional methods of collecting outcome data. This study, PRIMORANT, set out to identify, the UK context, issues be considered before decision use HSD for a trial is finalised, methodological question prioritised by trials community. Methods The PRIMORANT study had three phases. First, an initial workshop was held scope faced trialists when considering whether HSDs outcomes....
Many researchers and professional bodies are seeking consensus for core outcomes clinical trials. The Prevention of Falls Network Europe (ProFaNE) developed a common outcome data set fall injury prevention trials 10 years ago. This study assesses the impact these recommendations. A systematic search (up to 16 January 2015) was performed using Web Science, Scopus PubMed articles citing ProFaNE Randomised on in older people were selected further analysis. Data extracted characteristics...
To assess the inter-rater reliability and concurrent validity of Communication Evaluation in Rehabilitation Tool, which aims to externally physiotherapists competency using Self-Determination Theory-based communication strategies practice.Audio recordings initial consultations between 24 patients with chronic low back pain four hospitals Ireland were obtained as part a larger randomised controlled trial. Three raters, all whom had Ph.Ds psychology expertise motivation physical activity,...
Abstract Background Digital technologies, such as wearable devices and smartphone applications (apps), can enable the decentralisation of clinical trials by measuring endpoints in people’s chosen locations rather than traditional settings. allow high-frequency sensitive measurements health outcomes compared to visit-based which provide an episodic snapshot a person’s health. However, there are underexplored challenges this emerging space that require interdisciplinary cross-sector...
Community-based obesity prevention interventions are often commissioned despite the limited evidence base. HENRY (Health, Exercise, Nutrition for Really Young) is a programme delivered to parents of preschool children across UK. Early suggests that it may be effective, but robust evaluation has not been conducted. We initiated systematic by studying feasibility conducting multi-centre definitive trial evaluate its effectiveness and cost-effectiveness prevent obesity. Objectives were assess...
<ns4:p>Dupuytren’s disease is a common fibrotic condition of the hand affecting 4% population and causes fingers to curl irreversibly into palm. It has strong familial tendency, there no approved treatment for early stage disease, patients with established digital contractures are most commonly treated by surgery. This associated prolonged recovery, less invasive techniques have high recurrence rates.The myofibroblasts, cells responsible excessive matrix deposition contraction, aggregated in...
Objective. This study examined whether duration of treatment effect should be considered in a benefit-risk assessment using case osteoarthritis medications. Study Design and Setting. A discrete choice experiment was completed by 300 residents the United Kingdom with hip and/or knee osteoarthritis. In 16 tasks, participants selected their preferred option from 2 Medications were described terms on pain, stiffness, function; effect; risk heart attack stomach ulcer bleeding. The analysis used...